Gene: KLHL7

55975
CISS3|KLHL6|SBBI26
kelch like family member 7
protein-coding
7p15.3
Ensembl:ENSG00000122550 MIM:611119 Vega:OTTHUMG00000094813 UniprotKB:Q8IXQ5
NG_016983.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.699e-1 (AD)  3.972e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WASL0.96
ATF20.96
INSIG20.957
VPS350.956
CAND10.956
FAM8A10.955
COL4A3BP0.953
RANBP60.953
GMPS0.952
TRIM230.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.584
OR4F29-0.533
CSAG1-0.399
MTRNR2L10-0.357
MTRNR2L6-0.351
FZD10-0.343
KLRB1-0.338
HEY2-0.338
MTRNR2L9-0.333
ANPEP-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of KLHL7 mRNA"21354444
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of KLHL7 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of KLHL7 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL7 mRNA"27188386
C496492abrineabrine results in increased expression of KLHL7 mRNA22595364
D006710HomocysteineHomocysteine results in decreased expression of KLHL7 mRNA17326132
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of KLHL7 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLHL7 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLHL7 mRNA21839799
C044887beta-methylcholinebeta-methylcholine affects the expression of KLHL7 mRNA21179406
C006780bisphenol Abisphenol A results in increased methylation of KLHL7 gene28505145
C037123cadmium sulfate[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL7 mRNA18654764
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of KLHL7 mRNA23650126
C018021cobaltous chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL7 mRNA18654764
C018021cobaltous chloridecobaltous chloride results in increased expression of KLHL7 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of KLHL7 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of KLHL7 mRNA19549813
D016572CyclosporineCyclosporine results in decreased methylation of KLHL7 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of KLHL7 mRNA25562108
C014347decitabinedecitabine affects the expression of KLHL7 mRNA23300844
D002945CisplatinCisplatin affects the expression of KLHL7 mRNA23300844
D002945CisplatinCisplatin results in increased expression of KLHL7 mRNA27392435|2759478
D004317DoxorubicinDoxorubicin results in increased expression of KLHL7 mRNA25896364
C118739entinostatentinostat results in decreased expression of KLHL7 mRNA27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of KLHL7 mRNA23649840
D005472FluorouracilKLHL7 protein affects the susceptibility to Fluorouracil16217747
C069837fullerene C60fullerene C60 results in decreased expression of KLHL7 mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of KLHL7 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of KLHL7 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of KLHL7 mRNA21179406
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KLHL7 protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of KLHL7 mRNA18951874
D007545IsoproterenolIsoproterenol results in increased expression of KLHL7 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KLHL7 mRNA24796395
D007649KetamineKetamine results in decreased expression of KLHL7 mRNA20080153
C029891lead chloride[cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of KLHL7 mRNA18654764
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of KLHL7 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KLHL7 mRNA23649840
C028007nickel monoxidenickel monoxide results in decreased expression of KLHL7 mRNA19167457
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of KLHL7 mRNA17097637
D010634PhenobarbitalPhenobarbital affects the expression of KLHL7 mRNA23091169
D010672PhenytoinPhenytoin results in increased expression of KLHL7 mRNA20345932
C006253pirinixic acidpirinixic acid results in increased expression of KLHL7 mRNA18301758|2081375
D010936Plant ExtractsPlant Extracts results in increased expression of KLHL7 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in increased expression of KLHL7 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of KLHL7 protein19207037
C059514resveratrolresveratrol results in decreased expression of KLHL7 mRNA25905778
D018038Sodium SeleniteSodium Selenite results in decreased expression of KLHL7 mRNA18175754
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of KLHL7 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of KLHL7 mRNA28065790
D014212TretinoinTretinoin results in decreased expression of KLHL7 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL7 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of KLHL7 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of KLHL7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KLHL7 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased methylation of KLHL7 gene29154799
C025643vinclozolinvinclozolin results in decreased expression of KLHL7 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21828050  
GO:0042802identical protein binding-IPI21828050  
GO:0042803protein homodimerization activity-IDA21828050  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IDA21828050  
GO:0016567protein ubiquitination-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0031463Cul3-RING ubiquitin ligase complex-IDA21828050  
GO:0048471perinuclear region of cytoplasm-IDA27392078  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal