Gene: PRM1

5619
CT94.1|P1
protamine 1
protein-coding
16p13.13
Ensembl:ENSG00000175646 MIM:182880 Vega:OTTHUMG00000090521 UniprotKB:P04553
NC_000016.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.061e-1 (AD)  7.908e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05385299chr16:11376309PRM1Promoter3.417e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRM20.906
TNP10.837
BOD1L20.636
AKAP40.605
TUBA3C0.583
UBQLN30.57
HMGB40.557
LELP10.554
C16orf820.551
ZG16B0.525

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN20-0.276
SPATA31C1-0.256
H2BFM-0.245
EXOG-0.237
RXFP4-0.234
VWDE-0.233
AMDHD1-0.228
L3MBTL3-0.228
MPP4-0.224
TCTEX1D1-0.223

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PRM1 mRNA"18281256
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRM1 mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of PRM1 mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PRM1 mRNA"28712647
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRM1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRM1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRM1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRM1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of PRM1 mRNA"23829299
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRM1 mRNA16483693
C006780bisphenol Abisphenol A results in decreased expression of PRM1 mRNA23798566
C006780bisphenol Abisphenol A results in decreased expression of PRM1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PRM1 promoter22457795
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PRM1 mRNA23650126
D003042CocaineHDAC5 affects the reaction [Cocaine affects the expression of PRM1 mRNA]17988634
C010974glyphosateglyphosate results in decreased expression of PRM124930125
D006540HerbicidesHerbicides results in decreased expression of PRM124930125
D017313FenretinideFenretinide results in decreased expression of PRM1 mRNA16467112
C017461lead nitratelead nitrate results in decreased expression of PRM1 mRNA21628963
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of PRM1 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PRM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRM1 mRNA"25554681
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PRM1 mRNA"25510870
C410127PCB 180PCB 180 results in increased expression of PRM1 mRNA23829299
C006253pirinixic acidpirinixic acid results in decreased expression of PRM1 mRNA17950772
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of PRM1 mRNA]17950772
D011344ProcarbazineProcarbazine results in decreased expression of PRM1 mRNA8226304
D012969Sodium FluorideSodium Fluoride results in decreased expression of PRM1 mRNA22865829
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRM1 mRNA21296121
D014118Toxins, Biological"Toxins, Biological affects the expression of PRM1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of PRM1 mRNA18425777
D014635Valproic AcidValproic Acid results in increased methylation of PRM1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of PRM1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006323DNA packaging-TAS2081589  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0030261chromosome condensation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000786nucleosome-IEA-  
GO:0005654nucleoplasm-TAS2081589  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28969455The impact of cigarette smoking on protamines 1 and 2 transcripts in human spermatozoa. (2017 Oct 2)Hamad MHum Fertil (Camb)