Gene: PCDHB2

56133
PCDH-BETA2
protocadherin beta 2
protein-coding
5q31.3
Ensembl:ENSG00000112852 MIM:606328 Vega:OTTHUMG00000129606 UniprotKB:Q9Y5E7
NC_000005.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.601e-1 (AD)  7.399e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNH10.791
SLC4A80.778
PCDHAC20.777
SCN8A0.776
TCP11L10.776
STXBP50.77
NEU30.765
ATXN30.762
MKL20.762
USP320.76

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.471
ROM1-0.447
STON2-0.442
HIST1H1C-0.43
RAB13-0.423
EYA2-0.42
FXYD3-0.419
GPR143-0.418
BBOX1-0.417
ACOX2-0.416

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDHB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDHB2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PCDHB2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCDHB2 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of PCDHB2 mRNA25181051
D002330CarmustinePCDHB2 mRNA affects the susceptibility to Carmustine16365179
D003300CopperCopper deficiency results in increased expression of PCDHB2 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of PCDHB2 mRNA20106945
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PCDHB2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PCDHB2 mRNA27392435
D019833GenisteinGenistein results in increased expression of PCDHB2 mRNA20884965
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PCDHB2 mRNA27392435
C008261lead acetatelead acetate results in increased expression of PCDHB2 mRNA22613225
C523799MRK 003MRK 003 results in decreased expression of PCDHB2 mRNA21169257
D010634PhenobarbitalPhenobarbital affects the expression of PCDHB2 mRNA19159669
D011794QuercetinQuercetin results in decreased expression of PCDHB2 mRNA21632981
C047246temozolomidePCDHB2 mRNA affects the susceptibility to temozolomide16365179
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCDHB2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PCDHB2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PCDHB2 mRNA26272509|2800136
C111237vorinostatvorinostat results in decreased expression of PCDHB2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0007155cell adhesion-TAS10380929  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007268chemical synaptic transmission-TAS12231349  
GO:0007399nervous system development-TAS10380929  
GO:0007416synapse assembly-TAS12231349  
GO:0016339calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules-NAS11322959  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10380929  
GO:0016021integral component of membrane-NAS11322959  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res