Gene: PRNP

5621
ASCR|AltPrP|CD230|CJD|GSS|KURU|PRIP|PrP|PrP27-30|PrP33-35C|PrPc|p27-30
prion protein
protein-coding
20p13
Ensembl:ENSG00000171867 MIM:176640 Vega:OTTHUMG00000031786 UniprotKB:F7VJQ1
NG_009087.1
PubMed|SNP Mapped
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.403e-1 (AD)  4.412e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11087653chr20:4698873 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARL8B0.966
GHITM0.963
COPS80.958
DNAJA20.955
PNMA10.955
VDAC20.951
TERF2IP0.951
ACSL30.95
RAB1A0.949
EIF4A20.949

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.779
OR4F29-0.74
TFPI2-0.376
KLRB1-0.372
KLRF1-0.351
TBX21-0.345
SLAMF6-0.341
IL18RAP-0.339
IL2RB-0.335
FCRL3-0.329

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00759TetracyclineSmall Molecule60-54-8ApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PRNP mRNA"25270620
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRNP mRNA"25305463
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA]17387271
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRNP mRNA"19114083
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PRNP mRNA"20206263
C0261142-xylene2-xylene results in increased expression of PRNP mRNA20359517
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PRNP mRNA"23196670
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of PRNP mRNA"24172598
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PRNP mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PRNP mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to PRNP protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PRNP protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of PRNP mRNA21420995|2223033
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]14713301
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRNP mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PRNP mRNA19770486
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PRNP mRNA23630614
C430898AGN 194204AGN 194204 results in decreased expression of PRNP mRNA16339527
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of PRNP mRNA17023530
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRNP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PRNP mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PRNP protein]26598702
D001241AspirinAspirin results in increased expression of PRNP mRNA12800193
D001280AtrazineAtrazine results in decreased expression of PRNP mRNA25929836
D001280AtrazineAtrazine results in decreased expression of PRNP mRNA22378314
C028559bathocuproine sulfonatebathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein]16148034
D001554BenzeneBenzene results in increased expression of PRNP mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PRNP promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRNP mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PRNP mRNA"26238291
C038328BEP protocolBEP protocol results in increased expression of PRNP mRNA18987330
D004958EstradiolEstradiol affects the expression of PRNP mRNA22574217
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of PRNP mRNA24758408
C095105bexarotenebexarotene results in decreased expression of PRNP mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of PRNP mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of PRNP mRNA29275510
C006780bisphenol Abisphenol A affects the methylation of PRNP promoter27334623
C006780bisphenol Abisphenol A affects the expression of PRNP mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of PRNP mRNA12075121
D000069286BortezomibBortezomib results in increased expression of PRNP mRNA20977926
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PRNP mRNA15336504
D020148Butyric AcidButyric Acid results in increased expression of PRNP mRNA12800193
C584509C646 compoundC646 compound results in increased expression of PRNP mRNA26191083
D002104CadmiumCadmium results in increased ubiquitination of PRNP protein22995398
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRNP mRNA12760830
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PRNP mRNA16148034
D002110CaffeineCaffeine results in decreased expression of PRNP mRNA18444173
D002220CarbamazepineCarbamazepine affects the expression of PRNP mRNA25979313
C100187chloropicrinchloropicrin results in decreased expression of PRNP mRNA26352163
D009249NADP[Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]19149680
D009249NADP[Copper co-treated with NADP] results in increased susceptibility to [PRNP protein binds to PRNP protein]19149680
D009249NADP[NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein]16990274
D003224Congo RedCongo Red results in decreased expression of PRNP protein alternative form11994310
D003300CopperCopper binds to PRNP protein14703517
D003300CopperCopper affects the folding of PRNP protein16791441
D003300CopperCopper affects the folding of PRNP protein modified form20936829
D003300Copper[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein16595185
D003300CopperPRNP protein binds to Copper17112476
D003300Copper[PRNP protein binds to Copper] which results in increased activity of SOD1 protein17112476
D003300CopperCopper affects the folding of PRNP protein modified form20936829
D003300Copper"Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form]"20936829
D003300CopperCopper binds to PRNP protein16824036|1683196
D003300Copper[Copper binds to PRNP protein] which results in increased reduction of Copper19697239
D003300Copper[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species19697239
D003300Copper[[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of PRNP protein19697239
D003300Copper[Copper co-treated with NADP] promotes the reaction [PRNP protein binds to PRNP protein]19149680
D003300Copper[Copper co-treated with NADP] results in increased susceptibility to [PRNP protein binds to PRNP protein]19149680
D003300CopperCopper results in increased cleavage of PRNP protein19597535
D003300CopperPRNP protein binds to Copper16847141|1711247
D003300Copper[PRNP protein binds to Copper] which results in increased activity of SOD1 protein17112476
D003300CopperPRNP protein polymorphism binds to Copper16847141
D003300CopperPRNP protein results in decreased susceptibility to Copper21537833
D003300CopperPRNP protein results in increased reduction of Copper12572668
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PRNP mRNA15467011
D003300CopperCAT protein inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]16595185
D003300CopperCAT protein inhibits the reaction [[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]16595185
D003300CopperCopper affects the localization of [GPC1 protein co-treated with PRNP protein]16923158
D003300CopperCopper affects the reaction [LRP1 protein results in increased uptake of PRNP protein]17155929
D003300CopperCopper binds to PRNP protein16698781|1699027
D003300Copper[Copper co-treated with Filipin] results in increased cleavage of PRNP protein19597535
D003300CopperCopper promotes the reaction [PRNP protein binds to GRIN1 protein]22307640
D003300CopperCopper results in increased transport of PRNP protein21172064
D003300CopperCopper results in increased uptake of PRNP protein17155929
D003300CopperEdetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]16595185
D003300Copper[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein16595185
D003300Copper[[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] promotes the reaction [PRNP protein binds to PRNP protein]16595185
D003300CopperPRNP protein affects the reaction [Copper results in increased nitrosation of GPC1 protein]18717736
D003300CopperPRNP protein binds to Copper12500977|1659518
D003300Copper[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] promotes the reaction [PRNP protein binds to PRNP protein]16595185
D003300Copper[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein16595185
D003300Copper[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]16595185
D003300CopperPRNP protein results in decreased susceptibility to Copper12500977|1678742
D003300CopperCopper binds to and affects the folding of PRNP protein polymorphism16777497
D003300Copper[Copper binds to PRNP protein polymorphism] which binds to thioflavin T16777497
D003300CopperCopper results in increased degradation of PRNP protein16640559
D003300CopperPhosphatidylinositols promotes the reaction [Copper results in increased degradation of PRNP protein]16640559
D003300CopperPRNP protein results in increased reduction of Copper16640559
D003300CopperCopper deficiency results in increased expression of PRNP mRNA22362149
D003300CopperCopper deficiency results in increased expression of PRNP protein22362149
D003300CopperCopper results in increased expression of PRNP mRNA22465980
D003300CopperPRNP protein results in increased uptake of Copper19957168|2236214
D003300Copper[PRNP protein results in increased uptake of Copper] which results in increased activity of SOD1 protein22362149
D003300CopperCopper results in increased activity of PRNP protein22307640
D003300Copper[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein16595185
D003300CopperCopper affects the activity of PRNP protein22310309
D003300CopperCopper affects the folding of PRNP protein14519758
D003300CopperCopper affects the localization of and affects the degradation of PRNP protein16545469
D003300CopperCopper affects the reaction [Urea affects the folding of PRNP protein]21619885
D003300CopperCopper binds to and affects the folding of PRNP protein21619885
D003300CopperCopper binds to PRNP protein14706620|1692552
