Gene: PRM2

5620
CT94.2
protamine 2
protein-coding
16p13.13
Ensembl:ENSG00000122304 MIM:182890 Vega:OTTHUMG00000172317 UniprotKB:P04554
NC_000016.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.929e-1 (AD)  8.003e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRM10.906
TNP10.81
BOD1L20.681
AKAP40.629
TUBA3C0.595
LELP10.593
ACTL7A0.591
UBQLN30.581
HMGB40.556
ZG16B0.525

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLDN20-0.283
DCDC1-0.267
SPATA31C1-0.253
VWDE-0.246
ABCA10-0.243
LANCL3-0.238
MPP4-0.236
KLB-0.236
WFDC13-0.233
L3MBTL3-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PRM2 mRNA"28712647
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRM2 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of PRM2 mRNA22641617
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in decreased expression of PRM2 mRNA]27174447
D004958EstradiolEstradiol results in decreased expression of PRM2 mRNA27174447
C452139BIRB 796BIRB 796 results in increased expression of PRM2 mRNA21328587
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in decreased expression of PRM2 mRNA]27174447
C006780bisphenol Abisphenol A results in decreased expression of PRM2 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of PRM2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRM2 mRNA24982889
D002330CarmustineCarmustine results in decreased expression of PRM2 mRNA15980968
D003300CopperCopper deficiency results in increased expression of PRM2 mRNA26033743
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRM2 mRNA23914054
D019422Dietary SucroseDietary Sucrose results in increased expression of PRM2 mRNA26033743
D015025ZearalenoneZearalenone results in increased expression of PRM2 mRNA25455459
D005419FlavonoidsFlavonoids results in increased expression of PRM2 mRNA18035473
C500085muraglitazarmuraglitazar results in decreased expression of PRM2 mRNA21515302
D010936Plant ExtractsPlant Extracts results in decreased expression of PRM2 mRNA23557933
C089730rosiglitazonerosiglitazone results in decreased expression of PRM2 mRNA21515302
D012969Sodium FluorideSodium Fluoride results in decreased expression of PRM2 mRNA21340527|2286582
C501413tesaglitazartesaglitazar results in decreased expression of PRM2 mRNA21515302
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRM2 mRNA27589885
D014118Toxins, Biological"Toxins, Biological affects the expression of PRM2 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PRM2 gene27618143
C057693troglitazonetroglitazone results in decreased expression of PRM2 mRNA21515302
D014635Valproic AcidValproic Acid results in increased methylation of PRM2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-IDA2243113  
GO:0046870cadmium ion binding-IDA2243113  
GO ID GO Term Qualifier Evidence PubMed
GO:0006323DNA packaging-TAS2081589  
GO:0006997nucleus organization-IBA21873635  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0007286spermatid development-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000786nucleosome-IEA-  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS2081589  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28969455The impact of cigarette smoking on protamines 1 and 2 transcripts in human spermatozoa. (2017 Oct 2)Hamad MHum Fertil (Camb)
19409198Use of spermatozoal mRNA profiles to study gene-environment interactions in human germ cells. (2009 Jul 10)Linschooten JOMutat Res