Gene: PSPN

5623
PSP
persephin
protein-coding
19p13.3
Ensembl:ENSG00000125650 MIM:602921 Vega:OTTHUMG00000168086 UniprotKB:O60542
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.431e-1 (AD)  6.336e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM810.82
TRAF20.819
DEDD20.817
RBM40.814
STIP10.795
AHSA10.793
JDP20.79
SLC25A420.779
RCE10.779
NR2F60.779

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRCC1-0.483
CDNF-0.48
KLRF1-0.457
RMDN1-0.446
CCDC141-0.443
KLRB1-0.441
CTSO-0.439
DPH6-0.437
CCT6B-0.437
CEACAM3-0.432

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PSPN mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of PSPN mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PSPN mRNA16483693
D001151ArsenicArsenic affects the expression of PSPN protein24675094
C095105bexarotenebexarotene results in increased expression of PSPN mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of PSPN mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of PSPN promoter22457795
D002994ClofibrateClofibrate results in decreased expression of PSPN mRNA17585979
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of PSPN mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of PSPN mRNA19549813
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of PSPN mRNA24690739
D004726EndosulfanEndosulfan results in increased expression of PSPN mRNA26615145
C024565ethylene dichlorideethylene dichloride results in increased expression of PSPN mRNA28189721
C069837fullerene C60fullerene C60 results in decreased expression of PSPN mRNA19167457
C028007nickel monoxidenickel monoxide results in decreased expression of PSPN mRNA19167457
D010936Plant ExtractsPlant Extracts results in decreased expression of PSPN mRNA23557933
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PSPN mRNA29024780
D014520UrethaneUrethane results in increased expression of PSPN mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of PSPN gene29154799
D014635Valproic AcidValproic Acid affects the expression of PSPN mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005102signaling receptor binding-TAS9491986  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0007399nervous system development-TAS9491986  
GO:0007411axon guidance-TAS-  
GO:0007417central nervous system development-TAS9491986  
GO:0010469regulation of signaling receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-419037NCAM1 interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-8853659RET signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25975578The RET fusion gene and its correlation with demographic and clinicopathological features of non-small cell lung cancer: a meta-analysis. (2015)Lin CCancer Biol Ther