Gene: SLC22A11

55867
OAT4|hOAT4
solute carrier family 22 member 11
protein-coding
11q13.1
Ensembl:ENSG00000168065 MIM:607097 Vega:OTTHUMG00000045142 UniprotKB:Q9NSA0
NC_000011.10
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.494e-1 (AD)  7.300e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17300741chr11:64563990 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PITX30.656
IL220.651
SPO110.637
CA60.597
BPIFB30.59
TNFRSF12A0.586
CLCF10.582
C10orf1260.578
FBXO470.577
SPHK10.562

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.315
BCL11B-0.311
CNTN6-0.296
GPR17-0.287
TMEM179-0.285
KCNMB2-0.284
DRD5-0.284
ELFN2-0.279
SLC7A4-0.278
CASC15-0.277

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00168AspartameSmall Molecule22839-47-0Approved|NutraceuticalTransporter
DB00175PravastatinSmall Molecule81093-37-0ApprovedTransporter
DB00254DoxycyclineSmall Molecule564-25-0Approved|InvestigationalTransporter
DB00286Conjugated estrogensSmall Molecule12126-59-9ApprovedTransporter
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTransporter
DB00345Aminohippuric acidSmall Molecule61-78-9Approved|InvestigationalTransporter
DB00456CefalotinSmall Molecule153-61-7Approved|InvestigationalTransporter
DB00493CefotaximeSmall Molecule63527-52-6ApprovedTransporter
DB00495ZidovudineSmall Molecule30516-87-1ApprovedTransporter
DB00501CimetidineSmall Molecule51481-61-9Approved|InvestigationalTransporter
DB00554PiroxicamSmall Molecule36322-90-4Approved|InvestigationalTransporter
DB00563MethotrexateSmall Molecule59-05-2ApprovedTransporter
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTransporter
DB00595OxytetracyclineSmall Molecule79-57-2Approved|InvestigationalTransporter
DB00695FurosemideSmall Molecule54-31-9ApprovedTransporter
DB00759TetracyclineSmall Molecule60-54-8ApprovedTransporter
DB00783EstradiolSmall Molecule50-28-2Approved|InvestigationalTransporter
DB00812PhenylbutazoneSmall Molecule50-33-9ApprovedTransporter
DB00887BumetanideSmall Molecule28395-03-1ApprovedTransporter
DB00917DinoprostoneSmall Molecule363-24-6ApprovedTransporter
DB00936Salicylic acidSmall Molecule69-72-7Approved|InvestigationalTransporter
DB01009KetoprofenSmall Molecule22071-15-4ApprovedTransporter
DB01017MinocyclineSmall Molecule10118-90-8Approved|InvestigationalTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTransporter
DB01051NovobiocinSmall Molecule303-81-1Approved|InvestigationalTransporter
DB01053BenzylpenicillinSmall Molecule61-33-6ApprovedTransporter
DB01160Dinoprost TromethamineSmall Molecule38562-01-5ApprovedTransporter
DB01212CeftriaxoneSmall Molecule73384-59-5ApprovedTransporter
DB01326CefamandoleSmall Molecule34444-01-4Approved|InvestigationalTransporter
DB01327CefazolinSmall Molecule25953-19-9ApprovedTransporter
DB01329CefoperazoneSmall Molecule62893-19-0Approved|InvestigationalTransporter
DB03553Glutaric AcidSmall Molecule110-94-1ExperimentalTransporter
DB04133Degraded CephaloridineSmall Molecule-ExperimentalTransporter
DB04519Caprylic acidSmall Molecule124-07-2Approved|Experimental|InvestigationalTransporter
DB08846Ellagic AcidSmall Molecule476-66-4InvestigationalTransporter
DB13952Estradiol acetateSmall Molecule4245-41-4Approved|InvestigationalTransporter
DB13953Estradiol benzoateSmall Molecule50-50-0Approved|InvestigationalTransporter
DB13954Estradiol cypionateSmall Molecule313-06-4Approved|InvestigationalTransporter
DB13955Estradiol dienanthateSmall Molecule7732-97-0Approved|InvestigationalTransporter
DB13956Estradiol valerateSmall Molecule979-32-8Approved|InvestigationalTransporter
DB00493CefotaximeSmall Molecule63527-52-6ApprovedTarget
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTarget
DB01212CeftriaxoneSmall Molecule73384-59-5ApprovedTarget
DB11560LesinuradSmall Molecule878672-00-5Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0194924-methylumbelliferyl sulfate4-methylumbelliferyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C0233794-nitrophenyl sulfate4-nitrophenyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C0240986-carboxyfluoresceinglutaric acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]20639259
C0240986-carboxyfluoresceinp-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]20639259
C0240986-carboxyfluoresceinProbenecid inhibits the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]20639259
C0240986-carboxyfluoresceinProbenecid inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein]28597291
C0240986-carboxyfluoresceinSLC22A11 protein results in increased import of 6-carboxyfluorescein20639259
C0240986-carboxyfluoresceinSLC22A11 protein results in increased uptake of 6-carboxyfluorescein28597291
C0240986-carboxyfluoresceinSulpiride inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein]28597291
C0775807-(deoxyadenosin-N(6)-yl)aristolactam IProbenecid inhibits the reaction [[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
C0775807-(deoxyadenosin-N(6)-yl)aristolactam I[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I19643159
C0775797-(deoxyguanosin-N(2)-yl)aristolactam IProbenecid inhibits the reaction [[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
C0775797-(deoxyguanosin-N(2)-yl)aristolactam I[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I19643159
D000082AcetaminophenAcetaminophen results in decreased activity of SLC22A11 protein12388633
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC22A11 mRNA23402939
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC22A11 gene27153756
D016604Aflatoxin B1finrozole inhibits the reaction [Aflatoxin B1 results in increased expression of SLC22A11 mRNA]23402939
D010130p-Aminohippuric Acidaristolochic acid I promotes the reaction [SLC22A11 results in increased export of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric Acidestrone sulfate promotes the reaction [SLC22A11 results in increased export of p-Aminohippuric Acid]19643159
D010130p-Aminohippuric Acidp-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]20639259
D010130p-Aminohippuric Acidp-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
D010130p-Aminohippuric Acidp-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
D010130p-Aminohippuric AcidSLC22A11 results in increased export of p-Aminohippuric Acid19643159
C000228aristolochic acid Iaristolochic acid I inhibits the reaction [SLC22A11 results in increased uptake of estrone sulfate]19643159
C000228aristolochic acid Iaristolochic acid I promotes the reaction [SLC22A11 results in increased export of p-Aminohippuric Acid]19643159
D034341Aristolochic AcidsProbenecid inhibits the reaction [[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
D034341Aristolochic AcidsProbenecid inhibits the reaction [[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
D034341Aristolochic AcidsSLC22A11 results in increased uptake of Aristolochic Acids19643159
D034341Aristolochic Acids[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I19643159
D034341Aristolochic Acids[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I19643159
D001151ArsenicArsenic affects the methylation of SLC22A11 gene25304211
D001241AspirinAspirin results in decreased activity of SLC22A11 protein12388633
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC22A11 mRNA22079614
D002034BumetanideBumetanide inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C018475butyraldehydebutyraldehyde results in decreased expression of SLC22A11 mRNA26079696
D003345CorticosteroneCorticosterone inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C004742daidzeindaidzein inhibits the reaction [SLC22A11 protein results in increased transport of estrone sulfate]25319728
C004742daidzeindaidzein metabolite inhibits the reaction [SLC22A11 protein results in increased transport of estrone sulfate]25319728
C004742daidzeinestrone sulfate inhibits the reaction [SLC22A11 protein results in increased transport of daidzein metabolite]25319728
C004742daidzeinSLC22A11 protein results in increased transport of daidzein metabolite25319728
C014347decitabinedecitabine results in increased expression of SLC22A11 mRNA28597291
D019314Dehydroepiandrosterone SulfateSLC22A11 protein affects the transport of Dehydroepiandrosterone Sulfate10660625
D004008DiclofenacDiclofenac inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
D004008DiclofenacDiclofenac results in decreased activity of SLC22A11 protein12388633
D002117CalcitriolCalcitriol results in decreased expression of SLC22A11 mRNA27107558
C031555estradiol sulfateestradiol sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfate4-methylumbelliferyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfate4-nitrophenyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfatearistolochic acid I inhibits the reaction [SLC22A11 results in increased uptake of estrone sulfate]19643159
C017296estrone sulfateBumetanide inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateCorticosterone inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfatedaidzein inhibits the reaction [SLC22A11 protein results in increased transport of estrone sulfate]25319728
C017296estrone sulfatedaidzein metabolite inhibits the reaction [SLC22A11 protein results in increased transport of estrone sulfate]25319728
C017296estrone sulfateDiclofenac inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateestradiol sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateestrone sulfate inhibits the reaction [SLC22A11 protein results in increased transport of daidzein metabolite]25319728
C017296estrone sulfateestrone sulfate promotes the reaction [SLC22A11 results in increased export of p-Aminohippuric Acid]19643159
C017296estrone sulfateFurosemide inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateglutaric acid promotes the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateIbuprofen inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateIndomethacin inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfatenaphthyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateOxypurinol inhibits the reaction [SLC22A11 protein results in increased uptake of estrone sulfate]16135657
C017296estrone sulfatep-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateperfluorodecanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateperfluoro-n-heptanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateperfluoro-n-nonanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateperfluorooctanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateProbenecid inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateProbenecid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C017296estrone sulfateSLC22A11 protein affects the transport of estrone sulfate10660625
C017296estrone sulfateSLC22A11 protein results in increased import of estrone sulfate20639259
C017296estrone sulfateSLC22A11 protein results in increased uptake of estrone sulfate16135657
C017296estrone sulfateSLC22A11 results in increased uptake of estrone sulfate19643159
C017296estrone sulfateSulfobromophthalein inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C017296estrone sulfateUric Acid inhibits the reaction [SLC22A11 protein results in increased uptake of estrone sulfate]16135657
C111409finrozolefinrozole inhibits the reaction [Aflatoxin B1 results in increased expression of SLC22A11 mRNA]23402939
D005665FurosemideFurosemide inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
C035736glutaric acidglutaric acid promotes the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]20639259
C035736glutaric acidglutaric acid promotes the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C035736glutaric acidglutaric acid promotes the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
D007052IbuprofenIbuprofen inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
D007052IbuprofenIbuprofen results in decreased activity of SLC22A11 protein12388633
D007213IndomethacinIndomethacin inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
D007213IndomethacinIndomethacin results in decreased activity of SLC22A11 protein12388633
D007660KetoprofenKetoprofen results in decreased activity of SLC22A11 protein12388633
D007660KetoprofenSLC22A11 protein results in increased uptake of Ketoprofen12388633
D007854LeadLead results in increased expression of SLC22A11 mRNA19921347
D008528Mefenamic AcidMefenamic Acid results in decreased activity of SLC22A11 protein12388633
C029092naphthyl sulfatenaphthyl sulfate inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
D009288NaproxenNaproxen results in decreased activity of SLC22A11 protein12388633
C025589ochratoxin ASLC22A11 protein affects the transport of ochratoxin A10660625
D010117OxypurinolOxypurinol inhibits the reaction [SLC22A11 protein results in increased uptake of estrone sulfate]16135657
C036567perfluorodecanoic acidperfluorodecanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C023036perfluorooctanoic acidglutaric acid promotes the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
C023036perfluorooctanoic acidp-Aminohippuric Acid promotes the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
C023036perfluorooctanoic acidperfluorooctanoic acid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
C023036perfluorooctanoic acidProbenecid inhibits the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
C023036perfluorooctanoic acidSLC22A11 protein results in increased import of perfluorooctanoic acid20639259
C023036perfluorooctanoic acidSulfobromophthalein inhibits the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
D010615PhenacetinPhenacetin results in decreased activity of SLC22A11 protein12388633
D010894PiroxicamPiroxicam results in decreased activity of SLC22A11 protein12388633
D011339ProbenecidProbenecid inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
D011339ProbenecidProbenecid inhibits the reaction [SLC22A11 protein results in increased import of 6-carboxyfluorescein]20639259
D011339ProbenecidProbenecid inhibits the reaction [SLC22A11 protein results in increased import of estrone sulfate]20639259
D011339ProbenecidProbenecid inhibits the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
D011339ProbenecidProbenecid inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein]28597291
D011339ProbenecidProbenecid inhibits the reaction [[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]19643159
D011339ProbenecidProbenecid inhibits the reaction [[SLC22A11 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]19643159
C502851quinocetonequinocetone results in increased expression of SLC22A11 mRNA27046791
D020156Salicylic AcidSalicylic Acid results in decreased activity of SLC22A11 protein12388633
D020156Salicylic AcidSLC22A11 protein results in increased uptake of Salicylic Acid12388633
D018038Sodium SeleniteSodium Selenite results in decreased expression of SLC22A11 mRNA18175754
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLC22A11 protein affects the transport of estrone sulfate]10660625
D013448SulfobromophthaleinSulfobromophthalein inhibits the reaction [SLC22A11 protein results in increased import of perfluorooctanoic acid]20639259
D013467SulindacSulindac results in decreased activity of SLC22A11 protein12388633
D013469SulpirideSulpiride inhibits the reaction [SLC22A11 protein results in increased uptake of 6-carboxyfluorescein]28597291
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SLC22A11 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of SLC22A11 mRNA25572481
D014527Uric AcidUric Acid inhibits the reaction [SLC22A11 protein results in increased uptake of estrone sulfate]16135657

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005452inorganic anion exchanger activity-IDA15037815  
GO:0005515protein binding-IPI16236806  
GO:0008514organic anion transmembrane transporter activity-IDA15102942  15291761  18501590  
GO:0015347sodium-independent organic anion transmembrane transporter activity-IDA10660625  
GO:0015347sodium-independent organic anion transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015698inorganic anion transport-IEA-  
GO:0015711organic anion transport-IDA10660625  15291761  
GO:0046415urate metabolic process-IMP19503597  
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA10660625  
GO:0009897external side of plasma membrane-IDA15102942  
GO:0016324apical plasma membrane-IDA15037815  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-549132Organic cation/anion/zwitterion transportTAS
R-HSA-561048Organic anion transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal