Gene: APOM

55937
G3a|HSPC336|NG20|apo-M
apolipoprotein M
protein-coding
6p21.33
Ensembl:ENSG00000204444 MIM:606907 Vega:OTTHUMG00000031250 UniprotKB:O95445
NC_000006.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A130.772
TRIP60.754
PRTFDC10.739
CRYL10.733
RAB340.725
TST0.721
HSD17B80.72
DECR10.716
EFEMP20.711
PHYHD10.711

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPRD1-0.572
KCNH1-0.558
HRH2-0.551
FAM78B-0.547
HS6ST3-0.544
GPR26-0.538
C4orf50-0.534
KIAA1549-0.532
KCNH5-0.53
KLHL29-0.53

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08231Myristic acidSmall Molecule544-63-8ExperimentalCarrier
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of APOM mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of APOM mRNA"28433925
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of APOM mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of APOM mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOM mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOM mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOM mRNA"27188386
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of APOM mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of APOM mRNA]17585979
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of APOM mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APOM mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of APOM mRNA"22863853
D001104ArbutinArbutin results in increased expression of APOM mRNA17103032
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in decreased expression of APOM mRNA17639512
D001280AtrazineAtrazine results in decreased expression of APOM mRNA27413107
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOM mRNA18164116
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of APOM mRNA17404688
C006780bisphenol Abisphenol A results in increased expression of APOM mRNA26364221
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of APOM mRNA"28433925
C032036bromobenzenebromobenzene results in increased expression of APOM mRNA12628495
D002110CaffeineCaffeine results in decreased expression of APOM mRNA25868845
D002118CalciumCalcium affects the expression of APOM mRNA15913539
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of APOM mRNA27174168
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of APOM mRNA16197558
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of APOM mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of APOM mRNA17585979|2527062
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of APOM mRNA]17585979
D003300CopperCopper results in decreased expression of APOM mRNA20875833
D019327Copper SulfateCopper Sulfate results in decreased expression of APOM mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of APOM mRNA17211630
D003471CuprizoneCuprizone results in increased expression of APOM mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of APOM mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of APOM mRNA24834073
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APOM mRNA]27941970
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of APOM mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of APOM mRNA15238619
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of APOM mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of APOM mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of APOM mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOM mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOM mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of APOM mRNA19638242
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of APOM mRNA24834073
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOM mRNA17942748
D005485FlutamideFlutamide results in decreased expression of APOM mRNA24136188
D005485FlutamideFlutamide results in increased expression of APOM mRNA24793618
C039281furanfuran results in decreased expression of APOM mRNA25539665|2619464
C039281furanfuran results in increased methylation of APOM gene22079235
C412815GW 4064GW 4064 results in increased expression of APOM mRNA26655953
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of APOM mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APOM mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of APOM mRNA18054359
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of APOM protein18054359
D008627Mercuric ChlorideMercuric Chloride results in increased expression of APOM mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of APOM mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of APOM mRNA27544571
C051752nefazodonenefazodone results in decreased expression of APOM mRNA24136188
C028007nickel monoxidenickel monoxide results in increased expression of APOM mRNA19167457
C016030pantogabpantogab results in decreased expression of APOM mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOM mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOM mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of APOM mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of APOM mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of APOM mRNA15375163|2081375
C006253pirinixic acidpirinixic acid results in decreased expression of APOM mRNA19162173
D011192Potassium DichromatePotassium Dichromate results in increased expression of APOM mRNA23608068
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of APOM mRNA17404688
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in decreased expression of APOM mRNA17639512
D011794QuercetinQuercetin results in decreased expression of APOM mRNA21632981
C059514resveratrolresveratrol results in decreased expression of APOM protein25505154
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of APOM mRNA25895662
D019821SimvastatinSimvastatin results in decreased expression of APOM mRNA21729290
D019821SimvastatinSimvastatin results in increased expression of APOM mRNA22160096
D019821SimvastatinSimvastatin results in increased expression of APOM protein22160096
D019821SimvastatinTO-901317 inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]22160096
D019821SimvastatinTO-901317 inhibits the reaction [Simvastatin results in increased expression of APOM protein]22160096
D019821SimvastatinUrsodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]22160096
D019821SimvastatinUrsodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein]22160096
D019821SimvastatinSimvastatin results in increased expression of APOM mRNA22160096
D019821SimvastatinSimvastatin results in increased expression of APOM protein22160096
C021751tanshinonetanshinone results in increased expression of APOM mRNA15849732
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APOM mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APOM mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of APOM mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOM mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOM mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APOM mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOM mRNA28943392
C423915TO-901317TO-901317 inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]22160096
C423915TO-901317TO-901317 inhibits the reaction [Simvastatin results in increased expression of APOM protein]22160096
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of APOM mRNA28065790
D014212TretinoinTretinoin results in decreased expression of APOM mRNA18230668
C012589trichostatin Atrichostatin A results in decreased expression of APOM mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of APOM mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of APOM mRNA29024780
D014425TurpentineTurpentine results in decreased expression of APOM mRNA18054359
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM mRNA]22160096
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Simvastatin results in increased expression of APOM protein]22160096
D014635Valproic AcidValproic Acid results in decreased expression of APOM mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APOM mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of APOM mRNA24935251|2627250
D014640VancomycinVancomycin results in increased expression of APOM mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of APOM gene25560391
C025643vinclozolinvinclozolin results in increased expression of APOM mRNA21126777
C029297vinylidene chloridevinylidene chloride results in decreased expression of APOM mRNA26682919
D014810Vitamin EVitamin E results in increased expression of APOM mRNA19244175
D015054ZymosanZymosan results in decreased expression of APOM mRNA18054359

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-IDA16682745  
GO:0005543phospholipid binding-IDA22204862  
GO:0016209antioxidant activity-IDA22204862  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0009749response to glucose-IEA-  
GO:0033344cholesterol efflux-IDA16682745  
GO:0033344cholesterol efflux-IMP15793583  
GO:0034375high-density lipoprotein particle remodeling-IMP18006500  
GO:0034380high-density lipoprotein particle assembly-ISS15793583  
GO:0034384high-density lipoprotein particle clearance-ISS15793583  
GO:0034445negative regulation of plasma lipoprotein oxidation-IDA16682745  22204862  
GO:0042157lipoprotein metabolic process-IEA-  
GO:0042632cholesterol homeostasis-IC15793583  
GO:0043691reverse cholesterol transport-ISS15793583  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0034361very-low-density lipoprotein particle-IDA17154273  
GO:0034362low-density lipoprotein particle-IDA16682745  
GO:0034364high-density lipoprotein particle-IDA22204862  
GO:0034365discoidal high-density lipoprotein particle-IDA15793583  
GO:0034366spherical high-density lipoprotein particle-IDA16682745  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17973931A genetic variant of apolipoprotein M increases susceptibility to coronary artery disease in a Chinese population. (2008 May)Xu WWClin Exp Pharmacol Physiol
28914078Evaluation of Expression Level of Apolipoprotein M as a Diagnostic Marker for Primary Venous Thromboembolism. (2018 Apr)Ahmad AClin Appl Thromb Hemost
24341666A single-nucleotide polymorphism in the proximal promoter region of the apolipoprotein M gene is associated with dyslipidaemia but not increased coronary artery diseases in Chinese populations. (2013 Dec 16)Cao BLipids Health Dis
20872094Association of apolipoprotein M gene polymorphisms with ischemic stroke in a Han Chinese population. (2011 Mar)Zhao DJ Mol Neurosci