| Probe | Locus(GRCh37) | Gene | Region | p-val | Trait | PubMed ID |
| cg21075643 | chr6:32365785 | BTNL2 | 2.530e-8 | Alcohol consumption per day | 27843151 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| ANKRD36C | 0.572 |
| ANKRD26 | 0.565 |
| ZNF91 | 0.559 |
| PRSS51 | 0.558 |
| ZNF407 | 0.558 |
| ANKRD36 | 0.558 |
| MASP2 | 0.557 |
| SYN3 | 0.557 |
| ARMC2 | 0.556 |
| CACNA1D | 0.554 |
| Gene Symbol | Pearson Correlation Coefficient |
|---|---|
| HEY2 | -0.358 |
| SERTAD1 | -0.322 |
| ROM1 | -0.322 |
| EIF4EBP1 | -0.291 |
| PDZK1IP1 | -0.287 |
| RAB13 | -0.285 |
| SERTAD3 | -0.285 |
| MPST | -0.284 |
| HEBP2 | -0.283 |
| LCN9 | -0.283 |
| ID | Drug Name | Action | PubMed |
|---|---|---|---|
| D001151 | Arsenic | Arsenic affects the methylation of BTNL2 gene | 25304211 |
| C543008 | bis(4-hydroxyphenyl)sulfone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTNL2 mRNA | 28628672 |
| C006780 | bisphenol A | bisphenol A results in decreased expression of BTNL2 mRNA | 25181051 |
| D019256 | Cadmium Chloride | Cadmium Chloride results in decreased expression of BTNL2 mRNA | 18804290 |
| D003907 | Dexamethasone | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTNL2 mRNA | 28628672 |
| D017313 | Fenretinide | Fenretinide results in decreased expression of BTNL2 mRNA | 28973697 |
| D007213 | Indomethacin | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTNL2 mRNA | 28628672 |
| D015056 | 1-Methyl-3-isobutylxanthine | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of BTNL2 mRNA | 28628672 |
| D009532 | Nickel | Nickel results in decreased expression of BTNL2 mRNA | 12540486 |
| D013749 | Tetrachlorodibenzodioxin | Tetrachlorodibenzodioxin affects the expression of BTNL2 mRNA | 22574217 |
| D014212 | Tretinoin | Tretinoin results in decreased expression of BTNL2 mRNA | 23724009 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005102 | signaling receptor binding | - | IBA | 21873635 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0001817 | regulation of cytokine production | - | IBA | 21873635 |
| GO:0050776 | regulation of immune response | - | IBA | 21873635 |
| GO:0050852 | T cell receptor signaling pathway | - | IBA | 21873635 |
| GO ID | GO Term | Qualifier | Evidence | PubMed |
|---|---|---|---|---|
| GO:0005886 | plasma membrane | - | TAS | - |
| GO:0009897 | external side of plasma membrane | - | IBA | 21873635 |
| GO:0016021 | integral component of membrane | - | IEA | - |
| KEGG ID | KEGG Term |
|---|
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-HSA-1280218 | Adaptive Immune System | TAS |
| R-HSA-168256 | Immune System | TAS |
| R-HSA-8851680 | Butyrophilin (BTN) family interactions | TAS |
| PMID | Title (Year) | Author | Journal |
|---|---|---|---|
| 26272072 | An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. (2016 Jan) | Jiang X | Rheumatology (Oxford) |
| 18037811 | Genetic predisposition to respiratory diseases: infiltrative lung diseases. (2007) | Steele MP | Respiration |
| 28025329 | Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017 Jan 15) | Seow WJ | Hum Mol Genet |