Gene: KIAA1217

56243
ETL4|SKT
KIAA1217
protein-coding
10p12.2-p12.1
Ensembl:ENSG00000120549 MIM:617367 Vega:OTTHUMG00000017824 UniprotKB:Q5T5P2
NC_000010.11
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.962e-1 (AD)  5.922e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4748949chr10:24514128 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2366915chr10:24418740 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4748908chr10:23725193 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SAMD120.933
NPTX10.933
AAK10.929
SCN3B0.928
SLITRK10.927
OPCML0.927
SV2B0.927
DOCK30.926
KIAA1549L0.925
ADD20.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.553
RHOD-0.538
COPZ2-0.531
RNF135-0.524
LRAT-0.523
MYL3-0.511
HEY2-0.511
YES1-0.51
FLT3LG-0.509
ASB4-0.507

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5388181,8-dinitro-4,5-dihydroxyanthraquinone"KIAA1217 gene SNP affects the susceptibility to 1,8-dinitro-4,5-dihydroxyanthraquinone"25622337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KIAA1217 gene27153756
D013196Dihydrotestosteronebicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of KIAA1217 mRNA]17624924
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of KIAA1217 mRNA17624924
D001280AtrazineAtrazine results in decreased expression of KIAA1217 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KIAA1217 mRNA26238291
C053541bicalutamidebicalutamide inhibits the reaction [Dihydrotestosterone results in decreased expression of KIAA1217 mRNA]17624924
C006780bisphenol Abisphenol A affects the expression of KIAA1217 mRNA25181051
C000944dicrotophosdicrotophos results in increased expression of KIAA1217 mRNA28302478
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
D000431EthanolEthanol results in increased expression of KIAA1217 mRNA28069986
D017313FenretinideFenretinide results in increased expression of KIAA1217 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of KIAA1217 mRNA17183730
C042720mercuric bromidemercuric bromide results in increased expression of KIAA1217 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
D008777MethyltestosteroneMethyltestosterone results in decreased expression of KIAA1217 mRNA29191790
C029938nickel sulfatenickel sulfate results in decreased expression of KIAA1217 mRNA22714537
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIAA1217 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KIAA1217 mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KIAA1217 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of KIAA1217 mRNA20864642
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KIAA1217 mRNA28065790
D014212TretinoinTretinoin results in increased expression of KIAA1217 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of KIAA1217 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of KIAA1217 mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of KIAA1217 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of KIAA1217 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of KIAA1217 mRNA23179753
D014638VanadatesVanadates results in increased expression of KIAA1217 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0048706embryonic skeletal system development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal