Gene: DNAH7

56171
-
dynein axonemal heavy chain 7
protein-coding
2q32.3
Ensembl:ENSG00000118997 MIM:610061 Vega:OTTHUMG00000154438 UniprotKB:Q8WXX0
NC_000002.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.003e-1 (AD)  4.262e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6743998chr2:195811765 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6434799chr2:195800359 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAPLN0.808
OPHN10.805
GPR750.795
RYR30.794
DOCK70.792
EHHADH0.774
INTU0.769
TNIK0.765
ATP13A40.754
PCDHGA30.75

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK8-0.34
CD96-0.328
CETP-0.328
GRAP2-0.326
SULT2B1-0.325
GADL1-0.318
LY9-0.316
IL7R-0.315
CD244-0.315
GZMA-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000638AmiodaroneAmiodarone results in increased expression of DNAH7 mRNA19774075
D001104ArbutinArbutin results in decreased expression of DNAH7 mRNA17103032
D001151ArsenicArsenic affects the methylation of DNAH7 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of DNAH7 mRNA20458559
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of DNAH7 gene25435355
C006780bisphenol Abisphenol A affects the expression of DNAH7 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of DNAH7 protein24552547
D002509CephaloridineCephaloridine results in decreased expression of DNAH7 mRNA18500788
C029892cupric chloridecupric chloride results in decreased expression of DNAH7 mRNA24650576
D013759DronabinolDronabinol results in decreased expression of DNAH7 mRNA16616335
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DNAH7 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DNAH7 mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DNAH7 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DNAH7 mRNA27392435
C002385linsidominelinsidomine results in increased oxidation of DNAH7 protein28086193
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of DNAH7 mRNA16966085
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of DNAH7 mRNA23948077
C005556propionaldehydepropionaldehyde results in increased expression of DNAH7 mRNA26079696
D012402RotenoneRotenone results in increased expression of DNAH7 mRNA27979718
D014635Valproic AcidValproic Acid results in increased expression of DNAH7 mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IC11877439  
GO:0003777microtubule motor activity-NAS9373155  
GO:0005509calcium ion binding-IEA-  
GO:0005524ATP binding-IEA-  
GO:0008569ATP-dependent microtubule motor activity, minus-end-directed-IBA21873635  
GO:0045503dynein light chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0003341cilium movement-IBA21873635  
GO:0003341cilium movement-IMP11877439  
GO:0007018microtubule-based movement-IBA21873635  
GO:0036159inner dynein arm assembly-IBA21873635  
GO:0036159inner dynein arm assembly-IMP11877439  
GO:0060285cilium-dependent cell motility-NAS9373155  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005858axonemal dynein complex-IBA21873635  
GO:0005858axonemal dynein complex-NAS9373155  
GO:0005874microtubule-IEA-  
GO:0005929cilium-IDA11877439  
GO:0030286dynein complex-IBA21873635  
GO:0036156inner dynein arm-IBA21873635  
GO:0036156inner dynein arm-IMP11877439  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal