Gene: BEX1

55859
BEX2|HBEX2|HGR74-h
brain expressed X-linked 1
protein-coding
Xq22.1|Xq22
Ensembl:ENSG00000133169 MIM:300690 Vega:OTTHUMG00000022708 UniprotKB:Q9HBH7
NC_000023.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BEX20.988
HINT10.969
UCHL10.969
PITHD10.969
ATP6V1E10.968
TCEAL20.963
TCEAL50.962
TAGLN30.961
BEX40.958
TERF2IP0.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.704
OR4F29-0.683
MAGEA12-0.387
RUNX3-0.383
CXCR2-0.374
KCNJ15-0.371
REST-0.369
MTRNR2L6-0.365
EVC2-0.364
LATS2-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of BEX1 mRNA"27071940
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"NFE2L2 gene mutant form inhibits the reaction [1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole results in increased expression of BEX1 mRNA]"27071940
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BEX1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BEX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BEX1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BEX1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BEX1 mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of BEX1 mRNA23630614
D001151ArsenicArsenic affects the methylation of BEX1 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BEX1 mRNA19152381|2006483
D001564Benzo(a)pyrenechlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of BEX1 mRNA]19152381
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BEX1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of BEX1 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of BEX1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BEX1 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of BEX1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of BEX1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of BEX1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BEX1 mRNA23288052
D002251Carbon TetrachlorideDiethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of BEX1 mRNA]23288052
D002509CephaloridineCephaloridine results in increased expression of BEX1 mRNA18500788
C007020chlorophyllinchlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of BEX1 mRNA]19152381
D004390ChlorpyrifosChlorpyrifos results in decreased expression of BEX1 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEX1 mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of BEX1 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of BEX1 mRNA15755911
D016572CyclosporineCyclosporine results in decreased expression of BEX1 mRNA25562108|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BEX1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BEX1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of BEX1 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of BEX1 mRNA22023808
C000944dicrotophosdicrotophos results in decreased expression of BEX1 mRNA28302478
D004052DiethylnitrosamineDiethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of BEX1 mRNA]23288052
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BEX1 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BEX1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of BEX1 mRNA19638242
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BEX1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BEX1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BEX1 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEX1 mRNA20938992
D005839GentamicinsGentamicins results in increased expression of BEX1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of BEX1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of BEX1 mRNA21179406
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BEX1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BEX1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of BEX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BEX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BEX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of BEX1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of BEX1 mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of BEX1 mRNA20938992
D009151Mustard GasMustard Gas results in increased expression of BEX1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of BEX1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BEX1 mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of BEX1 mRNA22714537
C558013NSC 689534NSC 689534 results in decreased expression of BEX1 mRNA20971185
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of BEX1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of BEX1 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BEX1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of BEX1 mRNA26272509
D011794QuercetinQuercetin results in decreased expression of BEX1 mRNA21632981
D053260SootSoot affects the expression of BEX1 mRNA26551751
D013629TamoxifenTamoxifen affects the expression of BEX1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of BEX1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BEX1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BEX1 mRNA22298810
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of BEX1 mRNA28943392
D013853ThioacetamideThioacetamide results in increased expression of BEX1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of BEX1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of BEX1 mRNA20133372
D014212TretinoinTretinoin results in decreased expression of BEX1 mRNA21934132
D014415TunicamycinTunicamycin results in decreased expression of BEX1 mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BEX1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BEX1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BEX1 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of BEX1 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of BEX1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001102RNA polymerase II activating transcription factor binding-IPI16314316  
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16314316  
GO:0051091positive regulation of DNA-binding transcription factor activity-IDA16314316  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005667transcription factor complex-IDA16314316  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23362108Epigenetic regulation of the X-linked tumour suppressors BEX1 and LDOC1 in oral squamous cell carcinoma. (2013 Jul)Lee CHJ Pathol