D003300CopperCopper binds to PRNP protein alternative form15722047
D003300Copper[Copper binds to PRNP protein alternative form] promotes the reaction [PRNP protein alternative form binds to PRNP protein alternative form]15722047
D003300Copper[Copper co-treated with PRNP protein] results in increased degradation of [GPC1 protein binds to Heparitin Sulfate]12732622
D003300CopperPRNP protein affects the uptake of Copper21265952
D003300CopperPRNP protein binds to and affects the oxidation of Copper19585160
D003300CopperPRNP protein binds to and results in decreased activity of Copper17059225
D003300CopperPRNP protein binds to Copper12482851|1257266
D003300Copper[Zinc binds to PRNP protein] inhibits the reaction [Copper binds to PRNP protein]21710304
D019327Copper SulfateCopper Sulfate results in increased expression of PRNP mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased uptake of and affects the localization of PRNP protein11994310
D019327Copper SulfateFilipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D019327Copper SulfateNystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D019327Copper SulfatePRNP protein binds to Copper Sulfate16847141
D019327Copper SulfatePRNP protein polymorphism binds to Copper Sulfate16847141
D019327Copper SulfateCopper Sulfate results in increased uptake of and affects the localization of PRNP protein11994310
D019327Copper SulfateFilipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D019327Copper SulfateNystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D019327Copper SulfatePRNP protein binds to Copper Sulfate16787422
D019327Copper SulfatePRNP protein results in decreased susceptibility to Copper Sulfate16787422
D019327Copper SulfateCopper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]14713301
D019327Copper SulfateGlutathione inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]14713301
D019327Copper SulfateTXN protein inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]14713301
C029892cupric chloride[NADP co-treated with cupric chloride] promotes the reaction [PRNP protein binds to PRNP protein]16990274
C029892cupric chloridecupric chloride affects the folding of PRNP protein16855791
C029892cupric chloridebathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein]16148034
C029892cupric chloridecupric chloride results in increased expression of PRNP mRNA16148034
C029892cupric chloridecupric chloride results in increased expression of PRNP protein16148034
D016572CyclosporineCyclosporine results in increased expression of PRNP mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of PRNP mRNA19770486
D003561CytarabineCytarabine results in decreased expression of PRNP mRNA21198554
D003671DEET[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRNP mRNA28659758
D002945CisplatinPRNP protein results in decreased susceptibility to Cisplatin15386405
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRNP mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of PRNP mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PRNP mRNA25380136
D0150601,2-Dipalmitoylphosphatidylcholine"1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form"20936829
D0150601,2-Dipalmitoylphosphatidylcholine"Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form]"20936829
D004050DitiocarbDitiocarb results in increased expression of PRNP protein20452388
D004237DiuronDiuron metabolite results in decreased expression of PRNP mRNA24172598
D004317DoxorubicinPRNP protein results in decreased susceptibility to Doxorubicin15386405
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of PRNP mRNA"23811387
D004492Edetic AcidEdetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]16595185
D004492Edetic AcidEdetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]16595185
C118739entinostatentinostat results in increased expression of PRNP mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
D000431EthanolEthanol results in increased expression of PRNP mRNA28069986
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRNP mRNA12075121
C004912ethylbenzeneethylbenzene results in increased expression of PRNP mRNA20359517
C024565ethylene dichlorideethylene dichloride results in decreased expression of PRNP mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PRNP mRNA23649840
D005047EtoposidePRNP protein results in decreased susceptibility to Etoposide15386405
D005372FilipinFilipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D005372FilipinFilipin results in increased secretion of PRNP protein11994310
D005372Filipin[Copper co-treated with Filipin] results in increased cleavage of PRNP protein19597535
D005372FilipinFilipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D005372FilipinFilipin results in decreased expression of PRNP protein alternative form11994310
D005372FilipinFilipin results in increased secretion of PRNP protein11994310
D005472FluorouracilPRNP protein results in decreased susceptibility to Fluorouracil15386405
D005485FlutamideFlutamide results in increased expression of PRNP mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of PRNP mRNA23649840
C039281furanfuran results in increased expression of PRNP mRNA27387713
D019833GenisteinGenistein results in increased expression of PRNP mRNA18444173
D019833GenisteinGenistein results in decreased expression of PRNP mRNA24967385
D019833GenisteinGenistein results in increased expression of PRNP mRNA12075121
D005839GentamicinsGentamicins results in decreased expression of PRNP mRNA22061828
D005947Glucose[PRNP protein results in increased expression of SLC2A1 protein] which results in increased uptake of Glucose21265952
D005978GlutathionePRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione]17483122
D005978GlutathioneGlutathione inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]14713301
D006497Heparitin SulfatePRNP protein modified form binds to Heparitin Sulfate metabolite18717736
D006497Heparitin Sulfate[Copper co-treated with PRNP protein] results in increased degradation of [GPC1 protein binds to Heparitin Sulfate]12732622
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein16595185
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PRNP mRNA12419474
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]16595185
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]16595185
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]16595185
D006861Hydrogen PeroxideEdetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]16595185
D006861Hydrogen PeroxideEdetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]16595185
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein16595185
D006861Hydrogen Peroxide[[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein] promotes the reaction [PRNP protein binds to PRNP protein]16595185
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein16595185
D006861Hydrogen Peroxide[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] promotes the reaction [PRNP protein binds to PRNP protein]16595185
D006861Hydrogen Peroxide[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein16595185
D006861Hydrogen Peroxide[[PRNP protein binds to Copper] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]16595185
D006861Hydrogen Peroxide[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein16595185
D006861Hydrogen Peroxide[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]16595185
D006861Hydrogen PeroxidePRNP protein results in decreased susceptibility to Hydrogen Peroxide17483122
D006861Hydrogen PeroxidePRNP protein results in increased susceptibility to Hydrogen Peroxide12500977
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein16595185
C492448ICG 001ICG 001 results in increased expression of PRNP mRNA26191083
D007501IronEdetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein]16595185
D007501Iron[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein16595185
D007501Iron"Iron, Dietary inhibits the reaction [PRNP gene mutant form results in decreased abundance of Iron]"23478311
D007501IronPRNP gene mutant form results in decreased abundance of Iron23478311
D019266Iron, Dietary"Iron, Dietary inhibits the reaction [PRNP gene mutant form results in decreased abundance of Iron]"23478311
C410337K 7174K 7174 results in increased expression of PRNP mRNA24086573
D048628KetolidesKetolides analog results in increased expression of PRNP mRNA24967691
D007854LeadLead affects the expression of PRNP mRNA28903495
C029433lead tetraacetatelead tetraacetate results in decreased expression of PRNP mRNA20865013
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PRNP mRNA19339665
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of PRNP mRNA]19339665
D008345ManganeseCAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]16595185
D008345ManganeseManganese results in increased stability of PRNP protein20176619
D008345ManganesePRNP protein binds to Manganese16595185
D008345Manganese[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of PRNP protein16595185
D008345Manganese[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]16595185
C025340manganese chloridePRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione]17483122
C025340manganese chloridePRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP3 protein]17483122
C025340manganese chloridePRNP protein inhibits the reaction [manganese chloride results in increased activity of CASP9 protein]17483122
C025340manganese chloridePRNP protein inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]17483122
C025340manganese chloridePRNP protein results in decreased susceptibility to manganese chloride17483122
C042720mercuric bromidemercuric bromide results in increased expression of PRNP mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
D008727MethotrexateMethotrexate results in decreased expression of PRNP mRNA17400583
C005219methyl cellosolvemethyl cellosolve results in increased expression of PRNP mRNA21061450
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of PRNP mRNA]19339665
D008752Methylene ChlorideMethylene Chloride results in increased expression of PRNP mRNA20359517
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PRNP protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PRNP mRNA28001369
D008767Methylmercury Compounds[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of PRNP mRNA20020106
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PRNP mRNA23649840
C008493methylselenic acidmethylselenic acid results in increased expression of PRNP mRNA18548127
D016685MitomycinMitomycin results in increased expression of PRNP mRNA12760830
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PRNP mRNA23360888
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PRNP mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of PRNP mRNA23811387
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of PRNP mRNA25380136
D009532NickelNickel binds to PRNP protein17126907
D009532NickelNickel inhibits the reaction [PRNP protein binds to PRNP protein]16595185
D009532NickelNickel binds to PRNP protein alternative form15722047
C029938nickel sulfatenickel sulfate results in decreased expression of PRNP mRNA22714537
D009599Nitroprusside[Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of PRNP mRNA12393473
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of PRNP mRNA17616710
C504137nitrosonium ion[Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of PRNP mRNA12393473
D009761NystatinNystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
D009761NystatinNystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]11994310
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PRNP mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PRNP mRNA25729387
D010100Oxygen2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA]17387271
D010100OxygenOxygen deficiency results in increased expression of PRNP mRNA17387271
D010100OxygenOxygen deficiency results in increased expression of PRNP protein17387271
D010100OxygenOxygen deficiency results in increased expression of PRNP mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of PRNP mRNA]22629407
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PRNP mRNA26272509
C016030pantogabpantogab results in decreased expression of PRNP mRNA17379144
D010269ParaquatPRNP protein results in decreased susceptibility to Paraquat15451062|1789679
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of PRNP mRNA23602845
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PRNP mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PRNP protein26879310
D026023Permethrin[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRNP mRNA28659758
D030421Peroxynitrous AcidAcetylcysteine inhibits the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]14713301
D030421Peroxynitrous AcidCopper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]14713301
D030421Peroxynitrous AcidGlutathione inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]14713301
D030421Peroxynitrous AcidPeroxynitrous Acid results in decreased activity of PRNP protein14713301
D030421Peroxynitrous AcidPyruvic Acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]14713301
D030421Peroxynitrous AcidTXN protein inhibits the reaction [Copper Sulfate affects the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]]14713301
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRNP mRNA26272509
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD1 protein]20806394
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [PRNP protein alternative form results in decreased activity of SOD2 protein]20806394
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [PRNP protein alternative form results in increased activity of CASP3 protein]20806394
D010716PhosphatidylinositolsPhosphatidylinositols promotes the reaction [Copper results in increased degradation of PRNP protein]16640559
D010716PhosphatidylinositolsPhosphatidylinositols promotes the reaction [PRNP protein binds to PRNP protein]16640559
D010795Phthalic AcidsPhthalic Acids results in increased expression of PRNP mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of PRNP mRNA17426115|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of PRNP mRNA23557933
D011078Polychlorinated Biphenyls[Methylmercury Compounds co-treated with Polychlorinated Biphenyls] results in increased expression of PRNP mRNA20020106
D011374ProgesteroneProgesterone results in increased expression of PRNP mRNA18037150
D011374ProgesteroneProgesterone results in increased expression of PRNP mRNA19690047
D011729Pyridostigmine Bromide[Pyridostigmine Bromide co-treated with DEET co-treated with Permethrin] results in increased expression of PRNP mRNA28659758
D019289Pyruvic AcidPyruvic Acid inhibits the reaction [Peroxynitrous Acid results in decreased activity of PRNP protein]14713301
D017382Reactive Oxygen Species[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species19697239
D017382Reactive Oxygen Species[[[Copper binds to PRNP protein] which results in increased reduction of Copper] which results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of PRNP protein19697239
D017382Reactive Oxygen SpeciesPRNP protein inhibits the reaction [manganese chloride results in increased chemical synthesis of Reactive Oxygen Species]17483122
D012834SilverSilver results in increased expression of PRNP mRNA26551752
D012834SilverSilver affects the expression of PRNP mRNA19429238
C017947sodium arsenitesodium arsenite affects the expression of PRNP mRNA29319823
C017947sodium arsenitesodium arsenite results in decreased expression of PRNP mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of PRNP mRNA12760830|2822993
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate affects the folding of PRNP protein modified form20936829
D053260SootSoot results in increased expression of PRNP mRNA21914721
C061133tamibarotenetamibarotene affects the expression of PRNP mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRNP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PRNP mRNA17942748
D013752TetracyclineTetracycline binds to PRNP protein10903871
D013752TetracyclineTetracycline inhibits the reaction [PRNP protein binds to PRNP protein]10903871
D013853ThioacetamideThioacetamide results in increased expression of PRNP mRNA23411599
C009462thioflavin T[Copper binds to PRNP protein polymorphism] which binds to thioflavin T16777497
C009462thioflavin Tthioflavin T binds to PRNP protein16777497
C009462thioflavin Tthioflavin T binds to PRNP protein polymorphism16777497
C009462thioflavin T[Zinc binds to PRNP protein polymorphism] which binds to thioflavin T16777497
D014050TolueneToluene results in increased expression of PRNP mRNA20359517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PRNP mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PRNP mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PRNP mRNA15498508
D014212TretinoinTretinoin results in increased expression of PRNP mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of PRNP mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of PRNP mRNA20359517
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PRNP mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PRNP mRNA24935251|2627250
D014266TrientinePRNP protein affects the susceptibility to Trientine22362149
D014266TrientineTrientine results in increased expression of PRNP mRNA22362149
D014266TrientineTrientine results in increased expression of PRNP protein22362149
D014270TrifluoroethanolTrifluoroethanol affects the folding of PRNP protein modified form20936829
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PRNP mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of PRNP mRNA22378314
D014508UreaCopper affects the reaction [Urea affects the folding of PRNP protein]21619885
D014508UreaUrea affects the folding of PRNP protein21619885
D014520UrethaneUrethane results in increased expression of PRNP mRNA28818685
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of PRNP mRNA15885361
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRNP mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PRNP mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRNP gene25560391
D014750VincristinePRNP protein results in decreased susceptibility to Vincristine15386405
D015032ZincPRNP protein affects the localization of Zinc19486831
D015032ZincPRNP protein results in decreased susceptibility to Zinc19486831
D015032ZincZinc binds to PRNP protein polymorphism16777497
D015032Zinc[Zinc binds to PRNP protein polymorphism] which binds to thioflavin T16777497
D015032ZincZinc binds to PRNP protein21710304
D015032ZincZinc binds to PRNP protein alternative form15722047
D015032Zinc[Zinc binds to PRNP protein] inhibits the reaction [Copper binds to PRNP protein]21710304
D015034Zinc OxideZinc Oxide results in increased expression of PRNP mRNA19755143

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001540amyloid-beta binding-IDA24012003  
GO:0001540amyloid-beta binding-IPI22820466  
GO:0001540amyloid-beta binding-ISS-  
GO:0001540amyloid-beta binding-TAS21593310  
GO:0002020protease binding-ISS-  
GO:0005507copper ion binding-IDA11900542  
GO:0005507copper ion binding-TAS16294306  19242475  24970228  
GO:0005515protein binding-IPI16286452  18482256  21920025  22285492  22484317  23236467  
23907583  24028865  
GO:0005521lamin binding-IEA-  
GO:0005539glycosaminoglycan binding-ISS-  
GO:0008017microtubule binding-IDA16004966  
GO:0015631tubulin binding-IDA16004966  
GO:0031802type 5 metabotropic glutamate receptor binding-IPI24012003  
GO:0031802type 5 metabotropic glutamate receptor binding-ISS-  
GO:0031805type 8 metabotropic glutamate receptor bindingNOTIDA24012003  
GO:0038023signaling receptor activity-ISS-  
GO:0042802identical protein binding-IMP20564047  
GO:0042802identical protein binding-IPI16286452  18025469  18436646  19204296  19278656  19927125  
21920025  
GO:0043008ATP-dependent protein binding-IEA-  
GO:0044325ion channel binding-IEA-  
GO:0044877protein-containing complex binding-IPI23386614  
GO:0044877protein-containing complex binding-ISS-  
GO:0051087chaperone binding-IEA-  
GO:1903135cupric ion binding-IEA-  
GO:1903136cuprous ion binding-IMP20564047  
GO ID GO Term Qualifier Evidence PubMed
GO:0001933negative regulation of protein phosphorylation-ISS-  
GO:0006878cellular copper ion homeostasis-NAS16004966  
GO:0006979response to oxidative stress-ISS-  
GO:0007050cell cycle arrest-IEA-  
GO:0007611learning or memory-ISS-  
GO:0007616long-term memory-TAS19242475  
GO:0010955negative regulation of protein processing-TAS23386614  
GO:0031648protein destabilization-IMP20564047  
GO:0032147activation of protein kinase activity-IEA-  
GO:0032689negative regulation of interferon-gamma production-ISS-  
GO:0032700negative regulation of interleukin-17 production-ISS-  
GO:0032703negative regulation of interleukin-2 production-ISS-  
GO:0035584calcium-mediated signaling using intracellular calcium source-IGI24012003  
GO:0035690cellular response to drug-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0043433negative regulation of DNA-binding transcription factor activity-ISS-  
GO:0043525positive regulation of neuron apoptotic process-IMP20564047  
GO:0046007negative regulation of activated T cell proliferation-ISS-  
GO:0046686response to cadmium ion-IEA-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA22820466  
GO:0050860negative regulation of T cell receptor signaling pathway-ISS-  
GO:0051260protein homooligomerization-IMP20564047  
GO:0061098positive regulation of protein tyrosine kinase activity-IGI24012003  
GO:0070885negative regulation of calcineurin-NFAT signaling cascade-ISS-  
GO:0071280cellular response to copper ion-IDA16254249  
GO:0090314positive regulation of protein targeting to membrane-ISS-  
GO:0090647modulation of age-related behavioral decline-ISS-  
GO:0097062dendritic spine maintenance-TAS25707991  
GO:1900272negative regulation of long-term synaptic potentiation-IEA-  
GO:1900449regulation of glutamate receptor signaling pathway-ISS-  
GO:1901216positive regulation of neuron death-ISS-  
GO:1901379regulation of potassium ion transmembrane transport-IEA-  
GO:1902430negative regulation of amyloid-beta formation-ISS-  
GO:1902938regulation of intracellular calcium activated chloride channel activity-IGI24012003  
GO:1902951negative regulation of dendritic spine maintenance-ISS-  
GO:1902992negative regulation of amyloid precursor protein catabolic process-ISS-  
GO:1903078positive regulation of protein localization to plasma membrane-IEA-  
GO:1904645response to amyloid-beta-ISS-  
GO:1904646cellular response to amyloid-beta-IGI24012003  
GO:1905664regulation of calcium ion import across plasma membrane-ISS-  
GO:1990535neuron projection maintenance-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS16004966  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005794Golgi apparatus-ISS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA16254249  18419754  
GO:0005886plasma membrane-ISS-  
GO:0009986cell surface-HDA19581412  
GO:0009986cell surface-IDA18419754  
GO:0014069postsynaptic density-ISS-  
GO:0014069postsynaptic density-TAS22820466  
GO:0016234inclusion body-IMP20564047  
GO:0019898extrinsic component of membrane-TAS16004966  
GO:0030425dendritecolocalizes_withIDA24012003  
GO:0031362anchored component of external side of plasma membrane-NAS22293988  
GO:0031965nuclear membrane-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0045121membrane raft-IDA16254249  
GO:0045121membrane raft-IMP23386614  
GO:0045121membrane raft-ISS-  
GO:0070062extracellular exosome-HDA19056867  
GO:0098794postsynapse-TAS26224839  
KEGG ID KEGG Term
hsa05020Prion diseases
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20592456Lack of association between PRNP M129V polymorphism and multiple sclerosis, mild cognitive impairment, alcoholism and schizophrenia in a Korean population. (2010)Choi IGDis Markers