Gene: PKN1

5585
DBK|PAK-1|PAK1|PKN|PKN-ALPHA|PRK1|PRKCL1
protein kinase N1
protein-coding
19p13.12
Ensembl:ENSG00000123143 MIM:601032 Vega:OTTHUMG00000039611 UniprotKB:Q16512
NC_000019.10
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.659e-1 (AD)  7.424e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13922488chr19:14545201PKN17.810e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAI20.89
GSTP10.853
EEF1G0.849
RPL13A0.849
FTL0.846
HNRNPUL10.846
CD630.845
RPLP00.844
RPL180.842
RPL140.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.758
OR4F5-0.752
IL1RAPL2-0.25
IL17REL-0.249
PCDHAC1-0.236
CHRM2-0.235
COL19A1-0.235
TYRP1-0.233
TRPC5-0.228
GABRG3-0.228

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PKN1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PKN1 mRNA"21346803
D020106AcrylamideAcrylamide results in increased expression of PKN1 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PKN1 mRNA16483693
D000880AnthraquinonesAnthraquinones analog results in decreased activity of PKN1 protein27473261
D001151ArsenicArsenic affects the methylation of PKN1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PKN1 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKN1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKN1 mRNA22228805
C018021cobaltous chloridecobaltous chloride results in decreased expression of PKN1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of PKN1 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of PKN1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PKN1 mRNA20106945
D002945CisplatinCisplatin results in increased expression of PKN1 mRNA27594783
D004041Dietary FatsDietary Fats results in decreased expression of PKN1 mRNA18042831
D005839GentamicinsGentamicins results in increased expression of PKN1 mRNA22061828
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PKN1 mRNA23086925
D008774MethylphenidateMethylphenidate results in decreased expression of PKN1 mRNA22470460
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PKN1 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PKN1 mRNA22776087
D009151Mustard GasMustard Gas results in increased expression of PKN1 mRNA18955075
D000073878Palm OilPalm Oil results in decreased expression of PKN1 mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of PKN1 mRNA17426115
D011374ProgesteroneProgesterone results in increased expression of PKN1 mRNA23018184
C045950propiconazolepropiconazole results in decreased expression of PKN1 mRNA21278054
D011794QuercetinQuercetin results in decreased expression of PKN1 mRNA21632981
C061133tamibarotenetamibarotene results in increased expression of PKN1 mRNA15498508
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of PKN1 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PKN1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKN1 mRNA21570461
D014212TretinoinTretinoin results in increased expression of PKN1 mRNA15498508
D014635Valproic AcidValproic Acid results in increased methylation of PKN1 gene29154799
D014639VanadiumVanadium results in decreased expression of PKN1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PKN1 gene25560391
C460080Y 32885Y 32885 results in decreased activity of PKN1 protein10998351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IDA18066052  
GO:0004672protein kinase activity-TAS8135837  10792047  
GO:0004674protein serine/threonine kinase activity-EXP18066052  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA20188095  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004697protein kinase C activity-IEA-  
GO:0005080protein kinase C binding-IPI20228790  
GO:0005515protein binding-IPI12761180  16189514  16331689  16611232  20188095  21516116  
25416956  
GO:0005524ATP binding-IEA-  
GO:0017049GTP-Rho binding-IDA9478917  10619026  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IDA12514133  
GO:0030374ligand-dependent nuclear receptor transcription coactivator activity-IMP18066052  
GO:0035402histone kinase activity (H3-T11 specific)-IDA18066052  
GO:0042393histone binding-IDA18066052  
GO:0042826histone deacetylase binding-IDA20188095  
GO:0048365Rac GTPase binding-IDA18006505  
GO:0050681androgen receptor binding-IDA12514133  18066052  
GO ID GO Term Qualifier Evidence PubMed
GO:0001782B cell homeostasis-IEA-  
GO:0001783B cell apoptotic process-IEA-  
GO:0002634regulation of germinal center formation-IEA-  
GO:0002637regulation of immunoglobulin production-IEA-  
GO:0003014renal system process-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA12514133  
GO:0006357regulation of transcription by RNA polymerase II-IMP18066052  
GO:0006468protein phosphorylation-IDA17332740  
GO:0006469negative regulation of protein kinase activity-IEA-  
GO:0006972hyperosmotic response-IEA-  
GO:0007165signal transduction-TAS8135837  
GO:0007257activation of JUN kinase activity-TAS8805275  
GO:0010631epithelial cell migration-IMP21754995  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0030889negative regulation of B cell proliferation-IEA-  
GO:0035407histone H3-T11 phosphorylation-IDA18066052  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0048536spleen development-IEA-  
GO:1903508positive regulation of nucleic acid-templated transcription-IEA-  
GO:2000145regulation of cell motility-IMP21754995  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA12514133  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA12514133  17332740  
GO:0005768endosome-IDA9478917  
GO:0005829cytosol-TAS-  
GO:0030496midbody-IDA17332740  
GO:0032154cleavage furrow-IDA17332740  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5625740RHO GTPases activate PKNsTAS
R-HSA-5625886Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal