Gene: PRKCZ

5590
PKC-ZETA|PKC2
protein kinase C zeta
protein-coding
1p36.33
Ensembl:ENSG00000067606 MIM:176982 Vega:OTTHUMG00000001238 UniprotKB:Q05513
NG_029616.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.983e-1 (AD)  5.606e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04023573chr1:2004636PRKCZPromoter9.047e-5Alcohol use disorders26763658
cg03580279chr1:2015974PRKCZPromoter6.590e-4Alcohol use disorders26763658
cg24842354chr1:2004057PRKCZ7.200e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYN20.954
C1orf2160.953
GNG30.95
SVOP0.949
KIF3C0.948
ARHGAP440.948
ACTR3B0.947
SYP0.946
REPS20.945
ATCAY0.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.574
KCNJ15-0.556
RUNX3-0.556
CSAG1-0.545
IL18RAP-0.54
REST-0.537
WWTR1-0.533
TFPI2-0.532
IL2RG-0.531
LATS2-0.53

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00675TamoxifenSmall Molecule10540-29-1ApprovedTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PRKCZ mRNA"28903501
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine affects the localization of and results in increased activity of PRKCZ protein12590138
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosinePRKCZ protein affects the reaction [[2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine binds to and results in increased activity of ADORA2A protein] which results in decreased expression of VEGFA mRNA]12590138
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosinePRKCZ protein affects the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased expression of VEGFA mRNA]12590138
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PRKCZ mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]15958164
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein]15958164
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of PRKCZ protein15735031
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of PRKCZ protein12970779
C0299552-nitrotoluene2-nitrotoluene results in increased expression of PRKCZ mRNA16460773
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PRKCZ mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of PRKCZ mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PRKCZ mRNA21420995
D000143AcidsPRKCZ protein alternative form results in increased susceptibility to Acids27899695
C016601afimoxifenePRKCZ results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PRKCZ protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PRKCZ mRNA22100608|2715375
C031143AICA ribonucleotide1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
C031143AICA ribonucleotide2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
C031143AICA ribonucleotideAICA ribonucleotide results in increased activity of PRKCZ protein11978788
C031143AICA ribonucleotideGenistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
C031143AICA ribonucleotideGRB2 protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
C031143AICA ribonucleotidePTK2B protein affects the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKCZ mRNA16483693
D000661AmphetamineAmphetamine affects the expression of PRKCZ mRNA16101753
D001151ArsenicArsenic affects the methylation of PRKCZ gene25304211
C006632arsenic trioxidePRKCZ mRNA affects the susceptibility to arsenic trioxide23911876
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased activity of PRKCZ protein"12626342
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PRKCZ protein"12626342
C547126AZM551248AZM551248 results in decreased expression of PRKCZ mRNA22323515
C044887beta-methylcholinebeta-methylcholine affects the expression of PRKCZ mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of PRKCZ protein23545179
C006780bisphenol Abisphenol A results in decreased expression of PRKCZ mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in increased expression of PRKCZ mRNA16460773
D0200011-Butanol1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein]15255942
D0200011-Butanol1-Butanol inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
D002101Cacodylic AcidCacodylic Acid results in increased expression of PRKCZ mRNA16122865
D002104CadmiumCadmium results in increased expression of PRKCZ mRNA24376830
D002211CapsaicinPRKCZ protein alternative form results in increased susceptibility to Capsaicin27899695
D002217Carbachol1-Butanol inhibits the reaction [Carbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein]15255942
D002217CarbacholCarbachol results in increased activity of PRKCZ protein15255942
D002217CarbacholCarbachol results in increased phosphorylation of and results in increased activity of PRKCZ protein15255942
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PRKCZ mRNA16644059
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PRKCZ mRNA17032414
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PRKCZ mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of PRKCZ mRNA17585979|2381119
D003000Clonidine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]15958164
D003000ClonidineClonidine results in increased phosphorylation of PRKCZ protein15958164
D003000ClonidineYohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]15958164
D003024ClozapineClozapine results in increased expression of PRKCZ mRNA15860345
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PRKCZ mRNA18355967
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PRKCZ mRNA]11007951
D016572CyclosporineCyclosporine results in decreased methylation of PRKCZ promoter27989131
D016572CyclosporineCyclosporine results in increased expression of PRKCZ mRNA25562108
D003561CytarabinePRKCZ protein results in decreased susceptibility to Cytarabine21863889
D003630DaunorubicinPRKCZ protein results in decreased susceptibility to Daunorubicin21863889
D003840Deoxycholic AcidPRKCZ protein results in decreased susceptibility to Deoxycholic Acid12507930
D003976DiazinonDiazinon results in increased methylation of PRKCZ gene22964155
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of PRKCZ mRNA]27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of PRKCZ mRNA]27392435
D004052DiethylnitrosamineDiethylnitrosamine results in increased phosphorylation of PRKCZ protein21056072
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PRKCZ mRNA17032414
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of PRKCZ mRNA25198161
D000431EthanolEthanol results in decreased expression of PRKCZ mRNA20655511
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCZ mRNA17942748
D005047EtoposidePRKCZ protein results in increased susceptibility to Etoposide21863889
D005411Flame RetardantsFlame Retardants affects the localization of PRKCZ protein15475174
D005472FluorouracilFluorouracil affects the expression of PRKCZ mRNA16584549
D005557FormaldehydePRKCZ protein alternative form results in increased susceptibility to Formaldehyde27899695
D019833GenisteinGenistein inhibits the reaction [AICA ribonucleotide results in increased activity of PRKCZ protein]11978788
D005947GlucosePRKCZ protein promotes the reaction [NRG1 protein results in increased transport of Glucose]14711829
C524061glutathionyl 4-hydroxy-2-nonenal conjugateglutathionyl 4-hydroxy-2-nonenal conjugate results in increased phosphorylation of PRKCZ protein24021941
D006220HaloperidolHaloperidol results in increased expression of PRKCZ mRNA15860345
D017313FenretinideFenretinide results in decreased expression of PRKCZ mRNA28973697
D017313FenretinideFenretinide results in increased expression of PRKCZ mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased activity of PRKCZ protein12626342
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PRKCZ protein12626342
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of PRKCZ mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of PRKCZ mRNA]27392435
C410337K 7174K 7174 results in increased expression of PRKCZ mRNA24086573
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of PRKCZ mRNA"24972896
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of PRKCZ protein"24021941
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of PRKCZ protein20920494
D008070LipopolysaccharidesPRKCZ protein promotes the reaction [Lipopolysaccharides affects the localization of NCF1 protein]20920494
D008070LipopolysaccharidesPRKCZ protein promotes the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]20920494
D008070LipopolysaccharidesPRKCZ protein promotes the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]20920494
D008070LipopolysaccharidesPRKCZ protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of NCF1 protein]20920494
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of PRKCZ mRNA18386188
D008687MetforminMetformin results in increased phosphorylation of PRKCZ protein19236843
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of PRKCZ protein11794376
C030667methylazoxymethanolmethylazoxymethanol results in increased expression of PRKCZ mRNA17107856
C005219methyl cellosolvemethyl cellosolve metabolite results in increased expression of PRKCZ protein11794376
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PRKCZ mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRKCZ mRNA"20188158
D016685MitomycinMitomycin results in increased cleavage of PRKCZ protein10960761
C568285myristoylated zeta-pseudosubstrate inhibitory peptidemyristoylated zeta-pseudosubstrate inhibitory peptide results in decreased phosphorylation of PRKCZ protein alternative form27899695
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PRKCZ mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKCZ mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PRKCZ mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRKCZ mRNA"25554681
D009532NickelNickel results in increased expression of PRKCZ mRNA14575637
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of PRKCZ mRNA]14575637
D009538NicotineNicotine results in increased activity of PRKCZ protein17525161
D009538NicotinePRKCZ protein affects the reaction [Nicotine results in increased phosphorylation of BAX protein]17525161
C511689(N)-methanocarba-2MeSADPPRKCZ protein inhibits the reaction [(N)-methanocarba-2MeSADP results in increased phosphorylation of and results in increased activity of AKT1 protein]16236484
D009638Norepinephrine2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein]15958164
D009638NorepinephrineNorepinephrine results in increased phosphorylation of PRKCZ protein15958164
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of PRKCZ mRNA18386188
C086401pentabromodiphenyl etherpentabromodiphenyl ether affects the localization of PRKCZ protein15475174
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased phosphorylation of and results in decreased expression of PRKCZ protein26456889
D010656PhenylephrinePhenylephrine results in increased expression of PRKCZ protein17122163
D010656PhenylephrinePhenylephrine results in increased phosphorylation of PRKCZ protein17122163
D010656PhenylephrineGLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein]16809552
D010656PhenylephrinePhenylephrine affects the localization of PRKCZ protein14736339
D010656PhenylephrinePhenylephrine results in decreased activity of PRKCZ protein14736339
D010656PhenylephrinePhenylephrine results in increased phosphorylation of and results in increased activity of PRKCZ protein16809552
D010656PhenylephrinePhenylephrine results in increased phosphorylation of PRKCZ protein27094369
D010656PhenylephrinePRKCZ protein affects the reaction [Phenylephrine results in increased expression of AGT mRNA]27094369
D010656PhenylephrinePRKCZ protein affects the reaction [Phenylephrine results in increased expression of FOS mRNA]27094369
D010656PhenylephrinePRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]27094369
D010656PhenylephrinePRKCZ protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094369
D010656PhenylephrinePRKCZ protein affects the reaction [Phenylephrine results in increased phosphorylation of and affects the localization of STAT3 protein]27094369
D015240Phorbol 12,13-Dibutyrate"Phorbol 12,13-Dibutyrate results in increased expression of PRKCZ protein"12626342
D010712Phosphatidic AcidsPhosphatidic Acids results in increased phosphorylation of and results in increased activity of PRKCZ protein15255942
D010712Phosphatidic AcidsPhosphatidic Acids results in increased activity of PRKCZ protein11978788
D010862PilocarpinePilocarpine results in increased expression of PRKCZ protein15058486
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKCZ mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PRKCZ mRNA20059764|2381119
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of PRKCZ mRNA]20059764
D028321Plant PreparationsPlant Preparations results in decreased expression of PRKCZ mRNA24973489
D011374ProgesteroneProgesterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCZ protein]18615583
D011441PropylthiouracilPropylthiouracil results in decreased expression of PRKCZ mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in decreased activity of PRKCZ protein26833564
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in decreased expression of AGER protein26833564
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in decreased expression of AQP5 protein26833564
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in decreased expression of PDPN protein26833564
D047428Protein Kinase Inhibitors[Protein Kinase Inhibitors results in decreased activity of PRKCZ protein] which results in increased expression of SFTPC protein26833564
D011794QuercetinQuercetin results in decreased expression of PRKCZ mRNA26076811
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA19059307
C013672riddelliineriddelliine results in increased expression of PRKCZ mRNA18047727
C089730rosiglitazonerosiglitazone inhibits the reaction [AGT protein results in increased phosphorylation of PRKCZ protein]25874449
D012645SelenomethionineSelenomethionine affects the expression of PRKCZ mRNA17222674
C002979selenomethylselenocysteineselenomethylselenocysteine results in decreased expression of PRKCZ protein10656618
D012834SilverSilver results in decreased expression of PRKCZ mRNA21611810
D012834SilverSilver results in decreased expression of PRKCZ protein21611810
D012834SilverPRKCZ protein results in decreased susceptibility to Silver21611810
C017947sodium arsenitesodium arsenite results in increased expression of PRKCZ mRNA17879257
D018038Sodium SeleniteSodium Selenite results in increased expression of PRKCZ mRNA18175754
D013605T-2 ToxinT-2 Toxin results in decreased expression of PRKCZ mRNA26141394
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA19059307
D013739TestosteroneTestosterone inhibits the reaction [C3 protein results in increased phosphorylation of PRKCZ protein]18615583
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PRKCZ mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKCZ mRNA11007951
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKCZ mRNA17942748
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of PRKCZ protein15976015
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PRKCZ protein modified form16532021
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCZ protein12590138
D014050TolueneToluene affects the expression of PRKCZ mRNA21827849
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of PRKCZ mRNA]14575637
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PRKCZ mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of PRKCZ mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PRKCZ mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PRKCZ mRNA23527032
D014635Valproic AcidValproic Acid results in increased methylation of PRKCZ gene29154799
D014635Valproic AcidValproic Acid affects the expression of PRKCZ mRNA17292431
D014638VanadatesVanadates results in increased expression of PRKCZ protein17874149
D014639VanadiumVanadium affects the localization of PRKCZ protein14971662
D014640VancomycinVancomycin results in increased expression of PRKCZ mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRKCZ gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PRKCZ mRNA20566332
C029297vinylidene chloridevinylidene chloride results in decreased expression of PRKCZ mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PRKCZ mRNA"25198161
D015016YohimbineYohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]15958164

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA10770950  
GO:0004674protein serine/threonine kinase activity-EXP12391145  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA15069075  
GO:0004697protein kinase C activity-TAS-  
GO:0005515protein binding-IPI10831594  11260256  11755531  12893243  14676191  15707389  
16189514  16792529  17057644  17203073  17313651  17350623  
17588663  18190796  18650932  22939624  24375676  25011391  
25241761  25852190  27040869  27107012  
GO:0005524ATP binding-IEA-  
GO:0015459potassium channel regulator activity-IEA-  
GO:0019901protein kinase binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0043274phospholipase binding-IEA-  
GO:0043560insulin receptor substrate binding-IC15069075  
GO:0046872metal ion binding-IEA-  
GO:007188914-3-3 protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IEA-  
GO:0001954positive regulation of cell-matrix adhesion-IEA-  
GO:0006468protein phosphorylation-IDA10770950  17313651  
GO:0006954inflammatory response-IEA-  
GO:0007165signal transduction-TAS8224878  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007616long-term memory-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0008286insulin receptor signaling pathway-IEA-  
GO:0016477cell migration-IEA-  
GO:0018105peptidyl-serine phosphorylation-IBA21873635  
GO:0018105peptidyl-serine phosphorylation-IDA15069075  
GO:0030010establishment of cell polarity-ISS-  
GO:0031333negative regulation of protein complex assembly-IMP15069075  
GO:0031532actin cytoskeleton reorganization-IEA-  
GO:0031584activation of phospholipase D activity-IEA-  
GO:0032148activation of protein kinase B activity-IEA-  
GO:0032753positive regulation of interleukin-4 production-ISS-  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045630positive regulation of T-helper 2 cell differentiation-ISS-  
GO:0046326positive regulation of glucose import-IEA-  
GO:0046627negative regulation of insulin receptor signaling pathway-IMP15069075  
GO:0046628positive regulation of insulin receptor signaling pathway-ISS-  
GO:0047496vesicle transport along microtubule-IEA-  
GO:0050732negative regulation of peptidyl-tyrosine phosphorylation-IMP15069075  
GO:0051092positive regulation of NF-kappaB transcription factor activity-ISS-  
GO:0051291protein heterooligomerization-IEA-  
GO:0051346negative regulation of hydrolase activity-IEA-  
GO:0051899membrane depolarization-IEA-  
GO:0060081membrane hyperpolarization-IEA-  
GO:0060291long-term synaptic potentiation-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP11035106  
GO:0070528protein kinase C signaling-IEA-  
GO:0072659protein localization to plasma membrane-IEA-  
GO:1990138neuron projection extension-IEA-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO:2000553positive regulation of T-helper 2 cell cytokine production-ISS-  
GO:2000664positive regulation of interleukin-5 secretion-ISS-  
GO:2000667positive regulation of interleukin-13 secretion-ISS-  
GO:2001181positive regulation of interleukin-10 secretion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IEA-  
GO:0005737cytoplasm-TAS7925449  
GO:0005768endosome-IEA-  
GO:0005815microtubule organizing center-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005911cell-cell junction-IDA20332120  
GO:0005923bicellular tight junction-IEA-  
GO:0016020membrane-TAS7925449  
GO:0016324apical plasma membrane-IEA-  
GO:0016363nuclear matrix-IEA-  
GO:0030054cell junction-TAS-  
GO:0031252cell leading edge-IEA-  
GO:0031941filamentous actin-IEA-  
GO:0031982vesicle-IDA17313651  
GO:0035748myelin sheath abaxonal region-IEA-  
GO:0043203axon hillock-IEA-  
GO:0045121membrane raft-IEA-  
GO:0045179apical cortex-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04144Endocytosis
hsa04530Tight junction
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-114604GPVI-mediated activation cascadeIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-194138Signaling by VEGFTAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)TAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)IEA
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-5218921VEGFR2 mediated cell proliferationTAS
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics