Gene: STK31

56164
SGK396|TDRD8
serine/threonine kinase 31
protein-coding
7p15.3
Ensembl:ENSG00000196335 MIM:605790 Vega:OTTHUMG00000023053 UniprotKB:Q9BXU1
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.463e-1 (AD)  9.364e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12666547chr7:23792484 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13514718chr7:23749722STK31Promoter4.115e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PDE6B0.593
ENO40.587
ZNF2260.58
NR2C10.56
OVGP10.558
SYCP2L0.557
KCNH80.555
HSD17B30.554
ANAPC40.551
TFAP2E0.551

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP1LC3C-0.309
FOXJ1-0.285
MTRNR2L9-0.277
SPRY1-0.277
TTLL10-0.276
RAB39A-0.269
MTRNR2L2-0.268
G0S2-0.26
EVC2-0.257
WDR38-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001280AtrazineAtrazine results in increased expression of STK31 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STK31 mRNA22316170
D004958EstradiolEstradiol affects the expression of STK31 mRNA23557687
C018475butyraldehydebutyraldehyde results in decreased expression of STK31 mRNA26079696
D004008DiclofenacDiclofenac results in decreased expression of STK31 mRNA26934552
D052638Particulate MatterParticulate Matter results in increased expression of STK31 mRNA28366736
C005556propionaldehydepropionaldehyde results in increased expression of STK31 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of STK31 mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of STK31 protein28918527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STK31 mRNA16962184

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004518nuclease activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006401RNA catabolic process-IBA21873635  
GO:0006468protein phosphorylation-IEA-  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001669acrosomal vesicle-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal