Gene: ANGPTL8

55908
C19orf80|PRO1185|PVPA599|RIFL|TD26
angiopoietin like 8
protein-coding
19p13.2
Ensembl:ENSG00000130173 MIM:616223 Vega:OTTHUMG00000180829 UniprotKB:Q6UXH0
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.941e-1 (AD)  8.701e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ANGPTL8 mRNA21632981|2164198
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANGPTL8 mRNA21632981|2623829
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ANGPTL8 mRNA27339419
D019327Copper SulfateCopper Sulfate results in increased expression of ANGPTL8 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of ANGPTL8 mRNA21632981|2556210
D004041Dietary FatsDietary Fats results in increased expression of ANGPTL8 mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ANGPTL8 mRNA21527772
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ANGPTL8 mRNA24535843
D019833GenisteinGenistein results in decreased methylation of ANGPTL8 gene28505145
C046012pentanalpentanal results in increased expression of ANGPTL8 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of ANGPTL8 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of ANGPTL8 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ANGPTL8 mRNA21632981
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ANGPTL8 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ANGPTL8 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of ANGPTL8 mRNA28973697
D014520UrethaneUrethane results in decreased expression of ANGPTL8 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of ANGPTL8 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21988832  
GO ID GO Term Qualifier Evidence PubMed
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010954positive regulation of protein processing-IDA23150577  
GO:0019216regulation of lipid metabolic process-IBA21873635  
GO:0019216regulation of lipid metabolic process-IDA25417115  
GO:0044255cellular lipid metabolic process-ISS-  
GO:0044342type B pancreatic cell proliferationNOTIDA25417115  
GO:0045444fat cell differentiation-IEA-  
GO:0048469cell maturation-IEA-  
GO:0050746regulation of lipoprotein metabolic process-IMP23150577  
GO:0051004regulation of lipoprotein lipase activity-TAS-  
GO:0070328triglyceride homeostasis-IBA21873635  
GO:0070328triglyceride homeostasis-IDA25417115  
GO:0070328triglyceride homeostasis-IGI23150577  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IBA21873635  
GO:0005576extracellular region-IDA23150577  
GO:0005576extracellular region-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8963889Assembly of active LPL and LIPC lipase complexesTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29538435Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study. (2018)Morinaga JPLoS One