Gene: PRKG1

5592
AAT8|PKG|PKG1|PRKG1B|PRKGR1B|cGK|cGK 1|cGK1|cGKI|cGKI-BETA|cGKI-alpha
protein kinase cGMP-dependent 1
protein-coding
10q11.23-q21.1
Ensembl:ENSG00000185532 MIM:176894 Vega:OTTHUMG00000018248 UniprotKB:Q13976
NG_029982.1
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.148e-1 (AD)  7.915e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1729578chr10:52223498 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17641137chr10:52046842 (GRCh38.p7)C>Talcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)
rs7080306chr10:51854153 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1937701chr10:51849217 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10490975chr10:51261176 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04004590chr10:52750296PRKG1Promoter6.544e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDLIM50.728
TMEM470.724
ZBTB100.699
FBXO80.697
MTM10.697
CPNE30.696
FGD40.694
TOR1AIP10.689
MSRB30.688
ANTXR10.684

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LAMB3-0.372
NKD2-0.362
EGR4-0.342
RHO-0.321
GPR68-0.32
TNFRSF18-0.318
OR4F5-0.308
KCNG2-0.305
ABCC12-0.299
GALNTL5-0.299

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]"15617736
C4590922-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine"2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]"23195829
C4590922-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine"[calyculin A co-treated with Okadaic Acid] inhibits the reaction [2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]]"23195829
C0909373-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole results in increased expression of PRKG1 protein11602670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKG1 mRNA"27188386
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride results in increased expression of PRKG1 protein11602670
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKG1 mRNA"27188386
C0801227-nitroindazole7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]15617736
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] promotes the reaction [ARHGEF17 protein results in increased activity of RHOA protein]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[calyculin A co-treated with Okadaic Acid] inhibits the reaction [2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]"23195829
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]"11799084
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in decreased expression of PRKG1 protein"9366573
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in decreased expression of PRKG1 protein alternative form"11799084
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased activity of PRKG1 protein"11799084
C0908608-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate"PRKG1 protein affects the reaction [8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate results in decreased expression of IL4 protein]"16533816
C0908608-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate"8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate binds to and results in decreased activity of PRKG1 protein"19542178
C0162768-bromocyclic GMP[8-bromocyclic GMP co-treated with PRKG1 protein co-treated with ARHGEF17 protein] results in increased activity of SRF protein23195829
C0162768-bromocyclic GMP8-bromocyclic GMP results in increased activity of PRKG1 protein17616649
C0162768-bromocyclic GMPAcetylcysteine inhibits the reaction [Oxygen deficiency inhibits the reaction [8-bromocyclic GMP results in increased activity of PRKG1 protein]]17616649
C0162768-bromocyclic GMPOxygen deficiency inhibits the reaction [8-bromocyclic GMP results in increased activity of PRKG1 protein]17616649
C0162768-bromocyclic GMP8-bromocyclic GMP results in increased expression of PRKG1 protein12620371
C0162768-bromocyclic GMP8-bromocyclic GMP results in increased activity of PRKG1 protein12620371|1935937
C0837638-bromoguanosino-3',5'-cyclic monophosphorothioate"8-bromoguanosino-3',5'-cyclic monophosphorothioate inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein]"12620371
C0837638-bromoguanosino-3',5'-cyclic monophosphorothioate"8-bromoguanosino-3',5'-cyclic monophosphorothioate analog results in decreased activity of PRKG1 protein"12620371
C0837638-bromoguanosino-3',5'-cyclic monophosphorothioate"8-bromoguanosino-3',5'-cyclic monophosphorothioate results in decreased activity of PRKG1 protein"12620371
C056165acetovanilloneacetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Oxygen deficiency inhibits the reaction [8-bromocyclic GMP results in increased activity of PRKG1 protein]]17616649
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Oxygen deficiency results in decreased expression of PRKG1 protein]17616649
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PRKG1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PRKG1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PRKG1 mRNA21298039
D000641AmmoniaPRKG1 protein affects the susceptibility to Ammonia19393034
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKG1 mRNA15894712
C015001arsenitearsenite results in decreased expression of PRKG1 mRNA15894712
D001280AtrazineAtrazine results in decreased expression of PRKG1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRKG1 mRNA22316170
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of PRKG1 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRKG1 mRNA15894712
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKG1 mRNA"20382639
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PRKG1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PRKG1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PRKG1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PRKG1 gene28505145
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRKG1 mRNA28628672
D002118CalciumPRKG1 protein results in increased susceptibility to Calcium16533816
C059041calyculin A"[calyculin A co-treated with Okadaic Acid] inhibits the reaction [2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]]"23195829
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PRKG1 mRNA17484886
D003300Copper[Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein26168186
D003300CopperVIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]26168186
D016572CyclosporineCyclosporine results in increased expression of PRKG1 mRNA16378109
D016572CyclosporineCyclosporine results in increased expression of PRKG1 protein16378109
D016572CyclosporinePhenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]16378109
D016572CyclosporinePhenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]16378109
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PRKG1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRKG1 mRNA28628672
D003994BucladesineBucladesine results in decreased expression of PRKG1 mRNA9366573
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PRKG1 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of PRKG1 mRNA18042831
C058705diethyl malatediethyl malate affects the expression of PRKG1 mRNA24814887
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of PRKG1 mRNA26924002
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D004610Ellagic AcidEllagic Acid results in decreased expression of PRKG1 mRNA12002526
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRKG1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PRKG1 mRNA17942748
D005473FluoxetineFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein]21619414
D005557Formaldehyde"8-bromoguanosino-3',5'-cyclic monophosphorothioate inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein]"12620371
D005557FormaldehydeFormaldehyde results in increased expression of PRKG1 protein12620371
D005557FormaldehydeMorphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein]12620371
C069837fullerene C60fullerene C60 results in decreased expression of PRKG1 mRNA19167457
C001277geldanamycingeldanamycin results in increased expression of PRKG1 mRNA26705709
D005947Glucoseacetovanillone inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D005947Glucosediphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D005947GlucoseGlucose results in decreased expression of and results in decreased activity of PRKG1 protein17320767
D005947GlucoseGlucose results in decreased expression of PRKG1 mRNA17320767
D005947Glucosemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D005947GlucoseReactive Oxygen Species promotes the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D005947Glucosetempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D006152Cyclic GMPCyclic GMP results in increased activity of PRKG1 protein17616649
D006152Cyclic GMPPeroxynitrous Acid inhibits the reaction [Cyclic GMP results in increased activity of PRKG1 protein]17616649
D006152Cyclic GMPCyclic GMP results in increased activity of PRKG1 protein18037907
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PRKG1 mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PRKG1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRKG1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PRKG1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRKG1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PRKG1 mRNA28628672
D007548Isosorbide DinitrateIsosorbide Dinitrate results in decreased expression of PRKG1 protein9366573
C439304KMUP 1KMUP 1 results in increased expression of PRKG1 protein19962417
C073601KT 5823"KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein]"23195829
C073601KT 5823"KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]"23195829
C031895lead chromatelead chromate results in decreased expression of PRKG1 mRNA23584427
C002385linsidominelinsidomine results in decreased activity of PRKG1 protein alternative form21351102
C002385linsidominelinsidomine results in increased metabolism of PRKG1 protein alternative form21351102
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D008694MethamphetaminePRKG1 gene SNP affects the susceptibility to Methamphetamine18316681
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PRKG1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PRKG1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PRKG1 mRNA24810058
D008799Mevinphos"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]"15617736
D008799Mevinphos7-nitroindazole inhibits the reaction [Mevinphos results in increased expression of PRKG1 protein]15617736
D008799MevinphosMevinphos results in increased expression of PRKG1 protein15617736
D016686MonocrotalineFluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein]21619414
D016686MonocrotalineMonocrotaline results in decreased expression of PRKG1 protein21619414
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PRKG1 mRNA26924002
D009020MorphineMorphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein]12620371
D009532NickelNickel results in decreased expression of PRKG1 mRNA24768652|2558310
D005996NitroglycerinNitroglycerin results in decreased expression of PRKG1 protein11331261
D005996NitroglycerinNitroglycerin results in decreased expression of PRKG1 protein11331261
D005996NitroglycerinNitroglycerin affects the expression of PRKG1 mRNA18037907
D005996NitroglycerinNitroglycerin affects the expression of PRKG1 protein18037907
D005996NitroglycerinNitroglycerin results in increased activity of PRKG1 protein18037907
D005996NitroglycerinSuperoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]18037907
D009599NitroprussideNitroprusside results in decreased expression of PRKG1 mRNA9366573
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased expression of PRKG1 mRNA9366573
D026423S-Nitroso-N-Acetylpenicillamine[S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]11799084
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein11799084
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PRKG1 mRNA27935865
C093285NOC 18PRKG1 protein promotes the reaction [NOC 18 results in increased expression of COL4A2 protein]21307347
C093285NOC 18PRKG1 protein promotes the reaction [NOC 18 results in increased expression of COL4A3 mRNA]21307347
D019319Okadaic Acid"[calyculin A co-treated with Okadaic Acid] inhibits the reaction [2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]]"23195829
D010100OxygenAcetylcysteine inhibits the reaction [Oxygen deficiency inhibits the reaction [8-bromocyclic GMP results in increased activity of PRKG1 protein]]17616649
D010100OxygenAcetylcysteine inhibits the reaction [Oxygen deficiency results in decreased expression of PRKG1 protein]17616649
D010100OxygenOxygen deficiency inhibits the reaction [8-bromocyclic GMP results in increased activity of PRKG1 protein]17616649
D010100OxygenOxygen deficiency inhibits the reaction [Oxygen inhibits the reaction [Oxygen deficiency results in decreased expression of PRKG1 protein]]17616649
D010100OxygenOxygen deficiency results in decreased expression of PRKG1 protein17616649
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in decreased expression of PRKG1 protein]17616649
D000073878Palm OilPalm Oil results in increased expression of PRKG1 mRNA18042831
D030421Peroxynitrous AcidPeroxynitrous Acid inhibits the reaction [Cyclic GMP results in increased activity of PRKG1 protein]17616649
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of PRKG1 protein17616649
D010656Phenylephrine"[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]"11799084
D010656PhenylephrineFLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]19542178
D010656PhenylephrinePDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein]19797176
D010656Phenylephrine[Phenylephrine co-treated with Copper] results in increased activity of PRKG1 protein26168186
D010656PhenylephrinePhenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 mRNA]16378109
D010656PhenylephrinePhenylephrine inhibits the reaction [Cyclosporine results in increased expression of PRKG1 protein]16378109
D010656PhenylephrinePhenylephrine results in decreased activity of PRKG1 protein19797176
D010656PhenylephrinePhenylephrine results in increased activity of PRKG1 protein19542178|2616818
D010656PhenylephrinePhenylephrine results in increased expression of PRKG1 protein26168186
D010656Phenylephrine[S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]11799084
D010656PhenylephrineVIM mutant form inhibits the reaction [[Copper co-treated with Phenylephrine] results in increased activity of PRKG1 protein]26168186
D010656PhenylephrineVIM mutant form inhibits the reaction [Phenylephrine results in increased activity of PRKG1 protein]26168186
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PRKG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PRKG1 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PRKG1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKG1 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PRKG1 mRNA21334430
D017382Reactive Oxygen SpeciesReactive Oxygen Species promotes the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
D000068677Sildenafil CitratePRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of COL1A1 mRNA]]25139994
D000068677Sildenafil CitratePRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of CTGF mRNA]]25139994
D000068677Sildenafil CitratePRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of FN1 mRNA]]25139994
D000068677Sildenafil CitratePRKG1 protein promotes the reaction [Sildenafil Citrate inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 mRNA]]25139994
D000068677Sildenafil CitratePRKG1 protein results in increased susceptibility to Sildenafil Citrate25139994
D012822Silicon DioxideSilicon Dioxide analog affects the expression of PRKG1 mRNA23806026
C009277sodium arsenatesodium arsenate results in increased expression of PRKG1 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of PRKG1 protein27774770
D012969Sodium FluorideSodium Fluoride results in increased expression of PRKG1 protein28918527
