Gene: PKN2

5586
PAK2|PRK2|PRKCL2|PRO2042|Pak-2|STK7
protein kinase N2
protein-coding
1p22.2
Ensembl:ENSG00000065243 MIM:602549 Vega:OTTHUMG00000010074 UniprotKB:Q16513
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.223e-1 (AD)  4.563e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARID20.917
LRRC580.896
LATS10.894
LMAN10.888
NUP1600.886
BTBD70.882
MAP3K20.877
SMAD40.873
STYX0.869
CNOT60.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.506
OR4F29-0.479
CRH-0.294
KCNG2-0.271
NPW-0.261
LCN1-0.248
GSG1-0.237
PRSS56-0.234
LRRC26-0.232
TGM3-0.218

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PKN2 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of PKN2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PKN2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PKN2 mRNA16483693
C015001arsenitearsenite affects the expression of PKN2 mRNA22959463
D001280AtrazineAtrazine results in increased expression of PKN2 mRNA22982499
C547126AZM551248AZM551248 results in decreased expression of PKN2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKN2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PKN2 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of PKN2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PKN2 mRNA26472689
D019327Copper SulfateCopper Sulfate results in increased expression of PKN2 mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PKN2 mRNA24317228
D013759DronabinolDronabinol results in increased expression of PKN2 mRNA16597638
D003907DexamethasoneDexamethasone results in decreased expression of PKN2 mRNA21041162
D002945CisplatinCisplatin results in increased expression of PKN2 mRNA21151649
D004317DoxorubicinDoxorubicin results in decreased expression of PKN2 mRNA17888722
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKN2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PKN2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PKN2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKN2 mRNA17942748
C049347fasudilfasudil results in decreased activity of PKN2 protein10998351
D005897GlafenineGlafenine results in decreased expression of PKN2 mRNA24136188
C544151jinfukangjinfukang results in decreased expression of PKN2 mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PKN2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PKN2 mRNA"26251327
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PKN2 mRNA19812364
D009538NicotineNicotine results in increased expression of PKN2 mRNA16949557
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PKN2 mRNA25729387
D010634PhenobarbitalPhenobarbital affects the expression of PKN2 mRNA23091169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKN2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PKN2 mRNA22079256
C059514resveratrolresveratrol results in decreased expression of PKN2 mRNA18089832
D012643SeleniumSelenium results in decreased expression of PKN2 mRNA19244175
D013629TamoxifenTamoxifen affects the expression of PKN2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKN2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKN2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PKN2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PKN2 mRNA17942748
D013853ThioacetamideThioacetamide results in increased expression of PKN2 mRNA23411599
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PKN2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PKN2 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PKN2 gene27618143
D014635Valproic AcidValproic Acid results in decreased expression of PKN2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PKN2 gene25560391
D014810Vitamin EVitamin E results in decreased expression of PKN2 mRNA19244175
C108830Y 27632Y 27632 results in decreased activity of PKN2 protein10998351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004672protein kinase activity-TAS7851406  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA20188095  
GO:0004697protein kinase C activity-IEA-  
GO:0005515protein binding-IPI10026169  11356191  15364941  17110931  20974804  27104747  
GO:0005524ATP binding-IEA-  
GO:0016301kinase activity-IDA15364941  
GO:0017049GTP-Rho binding-IEA-  
GO:0042826histone deacetylase binding-IDA20188095  
GO:0045296cadherin binding-HDA25468996  
GO:0070063RNA polymerase binding-IPI15364941  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IDA17332740  
GO:0006915apoptotic process-IEA-  
GO:0007049cell cycle-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007165signal transduction-TAS7851406  
GO:0010631epithelial cell migration-IDA21754995  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0030030cell projection organization-IEA-  
GO:0032467positive regulation of cytokinesis-IMP17332740  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0043297apical junction assembly-IMP20974804  
GO:0045070positive regulation of viral genome replication-IMP15364941  
GO:0045931positive regulation of mitotic cell cycle-IMP17332740  
GO:0051301cell division-IEA-  
GO:2000145regulation of cell motility-IMP21754995  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA11356191  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA17332740  
GO:0005813centrosome-IDA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0016604nuclear body-IDA-  
GO:0030027lamellipodium-IDA11356191  
GO:0030496midbody-IDA17332740  
GO:0032154cleavage furrow-IDA17332740  
GO:0032991protein-containing complex-IEA-  
GO:0043296apical junction complex-IDA20974804  
GO:0045111intermediate filament cytoskeleton-IDA-  
GO:0048471perinuclear region of cytoplasm-IDA15364941  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5625740RHO GTPases activate PKNsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29480433Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells. (2018 Feb 26)Rajagopalan PJ Cell Commun Signal