Gene: ARHGAP15

55843
BM046
Rho GTPase activating protein 15
protein-coding
2q22.2-q22.3
Ensembl:ENSG00000075884 MIM:610578 Vega:OTTHUMG00000131845 UniprotKB:Q53QZ3
NC_000002.12
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.656e-1 (AD)  7.176e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11693600chr2:143622973 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10496950chr2:143615404 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs16858596chr2:143132712 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TFEC0.918
TLR10.901
KYNU0.898
MS4A4A0.89
DAPP10.885
SNX200.878
ARL110.878
PTPRC0.865
RGS180.862
HLA-DOA0.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARSF-0.429
WNT7A-0.398
ATP2C2-0.396
KCNIP3-0.388
ASPDH-0.386
WFDC1-0.365
CHRNA4-0.364
PYGM-0.363
CPLX3-0.362
C9orf24-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ARHGAP15 mRNA"20453058
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
D000638AmiodaroneAmiodarone results in increased expression of ARHGAP15 mRNA19774075
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGAP15 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARHGAP15 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of ARHGAP15 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of ARHGAP15 mRNA25979313
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of ARHGAP15 mRNA26272509
D002737ChloropreneChloroprene results in decreased expression of ARHGAP15 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGAP15 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of ARHGAP15 mRNA26577399
D003703DemecolcineDemecolcine results in increased expression of ARHGAP15 mRNA23649840
D002945CisplatinCisplatin results in decreased expression of ARHGAP15 mRNA27594783
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ARHGAP15 mRNA17005392
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ARHGAP15 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGAP15 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ARHGAP15 mRNA23649840
D019833GenisteinGenistein results in increased methylation of ARHGAP15 gene28505145
D005839GentamicinsGentamicins results in increased expression of ARHGAP15 mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGAP15 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARHGAP15 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of ARHGAP15 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARHGAP15 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARHGAP15 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ARHGAP15 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ARHGAP15 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ARHGAP15 mRNA"25554681
D009532NickelNickel results in increased expression of ARHGAP15 mRNA25583101
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ARHGAP15 mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of ARHGAP15 mRNA20813756
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARHGAP15 mRNA26377647
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARHGAP15 mRNA25613284
D013806TheophyllineTheophylline results in increased expression of ARHGAP15 mRNA18951874
C009495titanium dioxidetitanium dioxide results in increased expression of ARHGAP15 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ARHGAP15 mRNA20133372
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ARHGAP15 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGAP15 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ARHGAP15 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ARHGAP15 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of ARHGAP15 mRNA28001369
D014750VincristineVincristine results in increased expression of ARHGAP15 mRNA23649840
D015034Zinc OxideZinc Oxide analog results in increased expression of ARHGAP15 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IDA12650940  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI12650940  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IEA-  
GO:0008360regulation of cell shape-IDA12650940  
GO:0043087regulation of GTPase activity-IBA21873635  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal