Gene: PSENEN

55851
ACNINV2|MDS033|MSTP064|PEN-2|PEN2
presenilin enhancer, gamma-secretase subunit
protein-coding
19q13.12
Ensembl:ENSG00000205155 MIM:607632 Vega:OTTHUMG00000182067 UniprotKB:Q9NZ42
NG_027934.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.430e-1 (AD)  5.391e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM420.913
GNB20.903
RNF1810.902
PGLS0.902
CSTB0.899
KXD10.895
KRTCAP20.894
POLR2J0.894
GSTP10.892
GABARAP0.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.761
OR4F29-0.738
NPR3-0.18
HS6ST3-0.173
PRKG2-0.16
FAM216B-0.158
ADAMTS5-0.153
PP2D1-0.153
TBX4-0.153
IGF1-0.152

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05171E-2012Small Molecule870843-42-8InvestigationalTarget
ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PSENEN mRNA]"19467301
D001280AtrazineAtrazine results in increased expression of PSENEN mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSENEN mRNA22228805
D004958EstradiolEstradiol affects the expression of PSENEN mRNA21632981
D004958EstradiolEstradiol results in decreased expression of PSENEN mRNA23019147
C006780bisphenol Abisphenol A results in increased expression of PSENEN mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of PSENEN mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PSENEN mRNA25181051
D002065BuspironeBuspirone results in increased expression of PSENEN mRNA24136188
C018021cobaltous chloridecobaltous chloride results in decreased expression of PSENEN mRNA19376846
D016572CyclosporineCyclosporine results in increased expression of PSENEN mRNA20106945
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PSENEN mRNA]27941970
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PSENEN mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of PSENEN mRNA19467301
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PSENEN mRNA17606305
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PSENEN mRNA17555576
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of PSENEN mRNA22634610
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PSENEN mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PSENEN mRNA23649840
C012655nimesulidenimesulide results in increased expression of PSENEN mRNA24136188
D010936Plant ExtractsPlant Extracts results in decreased expression of PSENEN mRNA23557933
D011205Povidone[Silver analog co-treated with Povidone] results in decreased expression of PSENEN mRNA25194297
D012834Silver[Silver analog co-treated with Povidone] results in decreased expression of PSENEN mRNA25194297
D013629TamoxifenTamoxifen affects the expression of PSENEN mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PSENEN mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSENEN mRNA21570461|2468072
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PSENEN mRNA25613284
D014050TolueneToluene affects the expression of PSENEN mRNA21827849
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PSENEN gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16641999  18201567  23685131  
GO ID GO Term Qualifier Evidence PubMed
GO:0006509membrane protein ectodomain proteolysis-IDA15274632  
GO:0007219Notch signaling pathway-TAS-  
GO:0007220Notch receptor processing-IBA21873635  
GO:0007220Notch receptor processing-TAS15274632  
GO:0016485protein processing-IDA15274632  
GO:0034205amyloid-beta formation-IMP25043039  26280335  
GO:0035333Notch receptor processing, ligand-dependent-TAS-  
GO:0042982amyloid precursor protein metabolic process-IDA25043039  26280335  
GO:0042987amyloid precursor protein catabolic process-TAS15274632  
GO:0043085positive regulation of catalytic activity-IDA15274632  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA15274632  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005794Golgi apparatus-IDA15274632  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA15274632  
GO:0016021integral component of membrane-IDA25043039  26280335  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0070765gamma-secretase complex-IBA21873635  
GO:0070765gamma-secretase complex-IDA25043039  26280335  
KEGG ID KEGG Term
hsa04330Notch signaling pathway
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1251985Nuclear signaling by ERBB4TAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-157118Signaling by NOTCHIEA
R-HSA-157118Signaling by NOTCHTAS
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-193692Regulated proteolysis of p75NTRTAS
R-HSA-193704p75 NTR receptor-mediated signallingTAS
R-HSA-1980143Signaling by NOTCH1IEA
R-HSA-1980145Signaling by NOTCH2IEA
R-HSA-1980150Signaling by NOTCH4TAS
R-HSA-204998Cell death signalling via NRAGE, NRIF and NADETAS
R-HSA-205043NRIF signals cell death from the nucleusTAS
R-HSA-2122948Activated NOTCH1 Transmits Signal to the NucleusIEA
R-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in CancerTAS
R-HSA-2644603Signaling by NOTCH1 in CancerTAS
R-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsTAS
R-HSA-2682334EPH-Ephrin signalingTAS
R-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in CancerTAS
R-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsTAS
R-HSA-2979096NOTCH2 Activation and Transmission of Signal to the NucleusIEA
R-HSA-3928665EPH-ephrin mediated repulsion of cellsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-73887Death Receptor SignallingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9012852Signaling by NOTCH3TAS
R-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusTAS
R-HSA-9017802Noncanonical activation of NOTCH3TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28892072Neuregulin signaling pathway in smoking behavior. (2017 Aug 22)Gupta RTransl Psychiatry