Gene: NDUFA12

55967
B17.2|DAP13
NADH:ubiquinone oxidoreductase subunit A12
protein-coding
12q22
Ensembl:ENSG00000184752 MIM:614530 Vega:OTTHUMG00000170098 UniprotKB:Q9UI09
NG_032672.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.315e-2 (AD)  8.850e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11107851chr12:94995067 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs7133992chr12:94987926 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COX6C0.956
UQCRH0.955
COX7A20.952
COX6B10.949
MRPS210.948
NDUFA80.947
ATP6V1F0.946
COPS60.945
NDUFS50.945
PRDX50.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.833
OR4F29-0.802
SLC26A5-0.209
CXCR2-0.206
KCNJ15-0.198
VNN3-0.197
IL18RAP-0.196
C8orf74-0.196
CXCR1-0.19
OR6C74-0.187

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00157NADHSmall Molecule58-68-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C006632arsenic trioxidearsenic trioxide results in decreased expression of NDUFA12 protein25419056
C006632arsenic trioxidearsenic trioxide results in decreased expression of NDUFA12 mRNA19422848
D001280AtrazineAtrazine results in increased expression of NDUFA12 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NDUFA12 mRNA22228805|2719552
C006780bisphenol Abisphenol A results in increased expression of NDUFA12 mRNA28159858
C006780bisphenol Abisphenol A results in decreased expression of NDUFA12 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of NDUFA12 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of NDUFA12 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of NDUFA12 mRNA18804290
C100187chloropicrinchloropicrin affects the expression of NDUFA12 mRNA26352163
D003300CopperCopper results in decreased expression of NDUFA12 mRNA18522721
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NDUFA12 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NDUFA12 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NDUFA12 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of NDUFA12 mRNA28385952
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NDUFA12 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of NDUFA12 mRNA]17942915
D005485FlutamideFlutamide results in increased expression of NDUFA12 mRNA24136188
C039281furanfuran results in increased methylation of NDUFA12 gene22079235
C546771gardiquimodgardiquimod results in decreased expression of NDUFA12 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of NDUFA12 mRNA]28003376
D007213IndomethacinIndomethacin results in increased expression of NDUFA12 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NDUFA12 mRNA25613284
D007538IsoniazidIsoniazid affects the expression of NDUFA12 mRNA24848797
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NDUFA12 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of NDUFA12 mRNA"25554681
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of NDUFA12 mRNA]"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of NDUFA12 mRNA"21673326
D052638Particulate MatterParticulate Matter results in increased expression of NDUFA12 mRNA24769257
D010416PentachlorophenolPentachlorophenol results in decreased expression of NDUFA12 mRNA24642059
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of NDUFA12 mRNA20936131
C076994perfluorooctane sulfonic acidPPARA protein inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of NDUFA12 mRNA]20936131
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of NDUFA12 protein26879310
D010578PetroleumPetroleum affects the expression of NDUFA12 mRNA25208076
D010695PhlorhizinPhlorhizin results in increased expression of NDUFA12 mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of NDUFA12 mRNA23811191
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of NDUFA12 mRNA]28003376
D012402RotenoneRotenone results in increased expression of NDUFA12 mRNA17702527
D012402RotenoneRotenone results in increased expression of NDUFA12 mRNA19013527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NDUFA12 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NDUFA12 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NDUFA12 mRNA20399798
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NDUFA12 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of NDUFA12 mRNA22378314
D014050TolueneToluene affects the expression of NDUFA12 mRNA21827849
D014415TunicamycinTunicamycin results in decreased expression of NDUFA12 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of NDUFA12 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NDUFA12 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of NDUFA12 mRNA23555832
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of NDUFA12 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008137NADH dehydrogenase (ubiquinone) activity-NAS10830904  
GO:0009055electron transfer activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006979response to oxidative stress-IBA21873635  
GO:0006979response to oxidative stress-IDA12857734  
GO:0007585respiratory gaseous exchange-NAS10830904  
GO:0032981mitochondrial respiratory chain complex I assembly-TAS-  
GO:0042775mitochondrial ATP synthesis coupled electron transport-IMP24746669  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005747mitochondrial respiratory chain complex I-IBA21873635  
GO:0005747mitochondrial respiratory chain complex I-IDA12611891  27626371  
GO:0005747mitochondrial respiratory chain complex I-IMP24746669  
GO:0005829cytosol-IDA-  
GO:0030964NADH dehydrogenase complex-IBA21873635  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa05010Alzheimer's disease
hsa05012Parkinson's disease
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-163200Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.TAS
R-HSA-611105Respiratory electron transportTAS
R-HSA-6799198Complex I biogenesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal