Gene: FAM214A

56204
KIAA1370
family with sequence similarity 214 member A
protein-coding
15q21.2-q21.3
Ensembl:ENSG00000047346 Vega:OTTHUMG00000172688 UniprotKB:Q32MH5
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.012e-1 (AD)  5.233e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2433285chr15:52705779 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC88A0.825
ARID4B0.823
SENP60.82
PRPF40A0.82
GCLC0.818
UBXN40.81
TBC1D150.809
N4BP2L20.808
PHIP0.806
PAN30.805

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.544
OR4F5-0.525
OR4F16-0.222
CMA1-0.212
RNF223-0.21
KRTAP19-1-0.192
HMHB1-0.183
SULT2B1-0.181
WNT7B-0.18
GOLGA6L1-0.18

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of FAM214A mRNA25596134
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in increased expression of FAM214A mRNA"23136191
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine results in increased expression of FAM214A mRNA"23136191
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of FAM214A mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FAM214A mRNA"19167446
D000082AcetaminophenAcetaminophen affects the expression of FAM214A mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of FAM214A mRNA19420014
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FAM214A mRNA21641981|2715375
D000393Air PollutantsAir Pollutants analog results in decreased expression of FAM214A mRNA21757418
D000638AmiodaroneAmiodarone affects the expression of FAM214A mRNA25064622
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of FAM214A mRNA"18687144
D001507BeclomethasoneBeclomethasone results in increased expression of FAM214A mRNA23656298
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of FAM214A mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FAM214A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FAM214A mRNA21632981
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM214A mRNA28628672
C006780bisphenol Abisphenol A affects the expression of FAM214A mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of FAM214A mRNA25594700
C006780bisphenol Abisphenol A affects the expression of FAM214A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FAM214A mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FAM214A mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FAM214A mRNA27339419
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of FAM214A mRNA25596134
D002746ChlorpromazineChlorpromazine affects the expression of FAM214A mRNA25064622
C059262cidofovircidofovir results in decreased expression of FAM214A mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of FAM214A mRNA25596134
D002994ClofibrateClofibrate results in decreased expression of FAM214A mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of FAM214A mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of FAM214A mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of FAM214A mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of FAM214A mRNA19167446
D016572CyclosporineCyclosporine affects the expression of FAM214A mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of FAM214A mRNA21632981|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM214A mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of FAM214A mRNA22733784
D002945CisplatinCisplatin results in decreased expression of FAM214A mRNA25596134
D004237DiuronDiuron results in increased expression of FAM214A mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of FAM214A mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FAM214A mRNA25064622
D011345FenofibrateFenofibrate results in decreased expression of FAM214A mRNA25596134
C000499ferric oxideferric oxide analog results in increased expression of FAM214A mRNA25086211
D005485FlutamideFlutamide results in increased expression of FAM214A mRNA24793618
D005897GlafenineGlafenine results in decreased expression of FAM214A mRNA24136188
D017313FenretinideFenretinide results in decreased expression of FAM214A mRNA28973697
D007069IfosfamideIfosfamide results in decreased expression of FAM214A mRNA25596134
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM214A mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM214A mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of FAM214A mRNA28628672
C544151jinfukangjinfukang results in decreased expression of FAM214A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of FAM214A mRNA24796395
C045463leflunomideleflunomide results in decreased expression of FAM214A mRNA24136188
D008687MetforminMetformin results in decreased expression of FAM214A mRNA25596134
D008701MethapyrileneMethapyrilene results in increased expression of FAM214A mRNA28935588
D009151Mustard GasMustard Gas results in increased expression of FAM214A mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FAM214A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FAM214A mRNA"25554681|2562005
D009285NaphthoquinonesNaphthoquinones results in increased expression of FAM214A mRNA23811387
C051752nefazodonenefazodone results in decreased expression of FAM214A mRNA24136188
C012655nimesulidenimesulide results in decreased expression of FAM214A mRNA24136188
D010100OxygenOxygen deficiency results in decreased expression of FAM214A mRNA25596134
D010269ParaquatParaquat affects the expression of FAM214A mRNA25064622
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of FAM214A mRNA27153767
C006253pirinixic acidpirinixic acid results in decreased expression of FAM214A mRNA23811191
D010938Plant OilsPlant Oils results in increased expression of FAM214A mRNA23370395
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FAM214A mRNA22714537
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of FAM214A mRNA19167446
C089730rosiglitazonerosiglitazone results in decreased expression of FAM214A mRNA25596134
C089730rosiglitazonerosiglitazone results in decreased expression of FAM214A mRNA25596134
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FAM214A mRNA25895662
D012906SmokeSmoke affects the expression of FAM214A mRNA23693141
C016104sodium bichromatesodium bichromate results in decreased expression of FAM214A mRNA25993096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FAM214A mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FAM214A mRNA21215274|2172422
D013752TetracyclineTetracycline affects the expression of FAM214A mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FAM214A mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of FAM214A mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FAM214A mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of FAM214A mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FAM214A mRNA"26179874
D014520UrethaneUrethane results in increased expression of FAM214A mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of FAM214A mRNA25064622
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FAM214A gene25560391
D015032ZincZinc deficiency results in decreased expression of FAM214A mRNA16140947
D015032ZincZinc inhibits the reaction [Zinc deficiency results in decreased expression of FAM214A mRNA]16140947
C088658zoledronic acidzoledronic acid results in increased expression of FAM214A mRNA25596134

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal