Gene: PROC

5624
APC|PC|PROC1|THPH3|THPH4
protein C, inactivator of coagulation factors Va and VIIIa
protein-coding
2q14.3
Ensembl:ENSG00000115718 MIM:612283 Vega:OTTHUMG00000131528 UniprotKB:P04070
NG_016323.1
PubMed
0   ANCO-SNPs
ND|AD
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.542e-1 (AD)  2.211e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F0.645
WDR540.626
VAT1L0.622
MESP20.622
MYADML20.621
ORAI20.616
KDM80.613
RAP1GAP0.611
PDZD70.611
GPR1500.61

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C4orf19-0.381
EPS8-0.381
PCDH18-0.374
ZIC5-0.372
ADRB2-0.365
MAML2-0.363
ARHGAP42-0.36
EBF1-0.358
AJUBA-0.351
YES1-0.349

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00170MenadioneSmall Molecule58-27-5Approved|NutraceuticalTarget
DB00464Sodium Tetradecyl SulfateSmall Molecule139-88-8Approved|InvestigationalTarget
DB09131Cupric ChlorideSmall Molecule7447-39-4Approved|InvestigationalTarget
DB09332KappadioneSmall Molecule131-13-5ApprovedTarget
DB13149Protein S humanBiotechDrugApprovedTarget
DB00025Antihemophilic factor, human recombinantBiotechDrug139076-62-3Approved|InvestigationalEnzyme
DB13192Antihemophilic factor humanBiotechDrugApprovedEnzyme
DB13998Lonoctocog alfaBiotechDrug1388129-63-2Approved|InvestigationalEnzyme
DB13999Moroctocog alfaBiotechDrug284036-24-4ApprovedEnzyme
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PROC mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROC mRNA"27188386
C0175324-methylumbelliferylguanidinobenzoateCesium binds to and promotes the reaction [[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin]3793723
C0175324-methylumbelliferylguanidinobenzoate[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin3793723
C0175324-methylumbelliferylguanidinobenzoateSodium binds to and promotes the reaction [[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin]3793723
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROC mRNA"27188386
C0509197-hydroxy-3-methylcoumarinCesium binds to and promotes the reaction [[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin]3793723
C0509197-hydroxy-3-methylcoumarin[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin3793723
C0509197-hydroxy-3-methylcoumarinSodium binds to and promotes the reaction [[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin]3793723
D000082AcetaminophenAcetaminophen results in decreased expression of PROC mRNA27761495
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PROC protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PROC mRNA22100608|2715375
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PROC mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of PROC mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PROC mRNA16483693
C431583aspartyl-alanyl-histidyl-lysineaspartyl-alanyl-histidyl-lysine inhibits the reaction [cupric chloride results in decreased activity of PROC protein]11820775
C431583aspartyl-alanyl-histidyl-lysineaspartyl-alanyl-histidyl-lysine results in increased activity of PROC protein11820775
D001553BenzbromaroneBenzbromarone affects the expression of PROC mRNA19483382
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PROC mRNA17905399
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PROC mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PROC mRNA20504355
D004958EstradiolEstradiol results in increased expression of PROC mRNA23557687
D004958EstradiolEstradiol results in decreased expression of PROC protein12730085
C006780bisphenol Abisphenol A affects the expression of PROC mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PROC mRNA25181051
D002104Cadmium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of PROC mRNA21481475
D019256Cadmium ChlorideCadmium Chloride affects the expression of PROC mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of PROC mRNA22110744
D002586CesiumCesium binds to and promotes the reaction [[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin]3793723
D002994ClofibrateClofibrate affects the expression of PROC mRNA16081524
D002994ClofibrateClofibrate results in decreased expression of PROC mRNA17585979
D002994ClofibrateClofibrate affects the expression of PROC mRNA19483382
D002997ClomipramineClomipramine results in increased expression of PROC protein17891354
D003024ClozapineClozapine results in increased expression of PROC protein20126316
C044626CMF protocolCMF protocol results in decreased expression of PROC protein8879681
C018021cobaltous chloridecobaltous chloride results in decreased expression of PROC mRNA24386269
D003276Contraceptives, Oral"Contraceptives, Oral affects the activity of PROC protein"9136971
D003276Contraceptives, Oral"Contraceptives, Oral results in decreased expression of PROC"15185533
D003276Contraceptives, Oral"PROC protein affects the susceptibility to Contraceptives, Oral"8967151
D003300CopperCopper results in decreased expression of PROC mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of PROC mRNA19549813
C029892cupric chlorideALB protein inhibits the reaction [cupric chloride results in decreased activity of PROC protein]11820775
C029892cupric chlorideaspartyl-alanyl-histidyl-lysine inhibits the reaction [cupric chloride results in decreased activity of PROC protein]11820775
C029892cupric chloridecupric chloride binds to and results in decreased activity of PROC protein11820775
C034528CycloProveraCycloProvera results in decreased expression of PROC protein14561536
D016572CyclosporineCyclosporine affects the expression of PROC mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of PROC mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of PROC protein2859508
D013759DronabinolDronabinol results in decreased expression of PROC mRNA16616335
D017135DesogestrelDesogestrel results in decreased activity of PROC protein11301170
D002945CisplatinCisplatin results in decreased expression of PROC protein10475134
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein15288212
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PROC mRNA19638242
D004317DoxorubicinDoxorubicin affects the metabolism of PROC protein17172434
C418365estradiol, norethindrone drug combination"estradiol, norethindrone drug combination results in decreased expression of PROC protein"14561536
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased activity of PROC protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC protein14561536
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in increased activity of PROC protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in increased activity of PROC protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC protein11720199
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC protein11994571
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC15669648
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PROC protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PROC protein12618251|1455114
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PROC protein12618251
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination affects the activity of PROC protein10636369
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in decreased expression of PROC protein15318540
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased activity of PROC protein11994571|8908527
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of PROC protein10928463|1261825
C072593ethinyl estradiol, levonorgestrel drug combination"ethinyl estradiol, levonorgestrel drug combination affects the activity of PROC protein"10636369
D005001EthionineEthionine affects the expression of PROC mRNA19483382
D005472FluorouracilFluorouracil results in decreased activity of PROC protein2297659
D005485FlutamideFlutamide results in decreased expression of PROC mRNA24136188
D004397FonofosFonofos results in increased methylation of PROC promoter22847954
C039281furanfuran results in decreased expression of PROC mRNA25539665
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] affects the expression of PROC protein11720199
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PROC protein11994571
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC15669648
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased expression of PROC protein12618251
C033273GestodeneGestodene results in decreased activity of PROC protein11301170
C033273GestodeneGestodene results in decreased expression of PROC protein12730085
D006493HeparinHeparin deficiency results in increased activity of PROC protein7895349
D017313FenretinideFenretinide results in increased expression of PROC mRNA28973697
C544151jinfukangjinfukang results in increased expression of PROC mRNA27392435
D007840LatexLatex promotes the reaction [Lipopolysaccharides results in decreased activity of PROC protein]18938192
D008070LipopolysaccharidesLatex promotes the reaction [Lipopolysaccharides results in decreased activity of PROC protein]18938192
D008070LipopolysaccharidesLipopolysaccharides results in decreased activity of PROC protein18938192
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PROC mRNA17905399
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PROC mRNA"23845593
D009640Norethindrone[Ethinyl Estradiol binds to Norethindrone] which results in increased expression of PROC protein14561536
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in increased expression of PROC protein12618251
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PROC protein15288212
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of PROC protein12618251|1455114
C025589ochratoxin Aochratoxin A results in decreased expression of PROC mRNA29274910
D009853OmeprazoleOmeprazole affects the expression of PROC mRNA19483382
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in decreased expression of PROC mRNA24888373
D010278ParathionParathion results in increased methylation of PROC promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of PROC mRNA22178795
D052638Particulate MatterParticulate Matter results in increased expression of PROC mRNA21029357
D010433PentylenetetrazolePentylenetetrazole affects the expression of PROC mRNA21503142
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of PROC mRNA21984479
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of PROC mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of PROC mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of PROC mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PROC mRNA18804290
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROC mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of PROC mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of PROC mRNA]17950772
C006253pirinixic acidpirinixic acid affects the expression of PROC mRNA19483382
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in decreased expression of PROC mRNA24888373
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PROC mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of PROC mRNA21278054
D011441PropylthiouracilPropylthiouracil affects the expression of PROC mRNA19483382
D011794QuercetinQuercetin results in decreased expression of PROC mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased activity of PROC protein16359964
C089730rosiglitazonerosiglitazone results in decreased expression of PROC mRNA25572481
D012643Selenium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of PROC mRNA21481475
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PROC mRNA25895662
D012964SodiumSodium binds to and promotes the reaction [[PROC protein results in increased metabolism of 4-methylumbelliferylguanidinobenzoate] which results in increased abundance of 7-hydroxy-3-methylcoumarin]3793723
D013629TamoxifenTamoxifen results in decreased expression of PROC protein15850603
C012568terbufosterbufos results in increased methylation of PROC promoter22847954
C004648testosterone enanthatetestosterone enanthate results in decreased expression of PROC protein8585008
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PROC mRNA25461914
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PROC mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PROC mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PROC mRNA15644576
D013853ThioacetamideThioacetamide affects the expression of PROC mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of PROC mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of PROC mRNA23557971
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of PROC mRNA17905399
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PROC mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROC mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PROC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PROC mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of PROC mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PROC mRNA21029357
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PROC gene25560391
C030852vinorelbinevinorelbine results in decreased expression of PROC protein10475134
C029297vinylidene chloridevinylidene chloride results in decreased expression of PROC mRNA26682919
D014859WarfarinPROC gene polymorphism affects the susceptibility to Warfarin17048007|1749616
D014859WarfarinPROC protein results in increased susceptibility to Warfarin17496169
C031238zinc sulfide[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of PROC mRNA21481475

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IMP25748729  
GO:0004252serine-type endopeptidase activity-TAS15005336  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI15248212  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-IEA-  
GO:0006508proteolysis-NAS12052963  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007596blood coagulation-TAS-  
GO:0030195negative regulation of blood coagulation-IBA21873635  
GO:0030195negative regulation of blood coagulation-TAS15005336  
GO:0043066negative regulation of apoptotic process-IMP12563316  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0044537regulation of circulating fibrinogen levels-IEA-  
GO:0050728negative regulation of inflammatory response-IMP25651845  
GO:0050819negative regulation of coagulation-IMP25651845  
GO:1903142positive regulation of establishment of endothelial barrier-IMP25651845  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IDA25748729  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IDA25748729  
GO:0005796Golgi lumen-TAS-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-159740Gamma-carboxylation of protein precursorsTAS
R-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusTAS
R-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteinsTAS
R-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21571689Quitting trajectories of Chinese youth smokers following telephone smoking cessation counseling: a longitudinal study. (2011 Sep)Wong DCNicotine Tob Res
12752561Postural sway in normal subjects aged 20-70 years. (2003 May)Rogind HClin Physiol Funct Imaging
6724187Is hypoxia involved in the mechanism of alcohol-induced liver injury? (1984 Apr)Thurman RGFundam Appl Toxicol
12379456On the origin of p53 G:C --> T:A transversions in lung cancers. (2002 Oct 31)Rodin SNMutat Res
9053796Mesolimbic dopaminergic reduction outlasts ethanol withdrawal syndrome: evidence of protracted abstinence. (1996 Mar)Diana MNeuroscience
22474003Analyzing repeated measures semi-continuous data, with application to an alcohol dependence study. (2016 Feb)Liu LStat Methods Med Res
27350677Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus. (2016 Jun)Wang KSJ Genet
20545799SAS macros for point and interval estimation of area under the receiver operating characteristic curve for non-proportional and proportional hazards Weibull models. (2010 Aug)Mannan HJ Eval Clin Pract
24165215Smoking patterns, depression, and sociodemographic variables among Flemish women during pregnancy and the postpartum period. (2013 Nov-Dec)De Wilde KSNurs Res
16894595Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. (2006 Dec 5)Drgon TAm J Med Genet B Neuropsychiatr Genet
20177882Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA. (2010 Apr)LeSage MGPsychopharmacology (Berl)
16601242Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells. (2006 Sep)Reynolds PRAm J Respir Cell Mol Biol
25419096Latent Class Analysis With Distal Outcomes: A Flexible Model-Based Approach. (2013 Jan)Lanza STStruct Equ Modeling
21110013Prediction of phenprocoumon maintenance dose and phenprocoumon plasma concentration by genetic and non-genetic parameters. (2011 Apr)Geisen CEur J Clin Pharmacol
19437280Effects of polymorphic variations in tumor necrosis factor alpha and occupational exposure to grain dust on longitudinal decline in pulmonary function. (2009)Pahwa PJ Agromedicine
22547331Varenicline decreases alcohol consumption in heavy-drinking smokers. (2012 Oct)Mitchell JMPsychopharmacology (Berl)
19925977Third molars and periodontal pathologic findings in middle-age and older Americans. (2009 Dec)Moss KLJ Oral Maxillofac Surg
22519869Adult tooth loss for residents of US coal mining and Appalachian counties. (2012 Dec)Hendryx MCommunity Dent Oral Epidemiol
29257283Construction of a 26feature gene support vector machine classifier for smoking and nonsmoking lung adenocarcinoma sample classification. (2018 Feb)Yang LMol Med Rep
22529829A Practical Guide to Calculating Cohen's f(2), a Measure of Local Effect Size, from PROC MIXED. (2012)Selya ASFront Psychol