C091861spermine nitric oxide complexPRKG1 protein affects the reaction [spermine nitric oxide complex results in increased expression of IL4 protein]16533816
C091861spermine nitric oxide complexspermine nitric oxide complex results in decreased activity of PRKG1 protein alternative form21351102
C091861spermine nitric oxide complexspermine nitric oxide complex results in increased metabolism of PRKG1 protein alternative form21351102
C091861spermine nitric oxide complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [spermine nitric oxide complex results in decreased activity of PRKG1 protein alternative form]21351102
C091861spermine nitric oxide complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [spermine nitric oxide complex results in increased metabolism of PRKG1 protein alternative form]21351102
D013395SucroseSucrose results in decreased expression of PRKG1 protein17215582
C025463sulindac sulfonesulindac sulfone results in increased expression of PRKG1 protein11602670|1673175
D013481SuperoxidesSuperoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]18037907
D013629TamoxifenTamoxifen affects the expression of PRKG1 mRNA17555576
C001803tempoltempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein]17320767
C004648testosterone enanthatetestosterone enanthate affects the expression of PRKG1 mRNA17440010
C004648testosterone enanthatetestosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]20463352
C004648testosterone enanthatetestosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]20463352
C004648testosterone enanthatetestosterone enanthate results in decreased expression of PRKG1 mRNA20463352|2308548
C004648testosterone enanthatetestosterone enanthate results in decreased expression of PRKG1 protein20463352
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKG1 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKG1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRKG1 mRNA20159946
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [spermine nitric oxide complex results in decreased activity of PRKG1 protein alternative form]21351102
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [spermine nitric oxide complex results in increased metabolism of PRKG1 protein alternative form]21351102
D013792ThalidomideThalidomide results in decreased expression of PRKG1 mRNA26217789
C012589trichostatin Atrichostatin A results in increased expression of PRKG1 mRNA27188386
D017329Triptorelin Pamoatetestosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]20463352
D017329Triptorelin Pamoatetestosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]20463352
D017329Triptorelin PamoateTriptorelin Pamoate results in decreased expression of PRKG1 mRNA20463352
D017329Triptorelin PamoateTriptorelin Pamoate results in decreased expression of PRKG1 protein20463352
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PRKG1 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of PRKG1 mRNA23179753|2718838
D014639VanadiumVanadium results in decreased expression of PRKG1 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRKG1 gene25560391
C111237vorinostatvorinostat results in increased expression of PRKG1 mRNA27188386
C108830Y 27632"Y 27632 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of ARHGEF17 protein]"23195829

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IMP25447536  
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004692cGMP-dependent protein kinase activity-IDA21402151  
GO:0004692cGMP-dependent protein kinase activity-TAS-  
GO:0005246calcium channel regulator activity-IDA21402151  
GO:0005515protein binding-IPI10671526  16990611  18757735  19424179  21402151  25416956  
GO:0005524ATP binding-IEA-  
GO:0030553cGMP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IEA-  
GO:0006468protein phosphorylationNOTIDA15905169  
GO:0007165signal transduction-TAS2792381  
GO:0016358dendrite development-IEA-  
GO:0019934cGMP-mediated signaling-IEA-  
GO:0030036actin cytoskeleton organization-TAS10851246  
GO:0030900forebrain development-IEA-  
GO:0043087regulation of GTPase activity-IMP14608379  
GO:0060087relaxation of vascular smooth muscle-IEA-  
GO:0090331negative regulation of platelet aggregation-IMP16990611  
GO:1904706negative regulation of vascular smooth muscle cell proliferation-IDA25447536  
GO:1904753negative regulation of vascular associated smooth muscle cell migration-IDA25447536  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA21402151  
GO:0005794Golgi apparatus-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA21402151  
KEGG ID KEGG Term
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04730Long-term depression
hsa04740Olfactory transduction
hsa04970Salivary secretion
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-109582HemostasisTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionIEA
R-HSA-168256Immune SystemTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-392154Nitric oxide stimulates guanylate cyclaseIEA
R-HSA-392154Nitric oxide stimulates guanylate cyclaseTAS
R-HSA-392517Rap1 signallingTAS
R-HSA-4086398Ca2+ pathwayIEA
R-HSA-418346Platelet homeostasisIEA
R-HSA-418346Platelet homeostasisTAS
R-HSA-418457cGMP effectsIEA
R-HSA-418457cGMP effectsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal