Gene: PCDHA6

56142
CNR2|CNRN2|CNRS2|CRNR2|PCDH-ALPHA6
protocadherin alpha 6
protein-coding
5q31.3
Ensembl:ENSG00000081842 MIM:606312 Vega:OTTHUMG00000163353 UniprotKB:Q9UN73
NC_000005.10
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.576e-1 (AD)  1.501e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDHA50.893
KCNH10.884
PCDHAC20.883
SCN8A0.875
PPM1E0.873
CDKL20.864
GRM50.858
GPLD10.857
SLC4A80.855
C1QL30.855

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.585
STON2-0.58
RNF135-0.558
HIST1H1C-0.547
S100A16-0.544
COPZ2-0.544
GNG5-0.544
ROM1-0.543
HEY2-0.535
AKR1C3-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCDHA6 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCDHA6 mRNA16483693
D001374AzacitidineAzacitidine affects the methylation of PCDHA6 promoter18204046
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PCDHA6 promoter22457795
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PCDHA6 mRNA18668222
D007854LeadLead affects the expression of PCDHA6 mRNA28903495
D008345ManganeseManganese results in increased expression of PCDHA6 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of PCDHA6 mRNA17175027
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCDHA6 mRNA23103053
D010126OzoneOzone results in decreased expression of PCDHA6 mRNA12763052
C006253pirinixic acidpirinixic acid results in decreased expression of PCDHA6 mRNA23811191
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of PCDHA6 mRNA"16251409
C009495titanium dioxidetitanium dioxide results in decreased expression of PCDHA6 mRNA23557971|2776080

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0007155cell adhesion-TAS10380929  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-IEA-  
GO:0007267cell-cell signaling-IBA21873635  
GO:0007399nervous system development-TAS10380929  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10380929  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal