Gene: ACSS2

55902
ACAS2|ACECS|ACS|ACSA|dJ1161H23.1
acyl-CoA synthetase short chain family member 2
protein-coding
20q11.22
Ensembl:ENSG00000131069 MIM:605832 Vega:OTTHUMG00000032317 UniprotKB:Q9NR19
NG_011520.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.105e-1 (AD)  8.904e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF3C50.89
AFMID0.871
PIGT0.87
NACAD0.864
PIGU0.861
HID10.858
SMG90.858
AATK0.856
CYTH10.856
MRPS50.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.591
OR4F29-0.566
FOXL1-0.285
MTRNR2L9-0.273
KLRB1-0.269
MTRNR2L6-0.265
FHL5-0.258
LRAT-0.256
ASB4-0.253
DIO2-0.253

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACSS2 mRNA"28903501
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSS2 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ACSS2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACSS2 mRNA"21346803
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of ACSS2 mRNA"24172598
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ACSS2 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of ACSS2 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of ACSS2 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ACSS2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ACSS2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ACSS2 mRNA21641981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ACSS2 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of ACSS2 mRNA21757418
D000452AldrinAldrin results in increased expression of ACSS2 mRNA18579281
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ACSS2 mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of ACSS2 mRNA25064622
D000638AmiodaroneAmiodarone results in increased expression of ACSS2 mRNA24535564
C006632arsenic trioxidearsenic trioxide results in decreased expression of ACSS2 mRNA27829220
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSS2 mRNA22178795|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSS2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ACSS2 mRNA19770486|2196490
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in increased expression of ACSS2 mRNA]28476547
D004958EstradiolEstradiol results in decreased expression of ACSS2 mRNA19484750
D004958EstradiolEstradiol results in increased expression of ACSS2 mRNA28476547
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ACSS2 mRNA26496021
D001629BezafibrateBezafibrate affects the expression of ACSS2 mRNA17719200
C006780bisphenol Abisphenol A affects the expression of ACSS2 mRNA21786754
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in increased expression of ACSS2 mRNA]28476547
C006780bisphenol Abisphenol A results in increased expression of ACSS2 mRNA28476547
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSS2 mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ACSS2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ACSS2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ACSS2 mRNA23644582
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ACSS2 mRNA27339419
D002737ChloropreneChloroprene results in increased expression of ACSS2 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of ACSS2 mRNA25064622
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ACSS2 mRNA24690739
D019327Copper SulfateCopper Sulfate results in decreased expression of ACSS2 mRNA19549813
C029892cupric chloridecupric chloride results in decreased expression of ACSS2 mRNA24650576
D016572CyclosporineCyclosporine affects the expression of ACSS2 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of ACSS2 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in increased expression of ACSS2 mRNA27989131
D016572CyclosporineCyclosporine results in decreased expression of ACSS2 mRNA23830897
D016572CyclosporineCyclosporine results in decreased expression of ACSS2 mRNA21865292
D003907DexamethasoneDexamethasone results in increased expression of ACSS2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ACSS2 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ACSS2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ACSS2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ACSS2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ACSS2 mRNA27594783
D004041Dietary FatsDietary Fats affects the expression of ACSS2 mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ACSS2 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of ACSS2 mRNA18042831|2260994
D004041Dietary FatsDietary Fats results in decreased expression of ACSS2 protein28077572
D004041Dietary FatsFGF15 gene mutant form inhibits the reaction [Dietary Fats results in decreased expression of ACSS2 mRNA]28673684
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ACSS2 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ACSS2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ACSS2 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSS2 mRNA"28433925
D004147DioxinsDioxins affects the expression of ACSS2 mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ACSS2 mRNA24690739
D004237DiuronDiuron results in decreased expression of ACSS2 mRNA21551480|2417259
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ACSS2 mRNA25064622
C024565ethylene dichlorideethylene dichloride results in decreased expression of ACSS2 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of ACSS2 mRNA25572481
C000499ferric oxideferric oxide analog results in increased expression of ACSS2 mRNA25086211
D005839GentamicinsGentamicins results in increased expression of ACSS2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ACSS2 mRNA24136188
D005944GlucosamineGlucosamine results in increased expression of ACSS2 mRNA17178593
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ACSS2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ACSS2 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ACSS2 mRNA27392435
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ACSS2 mRNA27339419
D008727MethotrexateMethotrexate results in increased expression of ACSS2 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ACSS2 mRNA23103053
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ACSS2 mRNA"20188158
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ACSS2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACSS2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACSS2 mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of ACSS2 mRNA24136188
D009532NickelNickel results in decreased expression of ACSS2 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of ACSS2 mRNA22714537
C025589ochratoxin Aochratoxin A results in decreased expression of ACSS2 mRNA19717638
D010100OxygenOxygen deficiency results in increased expression of ACSS2 mRNA24236059
D000073878Palm OilPalm Oil affects the expression of ACSS2 mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of ACSS2 mRNA18042831
D010269ParaquatParaquat affects the expression of ACSS2 mRNA25064622
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of ACSS2 mRNA21705711
C006253pirinixic acidpirinixic acid results in decreased expression of ACSS2 mRNA18445702
D011192Potassium DichromatePotassium Dichromate results in increased expression of ACSS2 protein23718831
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ACSS2 mRNA28903501
D011374ProgesteroneProgesterone results in increased expression of ACSS2 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in decreased expression of ACSS2 mRNA24780913
C502851quinocetonequinocetone results in increased expression of ACSS2 mRNA27046791
D019438RitonavirRitonavir affects the expression of ACSS2 mRNA17719200
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of ACSS2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ACSS2 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of ACSS2 mRNA25993096
C013698tallowtallow affects the expression of ACSS2 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of ACSS2 mRNA20937368
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate promotes the reaction [LEP gene mutant form results in decreased expression of ACSS2 mRNA]21079772
D013739TestosteroneTestosterone results in increased expression of ACSS2 mRNA16579987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSS2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACSS2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSS2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSS2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSS2 mRNA21215274|2172422
D013752TetracyclineTetracycline affects the expression of ACSS2 mRNA25064622
D013752TetracyclineTetracycline results in decreased expression of ACSS2 mRNA24489787
D013853ThioacetamideThioacetamide affects the expression of ACSS2 mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of ACSS2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACSS2 mRNA28065790
C066340tolcaponetolcapone results in increased expression of ACSS2 mRNA24136188
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ACSS2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ACSS2 mRNA25572481
D014520UrethaneUrethane results in decreased expression of ACSS2 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ACSS2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of ACSS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ACSS2 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of ACSS2 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ACSS2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of ACSS2 mRNA21427059|2453556
D014640VancomycinVancomycin results in increased expression of ACSS2 mRNA18930951
D014752Vinyl ChlorideVinyl Chloride results in increased expression of ACSS2 mRNA18579281
D014801Vitamin AVitamin A deficiency results in decreased expression of ACSS2 mRNA12163651
D015032ZincZinc deficiency results in increased expression of ACSS2 mRNA20932299
C088658zoledronic acidzoledronic acid results in increased expression of ACSS2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003987acetate-CoA ligase activity-IDA10843999  
GO:0003987acetate-CoA ligase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0016208AMP binding-IC10843999  
GO ID GO Term Qualifier Evidence PubMed
GO:0006069ethanol oxidation-TAS-  
GO:0008610lipid biosynthetic process-IMP10843999  
GO:0019413acetate biosynthetic process-IEA-  
GO:0019427acetyl-CoA biosynthetic process from acetate-IEA-  
GO:0019542propionate biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IC10843999  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28550509Possible involvement of ACSS2 gene in alcoholism. (2017 Sep)Ribeiro AFJ Neural Transm (Vienna)