Gene: AZGP1

563
ZA2G|ZAG
alpha-2-glycoprotein 1, zinc-binding
protein-coding
7q22.1
Ensembl:ENSG00000160862 MIM:194460 Vega:OTTHUMG00000023066 UniprotKB:P25311
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
2.381e-1 (AD)  5.210e-1 (ND)   (Frontal_Cortex)
3.044e-1 (AD)  7.034e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KIF190.736
MYOT0.692
RHOG0.675
UHRF10.667
RTKN0.647
MPST0.646
APOD0.645
EFHD10.639
ROM10.633
CDKN1C0.631

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HAPLN1-0.53
FREM3-0.521
VIP-0.51
PTHLH-0.505
FBLN7-0.5
IGF1-0.498
MARCH4-0.494
CNTN5-0.49
NXPH2-0.484
KIT-0.482

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03721N-acetyl-alpha-neuraminic acidSmall MoleculeExperimentalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C40306510-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to AZGP1 protein19539807
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AZGP1 mRNA"25510870
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of AZGP1 mRNA"17547211
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AZGP1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AZGP1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AZGP1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AZGP1 mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of AZGP1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of AZGP1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of AZGP1 mRNA27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AZGP1 mRNA16483693
D000965AntimonyAntimony results in decreased expression of AZGP1 mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of AZGP1 mRNA17547211
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of AZGP1 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of AZGP1 mRNA23912714
C006632arsenic trioxidearsenic trioxide results in decreased expression of AZGP1 mRNA17547211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of AZGP1 mRNA22316170
C006780bisphenol Abisphenol A affects the methylation of AZGP1 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of AZGP1 mRNA25181051
D002104CadmiumAZGP1 protein binds to Cadmium23896426
D002857ChromiumChromium results in decreased expression of AZGP1 mRNA17547211
C018021cobaltous chloridecobaltous chloride results in decreased expression of AZGP1 mRNA24386269
D003042CocaineCocaine results in decreased expression of AZGP1 mRNA17898221
D003300CopperAZGP1 protein binds to Copper23896426
C030123coumarincoumarin affects the expression of AZGP1 mRNA16963487
D016572CyclosporineCyclosporine results in decreased expression of AZGP1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of AZGP1 mRNA27989131
C014347decitabinedecitabine inhibits the reaction [trichostatin A results in increased expression of AZGP1 mRNA]18978557
D003907DexamethasoneDexamethasone results in increased expression of AZGP1 mRNA19853017
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AZGP1 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of AZGP1 gene22964155
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AZGP1 mRNA25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of AZGP1 promoter25374375
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AZGP1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of AZGP1 mRNA19041683|1963824
D002117CalcitriolCalcitriol results in increased expression of AZGP1 mRNA26485663
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of AZGP1 mRNA27638505
D004317DoxorubicinDoxorubicin results in decreased expression of AZGP1 mRNA16404146
D000431EthanolEthanol results in increased expression of AZGP1 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AZGP1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AZGP1 mRNA17942748
D005419FlavonoidsFlavonoids results in decreased expression of AZGP1 mRNA18035473
C039281furanfuran results in decreased expression of AZGP1 mRNA26194646
D005947GlucoseGlucose deficiency affects the secretion of AZGP1 protein24802182
D017313FenretinideFenretinide results in increased expression of AZGP1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AZGP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AZGP1 mRNA28628672
D007854LeadAZGP1 protein binds to Lead23896426
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of AZGP1 mRNA15866426
D008628MercuryMercury results in decreased expression of AZGP1 mRNA17547211
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of AZGP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AZGP1 mRNA"25554681
D009532NickelNickel results in decreased expression of AZGP1 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of AZGP1 mRNA22110744
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of AZGP1 mRNA19074003
C025589ochratoxin Aochratoxin A results in decreased expression of AZGP1 mRNA18417182
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AZGP1 mRNA"25510870
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of AZGP1 mRNA25374375
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased methylation of AZGP1 promoter25374375
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AZGP1 mRNA17547211
D011192Potassium DichromatePotassium Dichromate affects the expression of AZGP1 mRNA23608068
D015125OxyquinolineOxyquinoline results in increased expression of AZGP1 mRNA21632981
C016104sodium bichromatesodium bichromate affects the expression of AZGP1 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in increased expression of AZGP1 protein28918527
D013739TestosteroneTestosterone affects the expression of AZGP1 mRNA17003280
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of AZGP1 mRNA19074003
C010792testosterone undecanoatetestosterone undecanoate results in decreased expression of AZGP1 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of AZGP1 mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of AZGP1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AZGP1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AZGP1 mRNA18796159|2121527
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AZGP1 mRNA28943392
D013853ThioacetamideThioacetamide results in decreased expression of AZGP1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of AZGP1 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in increased expression of AZGP1 mRNA19254012
C012589trichostatin Adecitabine inhibits the reaction [trichostatin A results in increased expression of AZGP1 mRNA]18978557
C012589trichostatin Atrichostatin A results in increased expression of AZGP1 mRNA18978557
D017974Uranium CompoundsUranium Compounds results in increased expression of AZGP1 mRNA19654044
D014635Valproic AcidValproic Acid results in decreased methylation of AZGP1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of AZGP1 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004540ribonuclease activity-NAS10462714  
GO:0005515protein binding-IPI16237761  18930737  
GO:0008320protein transmembrane transporter activity-NAS6896906  
GO ID GO Term Qualifier Evidence PubMed
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IDA24248522  
GO:0001895retina homeostasis-HEP23580065  
GO:0006955immune response-IBA21873635  
GO:0007155cell adhesion-IDA9813179  
GO:0007155cell adhesion-ISS-  
GO:0008285negative regulation of cell proliferation-NAS10462714  
GO:0055085transmembrane transport-TAS-  
GO:0071806protein transmembrane transport-IEA-  
GO:0090501RNA phosphodiester bond hydrolysis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  22664934  23580065  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA24248522  
GO:0005634nucleus-HDA21630459  
GO:0005886plasma membrane-IBA21873635  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0070062extracellular exosome-HDA19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-5223345Miscellaneous transport and binding eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19188554Cigarette smoking induces overexpression of a fat-depleting gene AZGP1 in the human. (2009 May)Vanni HChest