Gene info: ID 5588

Gene: PRKCQ

GENE ID: 5588

Synonyms: PRKCT|nPKC-theta

Description: protein kinase C theta

Gene type: protein-coding

Location: 10p15.1

dbXrefs: Ensembl:ENSG00000065675 MIM:600448 Vega:OTTHUMG00000017623 UniprotKB:Q04759

RefSeq: NC_000010.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.496e-1 (AD) 7.664e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNTN2	0.847
PDE1C	0.835
CARNS1	0.827
TF	0.825
KIAA1324L	0.812
ZNF536	0.811
SLC22A15	0.811
TMEM125	0.806
MAG	0.802
GJB1	0.802

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPRY1	-0.395
DDIT4L	-0.39
NR2F2	-0.378
SYPL2	-0.366
CASP7	-0.36
MTRNR2L8	-0.359
WTIP	-0.358
EVC2	-0.354
ZIC5	-0.349
NR2E1	-0.346

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB02010	Staurosporine	Small Molecule	62996-74-1	Experimental	Target
DB02482	Phosphonothreonine	Small Molecule		Experimental	Target
DB04522	Dexfosfoserine	Small Molecule	407-41-0	Experimental	Target
DB00675	Tamoxifen	Small Molecule	10540-29-1	Approved	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRKCQ mRNA"	25614096
C575152	(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate	(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [glutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCQ protein]	24021941
C575152	(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate	"(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCQ protein]"	24021941
D000082	Acetaminophen	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PRKCQ mRNA	17093179
D020106	Acrylamide	Acrylamide affects the expression of PRKCQ mRNA	28959563
D000393	Air Pollutants	Air Pollutants results in decreased expression of PRKCQ mRNA	25056781
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PRKCQ mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of PRKCQ gene	25304211
D001151	Arsenic	[Coal results in increased abundance of Arsenic] which results in decreased expression of and results in decreased phosphorylation of PRKCQ protein	28823652
D001205	Ascorbic Acid	[Tretinoin co-treated with Ascorbic Acid] results in increased expression of PRKCQ mRNA	16443354
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of PRKCQ mRNA	27377005
D000069059	Atorvastatin Calcium	Atorvastatin Calcium results in increased expression of PRKCQ protein	27377005
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of PRKCQ mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKCQ mRNA	21871943
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKCQ mRNA	21569818
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in increased expression of PRKCQ mRNA	20660070
C006780	bisphenol A	bisphenol A affects the expression of PRKCQ mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of PRKCQ mRNA	25181051
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in decreased expression of PRKCQ mRNA	18958704
D020001	1-Butanol	1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCQ protein]	15843515
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PRKCQ mRNA	27509014
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased methylation of PRKCQ gene	27509014
D003031	Coal	[Coal results in increased abundance of Arsenic] which results in decreased expression of and results in decreased phosphorylation of PRKCQ protein	28823652
D060729	Coal Ash	Coal Ash results in increased expression of PRKCQ mRNA	19000753
D003300	Copper	Copper results in decreased expression of PRKCQ mRNA	22465980
D003474	Curcumin	Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein]	26713546
D016572	Cyclosporine	Cyclosporine results in increased methylation of PRKCQ promoter	27989131
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of PRKCQ mRNA	24317228
D003976	Diazinon	Diazinon results in decreased expression of PRKCQ mRNA	17452286
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PRKCQ mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of PRKCQ mRNA	27392435
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of PRKCQ mRNA	26924002
D004040	Dietary Carbohydrates	[Dietary Carbohydrates co-treated with Acetaminophen] results in decreased expression of PRKCQ mRNA	17093179
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of PRKCQ mRNA	26924002
D004237	Diuron	Diuron results in increased expression of PRKCQ mRNA	25152437
C118739	entinostat	entinostat results in increased expression of PRKCQ mRNA	27188386
D000431	Ethanol	Ethanol results in increased expression of PRKCQ mRNA	20655511
D005632	Fructose	Curcumin inhibits the reaction [Fructose results in increased phosphorylation of PRKCQ protein]	26713546
D005632	Fructose	Fructose results in increased phosphorylation of PRKCQ protein	26713546
D005839	Gentamicins	Gentamicins results in increased expression of PRKCQ mRNA	22061828
C524061	glutathionyl 4-hydroxy-2-nonenal conjugate	(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [glutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCQ protein]	24021941
C524061	glutathionyl 4-hydroxy-2-nonenal conjugate	glutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCQ protein	24021941
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased activity of PRKCQ protein	12626342
D015759	Ionomycin	pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein]	16241859
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein	16241859
C008261	lead acetate	lead acetate results in decreased expression of PRKCQ mRNA	22613225
C482199	lipopolysaccharide, E coli O55-B5	"(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCQ protein]"	24021941
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCQ protein"	24021941
D008628	Mercury	Mercury analog results in decreased expression of PRKCQ mRNA	25056781
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PRKCQ mRNA	26011545
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PRKCQ mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PRKCQ mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of PRKCQ mRNA	24768652\|2558310
D009534	Niclosamide	Niclosamide results in increased expression of PRKCQ mRNA	22576131
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PRKCQ mRNA	27935865
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PRKCQ mRNA	25729387
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PRKCQ mRNA	27935865
C467566	pomalidomide	pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein]	16241859
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in increased expression of PRKCQ mRNA	20660070
D011374	Progesterone	Progesterone results in decreased expression of PRKCQ mRNA	19690047
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PRKCQ mRNA	24780913
C034912	puag-haad	puag-haad results in increased expression of PRKCQ mRNA	28780155
D011794	Quercetin	Quercetin inhibits the reaction [IL1A protein results in increased expression of PRKCQ protein modified form]	16532021
D011794	Quercetin	Quercetin results in increased expression of PRKCQ mRNA	15309432
C059514	resveratrol	resveratrol results in decreased expression of PRKCQ protein	17112897
C059514	resveratrol	resveratrol results in decreased phosphorylation of and results in decreased activity of PRKCQ protein	23514766
C085746	rottlerin	rottlerin results in decreased activity of PRKCQ protein	15691325
C017947	sodium arsenite	sodium arsenite affects the methylation of PRKCQ gene	28589171
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of PRKCQ mRNA	21340527
D018038	Sodium Selenite	Sodium Selenite results in decreased expression of PRKCQ mRNA	23274088
D053260	Soot	Soot results in decreased expression of PRKCQ mRNA	26551751
D020002	tert-Butyl Alcohol	tert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCQ protein]	15843515
D013749	Tetrachlorodibenzodioxin	PRKCQ protein mutant form results in decreased susceptibility to Tetrachlorodibenzodioxin	15691325
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the localization of PRKCQ protein	15691325
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [VAV1 protein binds to PRKCQ protein]	20561557
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of PRKCQ protein	15691325
D013755	Tetradecanoylphorbol Acetate	pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein]	16241859
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein	16241859
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased localization of PRKCQ protein	15843515
D019284	Thapsigargin	1-Butanol inhibits the reaction [Thapsigargin results in increased localization of PRKCQ protein]	15843515
D019284	Thapsigargin	tert-Butyl Alcohol inhibits the reaction [Thapsigargin results in increased localization of PRKCQ protein]	15843515
D019284	Thapsigargin	Thapsigargin results in increased localization of PRKCQ protein	15843515
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PRKCQ mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with Ascorbic Acid] results in increased expression of PRKCQ mRNA	16443354
C012589	trichostatin A	trichostatin A results in increased expression of PRKCQ mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PRKCQ mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PRKCQ mRNA	23179753\|2438349
D014639	Vanadium	Vanadium results in decreased expression of PRKCQ mRNA	19000753

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004672	protein kinase activity	-	TAS	-
GO:0004674	protein serine/threonine kinase activity	-	EXP	16356856
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	NAS	8444877
GO:0004674	protein serine/threonine kinase activity	-	TAS	-
GO:0004697	protein kinase C activity	-	IEA	-
GO:0005515	protein binding	-	IPI	10383400 10636891 11788586 15254234 17588663 21964608 21983831 23352416
GO:0005524	ATP binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	NAS	8444877
GO:0006355	regulation of transcription, DNA-templated	-	ISS	-
GO:0006509	membrane protein ectodomain proteolysis	-	ISS	-
GO:0006954	inflammatory response	-	IEA	-
GO:0007411	axon guidance	-	TAS	-
GO:0018105	peptidyl-serine phosphorylation	-	IBA	21873635
GO:0030168	platelet activation	-	TAS	-
GO:0032212	positive regulation of telomere maintenance via telomerase	-	IMP	21531765
GO:0032740	positive regulation of interleukin-17 production	-	ISS	-
GO:0032753	positive regulation of interleukin-4 production	-	ISS	-
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0035556	intracellular signal transduction	-	NAS	7686153
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	-
GO:0042102	positive regulation of T cell proliferation	-	IEA	-
GO:0045086	positive regulation of interleukin-2 biosynthetic process	-	IEA	-
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	-
GO:0046627	negative regulation of insulin receptor signaling pathway	-	IMP	15364919
GO:0050852	T cell receptor signaling pathway	-	TAS	-
GO:0050870	positive regulation of T cell activation	-	ISS	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IDA	16356855
GO:0051973	positive regulation of telomerase activity	-	IMP	21531765
GO:0060326	cell chemotaxis	-	IMP	24008408
GO:0070233	negative regulation of T cell apoptotic process	-	IMP	11342610 16709830
GO:0090330	regulation of platelet aggregation	-	ISS	-
GO:1904355	positive regulation of telomere capping	-	IMP	21531765
GO:2000318	positive regulation of T-helper 17 type immune response	-	ISS	-
GO:2000570	positive regulation of T-helper 2 cell activation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001772	immunological synapse	-	IEA	-
GO:0005815	microtubule organizing center	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	TAS	-
GO:0016235	aggresome	-	IDA	-

KEGG ID	KEGG Term
hsa04270	Vascular smooth muscle contraction
hsa04530	Tight junction
hsa04660	T cell receptor signaling pathway
hsa04920	Adipocytokine signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-109581	Apoptosis	TAS
R-HSA-109582	Hemostasis	TAS
R-HSA-111465	Apoptotic cleavage of cellular proteins	TAS
R-HSA-114508	Effects of PIP2 hydrolysis	TAS
R-HSA-1266738	Developmental Biology	TAS
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168249	Innate Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-202403	TCR signaling	TAS
R-HSA-202424	Downstream TCR signaling	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2187338	Visual phototransduction	IEA
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	TAS
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	IEA
R-HSA-2514856	The phototransduction cascade	IEA
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	IEA
R-HSA-2871837	FCERI mediated NF-kB activation	TAS
R-HSA-2871837	FCERI mediated NF-kB activation	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373752	Netrin-1 signaling	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418594	G alpha (i) signalling events	IEA
R-HSA-418597	G alpha (z) signalling events	IEA
R-HSA-422475	Axon guidance	TAS
R-HSA-5357801	Programmed Cell Death	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-75153	Apoptotic execution phase	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-8878171	Transcriptional regulation by RUNX1	TAS
R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20439292	Genetic variants in the prediction of rheumatoid arthritis. (2010 Sep)	van der Helm-van Mil AH	Ann Rheum Dis