Gene info: ID 55970

Gene: GNG12

GENE ID: 55970

Synonyms: -

Description: G protein subunit gamma 12

Gene type: protein-coding

Location: 1p31.3

dbXrefs: Ensembl:ENSG00000172380 MIM:615405 Vega:OTTHUMG00000009545 UniprotKB:Q9UBI6

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.661e-1 (AD) 9.427e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg25189904	chr1:68299493	GNG12		1.780e-25	Maternal smoking in pregnancy	27040690
cg26764244	chr1:68299511	GNG12		3.720e-22	Maternal smoking in pregnancy	27040690
cg13184736	chr1:68299409	GNG12		6.620e-8	Maternal smoking in pregnancy	27040690
cg25189904	chr1:68299493	GNG12		1.380e-32	Maternal smoking in pregnancy	27040690
cg26764244	chr1:68299511	GNG12		1.890e-24	Maternal smoking in pregnancy	27040690
cg13184736	chr1:68299409	GNG12		1.680e-9	Maternal smoking in pregnancy	27040690
cg25189904	chr1:68299493	GNG12		5.880e-34	Maternal smoking in pregnancy	27040690
cg26764244	chr1:68299511	GNG12		1.630e-28	Maternal smoking in pregnancy	27040690
cg13184736	chr1:68299409	GNG12		4.840e-10	Maternal smoking in pregnancy	27040690
cg26764244	chr1:68299511	GNG12		1.800e-28	Smoking	27651444
cg03140521	chr1:68299388	GNG12		2.800e-22	Smoking	27651444
cg25189904	chr1:68299493	GNG12		5.200e-22	Smoking	27651444
cg13184736	chr1:68299409	GNG12		4.300e-16	Smoking	27651444
cg13399816	chr1:68299468	GNG12		2.800e-15	Smoking	27651444
cg25189904	chr1:68299493	GNG12		1.230e-16	Tobacco smoking	28225026
cg26764244	chr1:68299511	GNG12		2.820e-8	Tobacco smoking	28225026
cg25189904	chr1:68299493	GNG12		4.720e-16	Smoking	28686328
cg26764244	chr1:68299511	GNG12		1.110e-8	Smoking	28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PDLIM5	0.906
CPNE3	0.904
MAML2	0.891
PLSCR4	0.888
PALLD	0.887
FERMT2	0.885
YAP1	0.884
PRKD3	0.883
EPS8	0.88
CNN3	0.873

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.651
CALHM1	-0.631
KCNB2	-0.607
ADTRP	-0.6
RHO	-0.59
CDCA5	-0.586
CACNA1F	-0.586
OVOL2	-0.582
ADRA1D	-0.581
GPR61	-0.579

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GNG12 mRNA"	19114083
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of GNG12 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG12 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG12 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of GNG12 mRNA	21420995\|2669055
D000082	Acetaminophen	Acetaminophen affects the expression of GNG12 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GNG12 protein	20106945
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GNG12 mRNA	16483693
D001564	Benzo(a)pyrene	AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of GNG12 mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GNG12 mRNA	15034205\|1977048
D004958	Estradiol	Estradiol results in increased expression of GNG12 mRNA	19484750
D004958	Estradiol	[bisphenol A co-treated with Estradiol] results in increased expression of GNG12 mRNA	26496021
C006780	bisphenol A	bisphenol A affects the methylation of GNG12 promoter	27334623
C006780	bisphenol A	[bisphenol A co-treated with Estradiol] results in increased expression of GNG12 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased expression of GNG12 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of GNG12 mRNA	22110744
D002220	Carbamazepine	Carbamazepine affects the expression of GNG12 mRNA	25979313
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GNG12 mRNA	17452286
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GNG12 mRNA	19320972
D003042	Cocaine	Cocaine affects the expression of GNG12 mRNA	20187946
D003471	Cuprizone	Cuprizone results in increased expression of GNG12 mRNA	27523638
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of GNG12 mRNA	17403535
D003976	Diazinon	Diazinon results in decreased expression of GNG12 mRNA	17452286
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GNG12 mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GNG12 mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of GNG12 mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of GNG12 mRNA	27392435
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GNG12 mRNA	25242112
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GNG12 mRNA"	19480007
D004147	Dioxins	Dioxins affects the expression of GNG12 mRNA	20463971
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GNG12 mRNA	17557909
C540355	fenamidone	fenamidone results in increased expression of GNG12 mRNA	27029645
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of GNG12 mRNA	16197558
D018120	Finasteride	Finasteride results in increased expression of GNG12 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of GNG12 mRNA	24136188
C001277	geldanamycin	geldanamycin results in increased expression of GNG12 mRNA	26705709
D017313	Fenretinide	Fenretinide results in increased expression of GNG12 mRNA	28973697
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of GNG12 mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of GNG12 mRNA	27392435
D007854	Lead	Lead affects the expression of GNG12 mRNA	28903495
C008261	lead acetate	lead acetate results in decreased expression of GNG12 mRNA	22613225
C045463	leflunomide	leflunomide results in increased expression of GNG12 mRNA	24136188
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GNG12 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of GNG12 mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in decreased expression of GNG12 mRNA	19167457
D011374	Progesterone	Progesterone affects the expression of GNG12 mRNA	17251523
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of GNG12 mRNA	24780913
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of GNG12 protein	28918527
D012999	Soman	Soman results in increased expression of GNG12 mRNA	19281266
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GNG12 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GNG12 mRNA	19770486
C009495	titanium dioxide	titanium dioxide results in increased expression of GNG12 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of GNG12 gene	26756918
C483909	torcetrapib	torcetrapib results in increased expression of GNG12 mRNA	23228038
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GNG12 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of GNG12 mRNA	24935251\|2627250
D014266	Trientine	Trientine results in increased expression of GNG12 protein	19634143
D017974	Uranium Compounds	Uranium Compounds results in decreased expression of GNG12 mRNA	19654044
D014635	Valproic Acid	Valproic Acid results in increased expression of GNG12 mRNA	19101580\|2718838
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of GNG12 gene	25560391
D014873	Water Pollutants	Water Pollutants results in decreased expression of GNG12 mRNA	23591932

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IEA	-
GO:0005515	protein binding	-	IPI	21988832 25416956
GO:0030165	PDZ domain binding	-	IBA	21873635
GO:0030165	PDZ domain binding	-	IDA	23209302
GO:0042301	phosphate ion binding	-	IBA	21873635
GO:0042301	phosphate ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	10819326
GO:0007186	G-protein coupled receptor signaling pathway	-	IEA	-
GO:0021987	cerebral cortex development	-	IBA	21873635
GO:0021987	cerebral cortex development	-	IEA	-
GO:0032496	response to lipopolysaccharide	-	IBA	21873635
GO:0032496	response to lipopolysaccharide	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005834	heterotrimeric G-protein complex	-	IBA	21873635
GO:0005834	heterotrimeric G-protein complex	-	IEA	-
GO:0005884	actin filament	COLOCALIZES_WITH	IBA	21873635
GO:0005884	actin filament	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04062	Chemokine signaling pathway
hsa04810	Regulation of actin cytoskeleton

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-109582	Hemostasis	TAS
R-HSA-111885	Opioid Signalling	TAS
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission	TAS
R-HSA-112315	Transmission across Chemical Synapses	TAS
R-HSA-112316	Neuronal System	TAS
R-HSA-1296041	Activation of G protein gated Potassium channels	TAS
R-HSA-1296059	G protein gated Potassium channels	TAS
R-HSA-1296065	Inwardly rectifying K+ channels	TAS
R-HSA-1296071	Potassium Channels	TAS
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-163359	Glucagon signaling in metabolic regulation	TAS
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-202040	G-protein activation	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373080	Class B/2 (Secretin family receptors)	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	TAS
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	TAS
R-HSA-3858494	Beta-catenin independent WNT signaling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390466	Chaperonin-mediated protein folding	TAS
R-HSA-391251	Protein folding	TAS
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	TAS
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392518	Signal amplification	TAS
R-HSA-392518	Signal amplification	IEA
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	IEA
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	TAS
R-HSA-397795	G-protein beta:gamma signalling	TAS
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	TAS
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	IEA
R-HSA-4086398	Ca2+ pathway	TAS
R-HSA-4086398	Ca2+ pathway	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-418217	G beta:gamma signalling through PLC beta	TAS
R-HSA-418346	Platelet homeostasis	IEA
R-HSA-418346	Platelet homeostasis	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	TAS
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	IEA
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-418597	G alpha (z) signalling events	TAS
R-HSA-420092	Glucagon-type ligand receptors	TAS
R-HSA-422356	Regulation of insulin secretion	TAS
R-HSA-422356	Regulation of insulin secretion	IEA
R-HSA-428930	Thromboxane signalling through TP receptor	TAS
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	TAS
R-HSA-445717	Aquaporin-mediated transport	TAS
R-HSA-451326	Activation of kainate receptors upon glutamate binding	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	TAS
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	IEA
R-HSA-500657	Presynaptic function of Kainate receptors	TAS
R-HSA-500792	GPCR ligand binding	TAS
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	IEA
R-HSA-977443	GABA receptor activation	TAS
R-HSA-977444	GABA B receptor activation	TAS
R-HSA-991365	Activation of GABAB receptors	TAS
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24485148	Differences in smoking associated DNA methylation patterns in South Asians and Europeans. (2014 Feb 3)	Elliott HR	Clin Epigenetics
29055820	IgG glycosylation and DNA methylation are interconnected with smoking. (2018 Mar)	Wahl A	Biochim Biophys Acta
24704585	CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. (2014 Jul)	Harlid S	Environ Health Perspect