Gene: GSDMB

55876
GSDML|PP4052|PRO2521
gasdermin B
protein-coding
17q21.1
Ensembl:ENSG00000073605 MIM:611221 Vega:OTTHUMG00000133248 UniprotKB:Q8TAX9
NG_015804.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.609e-1 (AD)  7.012e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGF170.896
TNFRSF250.864
ZGLP10.86
CPT1B0.822
ZNF6920.816
RCE10.816
OSBPL70.814
PLK10.814
SLC43A10.812
HSF40.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.408
OR4F29-0.382
PDE11A-0.315
IRX3-0.292
CALCR-0.287
GSDMC-0.285
SETD9-0.285
ARHGAP36-0.283
AGTR1-0.283
ADAMTS5-0.279

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of GSDMB mRNA21420995
C584509C646 compoundC646 compound results in increased expression of GSDMB mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of GSDMB mRNA25979313
D016572CyclosporineCyclosporine results in decreased expression of GSDMB mRNA20106945
D002945CisplatinCisplatin results in decreased expression of GSDMB mRNA27594783
C492448ICG 001ICG 001 results in increased expression of GSDMB mRNA26191083
C045463leflunomideleflunomide results in increased expression of GSDMB mRNA28988120
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of GSDMB mRNA24810058
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of GSDMB mRNA22108045
D011794QuercetinQuercetin results in increased expression of GSDMB mRNA21632981
D012906SmokeSmoke results in increased expression of GSDMB mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSDMB mRNA21632981
D019284ThapsigarginThapsigargin results in increased expression of GSDMB mRNA22378314
C012589trichostatin Atrichostatin A affects the expression of GSDMB mRNA28542535
D014635Valproic AcidValproic Acid results in decreased expression of GSDMB mRNA23179753
D015032ZincZinc deficiency results in decreased expression of GSDMB mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IBA21873635  
GO:0003674molecular_function-ND-  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IBA21873635  
GO:0070273phosphatidylinositol-4-phosphate binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO:0012501programmed cell death-IEA-  
GO:0042742defense response to bacterium-IBA21873635  
GO:0070269pyroptosis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
2262659217q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom. (2012 Jun)Marinho SAnn Allergy Asthma Immunol
2362200517q12-21 and asthma: interactions with early-life environmental exposures. (2013 May)Blekic MAnn Allergy Asthma Immunol
28120299Analysis of rs8067378 Polymorphism in the Risk of Uterine Cervical Cancer from a Polish Population and its Impact on Gasdermin B Expression. (2017 Apr)Lutkowska AMol Diagn Ther