Gene: MAPK11

5600
P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta
mitogen-activated protein kinase 11
protein-coding
22q13.33
Ensembl:ENSG00000185386 MIM:602898 Vega:OTTHUMG00000150226 UniprotKB:Q15759
NG_034042.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.048e-1 (AD)  6.590e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS9D10.939
GPC10.939
PPP6R20.931
DENND6B0.93
DGAT10.929
RNF2150.927
SGSM30.927
PIGQ0.927
EVL0.927
SPG70.926

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.713
OR4F29-0.683
PABPC4L-0.356
SGMS2-0.356
TFPI2-0.355
CD48-0.346
RAI14-0.345
SH2D1A-0.34
MTRNR2L6-0.34
MTRNR2L9-0.339

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05157KC706Small Molecule-InvestigationalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of MAPK11 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of MAPK11 mRNA"23829299
C4086042-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole results in decreased activity of MAPK11 protein14685156
C0264233,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one"3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one results in increased expression of MAPK11 mRNA"23811531
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MAPK11 mRNA"18648102
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased activity of MAPK11 protein10998351
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in decreased activity of MAPK11 protein10620750|1536508
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MAPK11 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MAPK11 protein]26598702
D020106AcrylamideAcrylamide results in increased expression of MAPK11 mRNA28959563
C016601afimoxifeneMAPK11 results in decreased susceptibility to afimoxifene21233418
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MAPK11 mRNA21641981
D000447AldehydesAldehydes results in increased expression of MAPK11 mRNA25014914
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MAPK11 protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased activity of MAPK11 protein12239215
C006632arsenic trioxideMAPK11 protein modified form inhibits the reaction [arsenic trioxide results in increased activity of MAPK11 protein]12239215
C006632arsenic trioxideMAPK11 protein modified form inhibits the reaction [arsenic trioxide results in increased activity of MAPKAPK2 protein]12239215
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of MAPK11 mRNA26377693
D004958EstradiolEstradiol results in increased expression of MAPK11 mRNA23094148
D004958EstradiolIGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAPK11 mRNA]23094148
D004958EstradiolEstradiol results in increased expression of MAPK11 mRNA22314386
D004958EstradiolEstradiol affects the localization of MAPK11 protein modified form24465521
D004958EstradiolEstradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] inhibits the reaction [MAPK11 protein binds to SOD2 protein]]24465521
D004958EstradiolEstradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of MAPK11 protein]24465521
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAPK11 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of MAPK11 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MAPK11 gene28505145
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of MAPK11 mRNA17989939
D019328Buthionine SulfoximineSodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]17989939
C018475butyraldehydebutyraldehyde results in increased expression of MAPK11 mRNA26079696
D002104CadmiumCadmium results in increased expression of MAPK11 mRNA23369406
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [SB 203580 results in decreased expression of MAPK11 mRNA]19757093
D019256Cadmium ChlorideCadmium Chloride inhibits the reaction [SB 203580 results in increased expression of MAPK11 protein]19757093
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MAPK11 mRNA19757093
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MAPK11 protein19757093
D019256Cadmium ChlorideSB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of MAPK11 protein]19757093
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MAPK11 mRNA22314386
D019256Cadmium ChlorideMAPK11 mutant form inhibits the reaction [MAP2K4 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]]18348256
D019256Cadmium ChlorideMAPK11 mutant form promotes the reaction [Cadmium Chloride results in increased expression of HSPA1A protein]18348256
D000068579CelecoxibCelecoxib results in decreased expression of MAPK11 mRNA28201806
D003042CocaineCocaine results in decreased expression of MAPK11 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of MAPK11 mRNA]18355967
D003042CocaineMAPK11 protein affects the susceptibility to Cocaine10620750
D003300CopperCopper deficiency results in increased expression of MAPK11 mRNA26033743
C057862cyanoginosin LRcyanoginosin LR results in increased expression of MAPK11 mRNA25986756
C057862cyanoginosin LRcyanoginosin LR results in increased expression of MAPK11 protein25986756
D016572CyclosporineCyclosporine results in decreased methylation of MAPK11 promoter27989131
D003976DiazinonDiazinon results in increased methylation of MAPK11 gene22964155
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAPK11 promoter23359474
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MAPK11 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MAPK11 mRNA27392435|2759478
D019422Dietary SucroseDietary Sucrose results in increased expression of MAPK11 mRNA26033743
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of MAPK11 promoter23359474
D002117CalcitriolCalcitriol results in increased expression of MAPK11 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MAPK11 mRNA21592394
D004610Ellagic AcidEllagic Acid results in increased expression of MAPK11 mRNA23811531
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MAPK11 mRNA23649840
D005480FlurbiprofenMAPK11 protein promotes the reaction [Flurbiprofen results in increased expression of NGFR protein]18056468
C061365flusilazoleflusilazole results in decreased expression of MAPK11 mRNA22382673
D019833GenisteinGenistein results in decreased phosphorylation of MAPK11 protein19497411
D006427HeminHemin inhibits the reaction [IL18 protein results in decreased expression of MAPK11 protein]18215737
D007052IbuprofenMAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]18056468
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MAPK11 mRNA27392435
C544151jinfukangjinfukang results in increased expression of MAPK11 mRNA27392435
C008261lead acetatelead acetate results in increased expression of MAPK11 mRNA21322097
C008261lead acetatelead acetate affects the expression of MAPK1124293362
D008694MethamphetamineMethamphetamine results in increased expression of MAPK11 mRNA26307267
D008727MethotrexateMethotrexate results in increased expression of MAPK11 mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MAPK11 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine affects the expression of MAPK11 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MAPK11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MAPK11 mRNA"25554681
D009538NicotineNicotine results in decreased expression of MAPK11 mRNA17135361
C464660obeticholic acidobeticholic acid results in decreased expression of MAPK11 mRNA27939613
D009930Organic ChemicalsOrganic Chemicals results in increased expression of MAPK11 mRNA20526952
D010100OxygenEstradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] inhibits the reaction [MAPK11 protein binds to SOD2 protein]]24465521
D010100OxygenEstradiol inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of MAPK11 protein]24465521
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] inhibits the reaction [MAPK11 protein binds to SOD2 protein]24465521
D010100Oxygen[Oxygen deficiency co-treated with Oxygen] results in decreased activity of MAPK11 protein24465521
D010269Paraquat[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK11 protein24376630
C046012pentanalpentanal results in increased expression of MAPK11 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of MAPK11 mRNA23557933
D011720PyrazolesPyrazoles analog results in decreased activity of MAPK11 protein12534346
D011743PyrimidinesPyrimidines analog results in decreased activity of MAPK11 protein12534346
D011794QuercetinQuercetin results in increased expression of MAPK11 mRNA27514524
D017382Reactive Oxygen Species[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK11 protein24376630
C093642SB 203580Cadmium Chloride inhibits the reaction [SB 203580 results in decreased expression of MAPK11 mRNA]19757093
C093642SB 203580Cadmium Chloride inhibits the reaction [SB 203580 results in increased expression of MAPK11 protein]19757093
C093642SB 203580SB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of MAPK11 protein]19757093
C093642SB 203580SB 203580 inhibits the reaction [MAPK11 protein results in increased phosphorylation of SOD2 protein]24465521
C093642SB 203580SB 203580 results in decreased activity of MAPK11 protein10998351
C093642SB 203580SB 203580 results in decreased expression of MAPK11 mRNA19757093
C093642SB 203580SB 203580 results in increased expression of MAPK11 protein19757093
C093642SB 203580SB 203580 results in decreased activity of MAPK11 protein24376630
C093642SB 203580SB 203580 results in decreased activity of MAPK11 protein14685156|1845767
D012643SeleniumSelenium results in increased expression of MAPK11 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased phosphorylation of and results in increased activity of MAPK11 protein15504454
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]17989939
D018038Sodium SeleniteSodium Selenite results in decreased expression of MAPK11 mRNA17989939
D018038Sodium SeleniteSodium Selenite results in increased expression of MAPK11 mRNA19363675
D018038Sodium SeleniteSodium Selenite results in increased expression of MAPK11 protein19363675
D013629TamoxifenTamoxifen results in decreased expression of MAPK11 mRNA15590111
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MAPK11 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MAPK11 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAPK11 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAPK11 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAPK11 mRNA22808131
C009495titanium dioxidetitanium dioxide results in increased expression of MAPK11 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MAPK11 mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of MAPK11 mRNA"19682533
C012589trichostatin Atrichostatin A results in increased expression of MAPK11 mRNA15901671
C057693troglitazoneMAPK11 protein affects the reaction [troglitazone results in increased expression of GADD45A mRNA]15064713
D014635Valproic AcidValproic Acid affects the expression of MAPK11 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MAPK11 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased methylation of MAPK11 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MAPK11 mRNA15901671
D014800VitalliumVitallium analog results in decreased expression of MAPK11 mRNA23825117
D014810Vitamin EVitamin E results in increased expression of MAPK11 mRNA19244175
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of MAPK11 mRNA"20526952

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-TAS-  
GO:0004707MAP kinase activity-IBA21873635  
GO:0004707MAP kinase activity-IDA8663524  10330143  
GO:0005515protein binding-IPI17254968  17380123  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-TAS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0010468regulation of gene expression-IBA21873635  
GO:0010628positive regulation of gene expression-IMP25754930  
GO:0035556intracellular signal transduction-IBA21873635  
GO:0045648positive regulation of erythrocyte differentiationNOTIMP23483889  
GO:0051149positive regulation of muscle cell differentiation-TAS-  
GO:0051403stress-activated MAPK cascade-IDA8663524  
GO:0060044negative regulation of cardiac muscle cell proliferation-IEA-  
GO:0071310cellular response to organic substance-IBA21873635  
GO:0071347cellular response to interleukin-1-IDA8663524  
GO:0098586cellular response to virus-IMP25754930  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:2001184positive regulation of interleukin-12 secretion-IMP25754930  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1592230Mitochondrial biogenesisIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-166016Toll Like Receptor 4 (TLR4) CascadeTAS
R-HSA-166058MyD88:Mal cascade initiated on plasma membraneTAS
R-HSA-166166MyD88-independent TLR4 cascade TAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-167044Signalling to RASTAS
R-HSA-167044Signalling to RASIEA
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168142Toll Like Receptor 10 (TLR10) CascadeTAS
R-HSA-168164Toll Like Receptor 3 (TLR3) CascadeTAS
R-HSA-168176Toll Like Receptor 5 (TLR5) CascadeTAS
R-HSA-168179Toll Like Receptor TLR1:TLR2 CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168188Toll Like Receptor TLR6:TLR2 CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168638NOD1/2 Signaling PathwayTAS
R-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-171007p38MAPK eventsTAS
R-HSA-171007p38MAPK eventsIEA
R-HSA-181438Toll Like Receptor 2 (TLR2) CascadeTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-187037Signaling by NTRK1 (TRKA)IEA
R-HSA-187687Signalling to ERKsTAS
R-HSA-187687Signalling to ERKsIEA
R-HSA-194138Signaling by VEGFTAS
R-HSA-198725Nuclear Events (kinase and transcription factor activation)TAS
R-HSA-198753ERK/MAPK targetsTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylationIEA
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-373752Netrin-1 signalingTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-375170CDO in myogenesisTAS
R-HSA-376172DSCAM interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-448424Interleukin-17 signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinasesTAS
R-HSA-450294MAP kinase activationTAS
R-HSA-450302activated TAK1 mediates p38 MAPK activationTAS
R-HSA-450341Activation of the AP-1 family of transcription factorsTAS
R-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elementsIEA
R-HSA-450604KSRP (KHSRP) binds and destabilizes mRNAIEA
R-HSA-525793MyogenesisIEA
R-HSA-525793MyogenesisTAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953854Metabolism of RNAIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling TAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS
R-HSA-975871MyD88 cascade initiated on plasma membraneTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22415779p38 Mitogen-activated protein kinase signaling, ERCC1 expression, and viability of lung cancer cells from never or light smoker patients. (2012 Oct 15)Planchard DCancer