Gene: PARD3

56288
ASIP|Baz|PAR3|PAR3alpha|PARD-3|PARD3A|PPP1R118|SE2-5L16|SE2-5LT1|SE2-5T2
par-3 family cell polarity regulator
protein-coding
10p11.22-p11.21
Ensembl:ENSG00000148498 MIM:606745 Vega:OTTHUMG00000017948 UniprotKB:Q8TEW0
NG_052602.1
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.101e-1 (AD)  5.247e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11161396chr10:34998341PARD3Gene body2.681e-5Alcohol use disorders26763658
cg25212025chr10:34602937PARD31.200e-9Smoking27651444
cg04685387chr10:34925640PARD31.600e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGAP310.891
YAP10.883
PALLD0.881
CDC14A0.878
FERMT20.875
MID10.874
MAOA0.866
LRP100.866
TRPS10.866
MRVI10.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.609
DUSP27-0.585
AGMAT-0.581
PPEF1-0.58
MCHR1-0.565
CALHM1-0.563
ADTRP-0.556
ZNF860-0.551
TRABD2A-0.542
TYRP1-0.541

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PARD3 mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of PARD3 mRNA"19095052
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PARD3 mRNA"19114083
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of PARD3 mRNA"20713471
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PARD3 mRNA"21346803
C0299552-nitrotoluene2-nitrotoluene results in increased expression of PARD3 protein22434383
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PARD3 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PARD3 mRNA16483693
D000666Amphotericin BAmphotericin B results in decreased expression of PARD3 mRNA20849824
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PARD3 mRNA24449571
D001151ArsenicArsenic affects the methylation of PARD3 gene25304211
C015001arsenitearsenite results in increased methylation of PARD3 promoter23974009
D001280AtrazineAtrazine results in increased expression of PARD3 mRNA25929836
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PARD3 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PARD3 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PARD3 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PARD3 mRNA19770486|2171566
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PARD3 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of PARD3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PARD3 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of PARD3 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of PARD3 gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARD3 mRNA28628672
C006780bisphenol Abisphenol A results in decreased methylation of PARD3 promoter27312807
C006780bisphenol Abisphenol A affects the expression of PARD3 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PARD3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PARD3 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PARD3 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PARD3 mRNA18974090
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PARD3 mRNA20360939
C018021cobaltous chloridecobaltous chloride results in decreased expression of PARD3 mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of PARD3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of PARD3 mRNA19167446
D003520CyclophosphamideCyclophosphamide results in decreased expression of PARD3 mRNA20849824
D016572CyclosporineCyclosporine results in increased expression of PARD3 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PARD3 mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARD3 mRNA28628672
D015946Ethylene DibromideEthylene Dibromide results in increased expression of PARD3 protein22434383
D002945CisplatinCisplatin results in decreased expression of PARD3 mRNA20849824
D002945CisplatinCisplatin results in decreased expression of PARD3 mRNA25270620
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PARD3 mRNA26924002
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PARD3 mRNA20360939
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PARD3 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate affects the expression of PARD3 mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PARD3 mRNA17108234
D005472FluorouracilPARD3 protein affects the susceptibility to Fluorouracil16217747
D005839GentamicinsGentamicins results in decreased expression of PARD3 mRNA20849824
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARD3 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PARD3 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PARD3 mRNA28628672
C410337K 7174K 7174 results in increased expression of PARD3 mRNA24086573
D048628KetolidesKetolides analog results in increased expression of PARD3 mRNA24967691
C045463leflunomideleflunomide results in increased expression of PARD3 mRNA28988120
D008694MethamphetamineMethamphetamine results in increased expression of PARD3 mRNA26307267
D008713MethimazoleMethimazole results in increased expression of PARD3 mRNA22504374
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PARD3 mRNA23649840
C028577monobutyl phthalatemonobutyl phthalate affects the expression of PARD3 mRNA20864626
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PARD3 mRNA26924002
D009151Mustard GasMustard Gas affects the expression of PARD3 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PARD3 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of PARD3 mRNA24768652|2558310
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of PARD3 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of PARD3 mRNA23091169
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PARD3 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of PARD3 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of PARD3 mRNA22504374|2478091
D012999SomanSoman results in increased expression of PARD3 mRNA19281266
C004648testosterone enanthatetestosterone enanthate affects the expression of PARD3 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PARD3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PARD3 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PARD3 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PARD3 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of PARD3 mRNA17656681
D014212TretinoinTretinoin results in increased expression of PARD3 mRNA16236135
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PARD3 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of PARD3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PARD3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PARD3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of PARD3 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PARD3 gene25560391
D014810Vitamin EVitamin E results in decreased expression of PARD3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10934474  11257119  14676191  15161933  15254234  15324660  
15782111  17057644  17353931  17979178  18838552  19893486  
22579248  22653443  24255178  25241761  26496610  26766442  
27173435  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-ISS-  
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding-ISS-  
GO:0019903protein phosphatase binding-IEA-  
GO:0032266phosphatidylinositol-3-phosphate binding-ISS-  
GO:0035091phosphatidylinositol binding-IBA21873635  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IBA21873635  
GO:0006612protein targeting to membrane-ISS-  
GO:0007049cell cycle-IEA-  
GO:0007155cell adhesion-IBA21873635  
GO:0007163establishment or maintenance of cell polarity-TAS14676191  
GO:0007179transforming growth factor beta receptor signaling pathway-TAS-  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-TAS11260256  
GO:0007409axonogenesis-TAS14676191  
GO:0008356asymmetric cell division-TAS10934474  
GO:0010801negative regulation of peptidyl-threonine phosphorylation-ISS-  
GO:0022011myelination in peripheral nervous system-ISS-  
GO:0030010establishment of cell polarity-IBA21873635  
GO:0031643positive regulation of myelination-ISS-  
GO:0045197establishment or maintenance of epithelial cell apical/basal polarity-IBA21873635  
GO:0060341regulation of cellular localization-IEA-  
GO:0065003protein-containing complex assembly-TAS10934474  
GO:0070830bicellular tight junction assembly-ISS-  
GO:0070830bicellular tight junction assembly-TAS-  
GO:0090162establishment of epithelial cell polarity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IDA20332120  
GO:0005911cell-cell junction-ISS-  
GO:0005912adherens junction-IBA21873635  
GO:0005912adherens junction-IEA-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0005923bicellular tight junction-IDA14676191  22006950  
GO:0005923bicellular tight junction-ISS-  
GO:0005938cell cortex-IBA21873635  
GO:0005938cell cortex-IEA-  
GO:0012505endomembrane system-IEA-  
GO:0016324apical plasma membrane-IBA21873635  
GO:0030054cell junction-IDA-  
GO:0030054cell junction-TAS-  
GO:0032991protein-containing complex-IEA-  
GO:0033269internode region of axon-ISS-  
GO:0043025neuronal cell body-IEA-  
GO:0043296apical junction complex-IBA21873635  
GO:0044295axonal growth cone-IEA-  
KEGG ID KEGG Term
hsa04062Chemokine signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04144Endocytosis
hsa04520Adherens junction
hsa04530Tight junction
Reactome ID Reactome Term Evidence
R-HSA-1500931Cell-Cell communicationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-170834Signaling by TGF-beta Receptor ComplexTAS
R-HSA-170834Signaling by TGF-beta Receptor ComplexIEA
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)TAS
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)IEA
R-HSA-420029Tight junction interactionsTAS
R-HSA-421270Cell-cell junction organizationTAS
R-HSA-446728Cell junction organizationTAS
R-HSA-9006936Signaling by TGF-beta family membersTAS
R-HSA-9006936Signaling by TGF-beta family membersIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal