Gene: DMAP1

55929
DNMAP1|DNMTAP1|EAF2|MEAF2|SWC4
DNA methyltransferase 1 associated protein 1
protein-coding
1p34.1
Ensembl:ENSG00000178028 MIM:605077 Vega:OTTHUMG00000007577 UniprotKB:Q9NPF5
NC_000001.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.518e-1 (AD)  3.098e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SUGP10.945
ARFGAP10.941
CCDC220.938
ATG4B0.933
CCAR20.931
NCAPH20.93
HECTD30.93
NCLN0.929
EDC40.929
DDX510.929

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.685
OR4F29-0.637
MTRNR2L9-0.327
MTRNR2L6-0.311
TFPI2-0.308
MTRNR2L10-0.303
KCNJ15-0.292
CXCR2-0.288
FCGR3B-0.288
C9orf153-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DMAP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DMAP1 mRNA"21346803
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of DMAP1 mRNA"19446018
D001280AtrazineAtrazine results in decreased expression of DMAP1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DMAP1 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of DMAP1 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DMAP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of DMAP1 mRNA25181051
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DMAP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of DMAP1 mRNA17361019
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of DMAP1 mRNA24834073
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DMAP1 mRNA22079256
D018120FinasterideFinasteride results in increased expression of DMAP1 mRNA24136188
D005485FlutamideFlutamide results in increased expression of DMAP1 mRNA24136188
C039281furanfuran results in increased methylation of DMAP1 gene22079235
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DMAP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DMAP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of DMAP1 mRNA28628672
C544151jinfukangjinfukang results in increased expression of DMAP1 mRNA27392435
D007657Ketone BodiesKetone Bodies results in increased expression of DMAP1 mRNA16807920
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DMAP1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of DMAP1 mRNA26011545
D008777MethyltestosteroneMethyltestosterone results in decreased expression of DMAP1 mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of DMAP1 mRNA26924002
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DMAP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DMAP1 mRNA22079256
D012715Sesame OilSesame Oil results in increased expression of DMAP1 mRNA29191790
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DMAP1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DMAP1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DMAP1 mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DMAP1 mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of DMAP1 mRNA28973697
D001335Vehicle EmissionsVehicle Emissions affects the methylation of DMAP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0001103RNA polymerase II repressing transcription factor binding-IDA15367675  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0005515protein binding-IPI15367675  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA15367675  
GO:0006281DNA repair-IEA-  
GO:0006306DNA methylation-TAS10888872  
GO:0006338chromatin remodeling-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0040008regulation of growth-IEA-  
GO:0042307positive regulation of protein import into nucleus-IDA15367675  
GO:0043967histone H4 acetylation-IBA21873635  
GO:0043967histone H4 acetylation-IDA14966270  
GO:0043968histone H2A acetylation-IBA21873635  
GO:0043968histone H2A acetylation-IDA14966270  
GO:0045471response to ethanol-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-NAS10888872  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA15367675  
GO:0005634nucleus-NAS10888872  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IEA-  
GO:0005737cytoplasm-IDA15367675  
GO:0005829cytosol-IDA-  
GO:0035267NuA4 histone acetyltransferase complex-IBA21873635  
GO:0035267NuA4 histone acetyltransferase complex-IDA14966270  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214847HATs acetylate histonesIEA
R-HSA-3247509Chromatin modifying enzymesIEA
R-HSA-4839726Chromatin organizationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24527678Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. (2014 Jun)Echeverry-Alzate VBr J Pharmacol