Gene: MEPCE

56257
BCDIN3
methylphosphate capping enzyme
protein-coding
7q22.1
Ensembl:ENSG00000146834 MIM:611478 Vega:OTTHUMG00000155255 UniprotKB:Q7L2J0
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
4.784e-1 (AD)  1.625e-1 (ND)   (Frontal_Cortex)
7.611e-1 (AD)  3.753e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERAL10.914
TBC1D170.912
YIPF30.911
UBE2L30.91
TRIM280.909
CDIPT0.909
CLPTM10.908
SNX150.904
UBE2I0.903
RANBP30.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.765
OR4F29-0.721
TFPI2-0.335
KLRB1-0.322
CD48-0.305
IFNG-0.301
KLRF1-0.3
GZMK-0.297
C2orf83-0.294
IL18RAP-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MEPCE mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEPCE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEPCE mRNA"27188386
D001280AtrazineAtrazine results in increased expression of MEPCE mRNA25929836
D001280AtrazineAtrazine results in decreased expression of MEPCE mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MEPCE mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of MEPCE mRNA28159858
C006780bisphenol Abisphenol A results in increased expression of MEPCE mRNA24586524
C006780bisphenol Abisphenol A results in decreased methylation of MEPCE promoter27312807
C006780bisphenol Abisphenol A results in increased expression of MEPCE mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of MEPCE mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MEPCE promoter22457795
D003042CocaineCocaine results in increased expression of MEPCE mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in increased expression of MEPCE mRNA]18355967
D019327Copper SulfateCopper Sulfate results in decreased expression of MEPCE mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MEPCE mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of MEPCE mRNA19167446
D016572CyclosporineCyclosporine results in increased methylation of MEPCE promoter27989131
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MEPCE mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of MEPCE gene22964155
D004041Dietary FatsDietary Fats results in increased expression of MEPCE mRNA18042831
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MEPCE mRNA"22485181
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MEPCE protein23301498
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MEPCE mRNA26846883
C410337K 7174K 7174 results in increased expression of MEPCE mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of MEPCE mRNA16807920
C045463leflunomideleflunomide results in decreased expression of MEPCE mRNA28988120
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MEPCE mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MEPCE mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of MEPCE mRNA19167457
D000073878Palm OilPalm Oil results in increased expression of MEPCE mRNA18042831
D010416PentachlorophenolPentachlorophenol results in increased expression of MEPCE mRNA24642059
C006253pirinixic acidpirinixic acid results in increased expression of MEPCE mRNA17426115
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MEPCE mRNA21570461
D014241TrichloroethyleneTrichloroethylene affects the expression of MEPCE mRNA21135412
C012589trichostatin Atrichostatin A results in decreased expression of MEPCE mRNA24935251|2854253
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MEPCE mRNA"26179874
D014520UrethaneUrethane results in increased expression of MEPCE mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEPCE mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MEPCE mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MEPCE mRNA19101580|2208335
D014635Valproic AcidValproic Acid results in decreased methylation of MEPCE gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of MEPCE mRNA19136453
C025643vinclozolinvinclozolin results in increased expression of MEPCE mRNA23034163
C111237vorinostatvorinostat results in decreased expression of MEPCE mRNA22083351|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  22681889  
GO:0008171O-methyltransferase activity-IBA21873635  
GO:0008173RNA methyltransferase activity-IBA21873635  
GO:0008173RNA methyltransferase activity-IDA17643375  
GO:0008757S-adenosylmethionine-dependent methyltransferase activity-IDA17643375  
GO:0017069snRNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001510RNA methylation-IDA17643375  
GO:0016073snRNA metabolic process-IDA17643375  
GO:0035562negative regulation of chromatin binding-IEA-  
GO:0040031snRNA modification-IBA21873635  
GO:0040031snRNA modification-IDA17643375  
GO:1900087positive regulation of G1/S transition of mitotic cell cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics