Gene: PRKG2

5593
PKG2|PRKGR2|cGK2|cGKII
protein kinase cGMP-dependent 2
protein-coding
4q21.21
Ensembl:ENSG00000138669 MIM:601591 Vega:OTTHUMG00000130296 UniprotKB:Q13237
NC_000004.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.262e-3 (AD)  3.675e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16744741chr4:82126025PRKG24.700e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS6ST30.848
SHC30.822
KIAA12110.813
RGS7BP0.811
PITPNB0.802
GPR260.798
TFDP20.796
GRM50.796
TRIQK0.793
SSTR10.79

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROM1-0.468
BCL7C-0.453
APOM-0.453
SNHG18-0.449
GNG8-0.425
RAB13-0.413
C11orf88-0.412
KIF19-0.403
NRN1L-0.403
C19orf18-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PRKG2 mRNA"28903501
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PRKG2 mRNA19933214
C0556568-((4-chlorophenyl)thio)cyclic-3',5'-GMP"8-((4-chlorophenyl)thio)cyclic-3',5'-GMP results in increased activity of PRKG2 protein"19359370
C0908608-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate"8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate results in decreased activity of PRKG2 protein"19359370
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRKG2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PRKG2 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of PRKG2 mRNA"25351596
D001280AtrazineAtrazine results in decreased expression of PRKG2 mRNA25929836
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKG2 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of PRKG2 mRNA27685785
C006780bisphenol Abisphenol A affects the methylation of PRKG2 promoter27415467
C006780bisphenol Abisphenol A results in decreased expression of PRKG2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PRKG2 promoter22457795
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PRKG2 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of PRKG2 mRNA17585979
D060729Coal AshCoal Ash results in increased expression of PRKG2 mRNA19000753
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of PRKG2 mRNA15467011
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRKG2 mRNA24317228
D003907DexamethasoneDexamethasone promotes the reaction [Lipopolysaccharides results in decreased expression of PRKG2 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of PRKG2 mRNA22185406|2273378
D002945CisplatinCisplatin results in increased expression of PRKG2 mRNA27392435
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of PRKG2 mRNA28085963
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of PRKG2 promoter27415467
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRKG2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKG2 mRNA17942748
D005947GlucoseGlucose results in increased expression of PRKG2 mRNA17178593
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of PRKG2 mRNA15618438
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRKG2 mRNA26752646
D007854LeadLead affects the expression of PRKG2 mRNA28903495
D008070LipopolysaccharidesDexamethasone promotes the reaction [Lipopolysaccharides results in decreased expression of PRKG2 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PRKG2 mRNA22185406
D008774MethylphenidateMethylphenidate results in increased expression of PRKG2 mRNA22470460
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PRKG2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRKG2 mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PRKG2 mRNA17616710
C010272palytoxinpalytoxin results in increased expression of PRKG2 mRNA26436198
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PRKG2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PRKG2 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of PRKG2 mRNA17426115
D011192Potassium DichromatePotassium Dichromate results in increased expression of PRKG2 mRNA11678601
D011441PropylthiouracilPropylthiouracil results in increased expression of PRKG2 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PRKG2 mRNA25351596
D013311Streptozocin[ALPK1 protein results in increased susceptibility to Streptozocin] which results in decreased expression of PRKG2 mRNA27542954
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of PRKG2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRKG2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRKG2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRKG2 mRNA19933214
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PRKG2 mRNA20133372
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PRKG2 mRNA19042947
D014527Uric AcidUric Acid results in decreased expression of PRKG2 mRNA27542954
D014635Valproic AcidValproic Acid affects the expression of PRKG2 mRNA25979313
D014639VanadiumVanadium results in decreased expression of PRKG2 mRNA19000753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PRKG2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of PRKG2 mRNA25423262
C029297vinylidene chloridevinylidene chloride results in increased expression of PRKG2 mRNA26682919
D015032ZincZinc deficiency results in increased expression of PRKG2 mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS8607838  
GO:0004692cGMP-dependent protein kinase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0030553cGMP binding-IEA-  
GO:0042803protein homodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IMP15905169  
GO:0007165signal transduction-TAS8607838  
GO:0036289peptidyl-serine autophosphorylation-IEA-  
GO:0051186cofactor metabolic process-TAS-  
GO:0072659protein localization to plasma membrane-IEA-  
GO:2001226negative regulation of chloride transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016324apical plasma membrane-IEA-  
GO:0031965nuclear membrane-IEA-  
KEGG ID KEGG Term
hsa04540Gap junction
hsa04730Long-term depression
hsa04740Olfactory transduction
hsa04970Salivary secretion
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-109582HemostasisTAS
R-HSA-1430728MetabolismTAS
R-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationTAS
R-HSA-162582Signal TransductionIEA
R-HSA-195721Signaling by WNTIEA
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-3858494Beta-catenin independent WNT signalingIEA
R-HSA-392154Nitric oxide stimulates guanylate cyclaseIEA
R-HSA-392154Nitric oxide stimulates guanylate cyclaseTAS
R-HSA-4086398Ca2+ pathwayIEA
R-HSA-418346Platelet homeostasisIEA
R-HSA-418346Platelet homeostasisTAS
R-HSA-418457cGMP effectsIEA
R-HSA-418457cGMP effectsTAS
R-HSA-8978934Metabolism of cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18606955Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. (2008 Jul)Schumann GArch Gen Psychiatry