Gene: PDGFC

56034
FALLOTEIN|SCDGF
platelet derived growth factor C
protein-coding
4q32.1
Ensembl:ENSG00000145431 MIM:608452 Vega:OTTHUMG00000161803 UniprotKB:Q9NRA1
NC_000004.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.579e-1 (AD)  2.038e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12651147chr4:156791807 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPNE30.804
PDLIM50.793
LIX1L0.782
NADK20.771
PIK3C2A0.765
PSAT10.764
TEAD10.758
DPY19L30.757
EPB41L50.757
ELP40.756

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.455
OR4F29-0.426
RTP1-0.341
PKLR-0.33
C2CD4D-0.319
OPRD1-0.313
DRGX-0.309
PDF-0.304
KNCN-0.303
THEM5-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of PDGFC mRNA"26377693
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of PDGFC mRNA"26644586
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [TGFB1 protein results in increased expression of PDGFC mRNA]"25280005
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDGFC gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PDGFC mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PDGFC mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of PDGFC mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDGFC mRNA16483693
D001151ArsenicArsenic affects the expression of PDGFC protein24675094
C015001arsenitearsenite results in increased methylation of PDGFC promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDGFC mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDGFC mRNA20713471|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDGFC mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of PDGFC mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PDGFC mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of PDGFC mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of PDGFC mRNA25270620
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PDGFC mRNA18974090
D002220CarbamazepineCarbamazepine affects the expression of PDGFC mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDGFC mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFC20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDGFC gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFC mRNA20548288|2093899
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PDGFC mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDGFC mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDGFC mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PDGFC mRNA20971185
D003471CuprizoneCuprizone results in increased expression of PDGFC mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of PDGFC mRNA27989131
D003907DexamethasoneDexamethasone results in increased expression of PDGFC mRNA21041162|2273378
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDGFC mRNA27392435
D004026DieldrinDieldrin results in increased expression of PDGFC mRNA28385952
D004041Dietary FatsDietary Fats results in decreased expression of PDGFC mRNA18042831
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDGFC mRNA22079256
D005047EtoposidePDGFC protein affects the susceptibility to Etoposide16217747
D005485FlutamideFlutamide results in increased expression of PDGFC mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFC20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDGFC gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFC mRNA20548288|2093899
C039281furanfuran results in increased methylation of PDGFC gene22079235
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of PDGFC mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of PDGFC mRNA26644586
D017313FenretinideFenretinide results in decreased expression of PDGFC mRNA28973697
D017313FenretinideFenretinide results in increased expression of PDGFC mRNA28973697
C492448ICG 001ICG 001 results in increased expression of PDGFC mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDGFC mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PDGFC mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of PDGFC mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFC mRNA24796395|2664458
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFC mRNA26644586
C008261lead acetatelead acetate results in increased expression of PDGFC mRNA22609695
C533894LG 100815LG 100815 results in increased expression of PDGFC mRNA16951191
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PDGFC mRNA"23306164
C042720mercuric bromidemercuric bromide results in increased expression of PDGFC mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFC20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDGFC gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFC mRNA20548288|2093899
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PDGFC mRNA23649840
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PDGFC mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PDGFC mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PDGFC mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of PDGFC mRNA20971185
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of PDGFC mRNA"16951191
D000073878Palm OilPalm Oil results in decreased expression of PDGFC mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PDGFC mRNA26272509
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PDGFC mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PDGFC mRNA19429403
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PDGFC mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of PDGFC mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of PDGFC mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of PDGFC mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PDGFC mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDGFC mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDGFC mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDGFC mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of PDGFC mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PDGFC mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of PDGFC mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDGFC mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of PDGFC mRNA21795629
D012999SomanSoman results in increased expression of PDGFC mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDGFC mRNA28922406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDGFC mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PDGFC mRNA28973375
D013853ThioacetamideThioacetamide results in increased expression of PDGFC mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDGFC mRNA28065790
D019772TopotecanPDGFC protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in increased expression of PDGFC mRNA21934132
D014212TretinoinTretinoin results in decreased expression of PDGFC protein16956736
D014212TretinoinTretinoin results in increased expression of PDGFC mRNA17066417
D014212TretinoinTretinoin results in increased expression of PDGFC protein17066417
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PDGFC mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFC mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PDGFC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PDGFC gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PDGFC mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased expression of PDGFC mRNA21427059
D014638VanadatesVanadates results in increased expression of PDGFC mRNA22714537
C066075vanadium pentoxidevanadium pentoxide results in increased expression of PDGFC mRNA17134509
C111237vorinostatvorinostat results in increased expression of PDGFC mRNA26272509
C088658zoledronic acidzoledronic acid results in decreased expression of PDGFC mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005161platelet-derived growth factor receptor binding-IBA21873635  
GO:0005161platelet-derived growth factor receptor binding-IPI10806482  
GO:0005515protein binding-IPI10806482  
GO:0008083growth factor activity-IEA-  
GO:0042803protein homodimerization activity-IPI10806482  
GO:0070851growth factor receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007171activation of transmembrane receptor protein tyrosine kinase activity-IEA-  
GO:0007417central nervous system development-TAS10858496  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA10806482  
GO:0009790embryo development-IEA-  
GO:0009887animal organ morphogenesis-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IBA21873635  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0031954positive regulation of protein autophosphorylation-IBA21873635  
GO:0043406positive regulation of MAP kinase activity-IBA21873635  
GO:0048008platelet-derived growth factor receptor signaling pathway-IBA21873635  
GO:0048008platelet-derived growth factor receptor signaling pathway-IDA10806482  
GO:0048146positive regulation of fibroblast proliferation-IDA10806482  
GO:0048565digestive tract development-IEA-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-IEA-  
GO:0051781positive regulation of cell division-IEA-  
GO:0060348bone development-IEA-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA10806482  
GO:0005634nucleus-IEA-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0009986cell surface-IDA10806482  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal