Gene: LGMN

5641
AEP|LGMN1|PRSC1
legumain
protein-coding
14q32.12
Ensembl:ENSG00000100600 MIM:602620 Vega:OTTHUMG00000171199 UniprotKB:Q99538
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.836e-1 (AD)  6.053e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALAS10.936
LRRC590.915
TBL20.915
EFTUD20.915
VCP0.913
NEU10.911
KPNA20.909
NANS0.908
NRBP10.907
PSMC10.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.551
OR4F29-0.493
P2RY14-0.384
ASB4-0.354
CTNNA3-0.349
MTRNR2L6-0.341
MYOM1-0.326
MTRNR2L9-0.32
MTRNR2L10-0.312
C5orf64-0.31

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of LGMN mRNA"25270620
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LGMN mRNA"23146750
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LGMN mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LGMN mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of LGMN mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of LGMN mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of LGMN mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of LGMN mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LGMN mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of LGMN mRNA15725085
C547126AZM551248AZM551248 results in increased expression of LGMN mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LGMN mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of LGMN mRNA"20382639
D004958EstradiolEstradiol affects the expression of LGMN mRNA15598610
D004958EstradiolEstradiol results in increased expression of LGMN mRNA19484750
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of LGMN protein]25150618
C006780bisphenol Abisphenol A results in decreased methylation of LGMN promoter27312807
C006780bisphenol Abisphenol A results in increased expression of LGMN mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LGMN mRNA28628672
D002065BuspironeBuspirone results in decreased expression of LGMN mRNA24136188
D002104CadmiumCadmium results in increased expression of LGMN mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LGMN protein24527689
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of LGMN mRNA27339419
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of LGMN mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LGMN mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of LGMN mRNA19320972|2294125
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of LGMN protein]25150618
D003300CopperCopper deficiency affects the expression of LGMN protein25150618
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of LGMN mRNA21356183
D003300CopperCopper results in increased expression of LGMN mRNA21356183
C029892cupric chloridecupric chloride results in increased expression of LGMN mRNA19174923
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]18200517
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of LGMN mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LGMN mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LGMN mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of LGMN mRNA27392435
D004008DiclofenacDiclofenac results in increased expression of LGMN mRNA26934552
D004026DieldrinDieldrin results in decreased expression of LGMN mRNA23041725
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of LGMN mRNA17490981
D004041Dietary FatsDietary Fats results in increased expression of LGMN mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LGMN mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of LGMN mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of LGMN mRNA25380136
D004298DopamineDopamine results in increased expression of LGMN mRNA21983523
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LGMN protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of LGMN mRNA20227414
D018818FenoldopamFenoldopam results in increased expression of LGMN mRNA21983523
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LGMN mRNA20938992
D004397FonofosFonofos results in increased methylation of LGMN promoter22847954
D017313FenretinideFenretinide results in decreased expression of LGMN mRNA28973697
D007052IbuprofenIbuprofen results in increased expression of LGMN mRNA28201806
C492448ICG 001ICG 001 results in increased expression of LGMN mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LGMN mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGMN mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of LGMN mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of LGMN mRNA27392435
C544151jinfukangjinfukang results in increased expression of LGMN mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of LGMN mRNA24796395
D048628KetolidesKetolides analog results in increased expression of LGMN mRNA24967691
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of LGMN mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of LGMN mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LGMN mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LGMN mRNA23458150
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of LGMN mRNA22401849
C523799MRK 003LGMN results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of LGMN mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of LGMN mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of LGMN mRNA25380136
C028007nickel monoxidenickel monoxide results in increased expression of LGMN mRNA19167457
C012655nimesulidenimesulide results in decreased expression of LGMN mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of LGMN mRNA25729387
D010278ParathionParathion results in increased methylation of LGMN promoter22847954
D010615PhenacetinPhenacetin results in increased expression of LGMN mRNA17698508
C031181phenanthrenephenanthrene results in increased expression of LGMN mRNA19457238
C030299phenylhydrazinephenylhydrazine results in increased expression of LGMN mRNA17698508
D012402RotenoneRotenone results in decreased expression of LGMN mRNA23186747
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of LGMN mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of LGMN mRNA22431001
C016104sodium bichromatesodium bichromate results in decreased expression of LGMN mRNA17685462
D012999SomanSoman results in increased expression of LGMN mRNA19281266
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of LGMN mRNA"26680231
C012568terbufosterbufos results in increased methylation of LGMN promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of LGMN mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LGMN mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGMN mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of LGMN mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LGMN mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of LGMN mRNA28943392
C009495titanium dioxidetitanium dioxide results in increased expression of LGMN mRNA23131501|2355797
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of LGMN mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of LGMN mRNA25729387
D019772TopotecanTopotecan results in increased expression of LGMN mRNA25729387
D014212TretinoinTretinoin results in increased expression of LGMN mRNA16236135
C012589trichostatin Atrichostatin A results in increased expression of LGMN mRNA15901671
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of LGMN mRNA18200517
D014520UrethaneUrethane results in increased expression of LGMN mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of LGMN mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of LGMN mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LGMN mRNA23179753|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004197cysteine-type endopeptidase activity-IBA21873635  
GO:0004197cysteine-type endopeptidase activity-IDA9821970  18374643  22718532  25326800  
GO:0004197cysteine-type endopeptidase activity-IMP9065484  
GO:0004197cysteine-type endopeptidase activity-ISS9065484  18374643  
GO:0004197cysteine-type endopeptidase activity-TAS18377911  
GO:0008233peptidase activity-IDA136644  
GO ID GO Term Qualifier Evidence PubMed
GO:0003014renal system process-ISS-  
GO:0006508proteolysis-ISS9065484  
GO:0006624vacuolar protein processing-IBA21873635  
GO:0007613memory-ISS25326800  
GO:0008284positive regulation of cell proliferation-IMP21237226  
GO:0008306associative learning-ISS25326800  
GO:0010447response to acidic pH-IDA18374643  
GO:0010447response to acidic pH-ISS9065484  25326800  
GO:0010629negative regulation of gene expression-IMP21237226  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO:0032801receptor catabolic process-ISS-  
GO:0035729cellular response to hepatocyte growth factor stimulus-IDA21237226  
GO:0040015negative regulation of multicellular organism growth-IEA-  
GO:0042359vitamin D metabolic process-TAS-  
GO:0043524negative regulation of neuron apoptotic process-IGI18374643  
GO:0045931positive regulation of mitotic cell cycle-IMP21237226  
GO:0051603proteolysis involved in cellular protein catabolic process-IBA21873635  
GO:0051603proteolysis involved in cellular protein catabolic process-ISS-  
GO:0051603proteolysis involved in cellular protein catabolic process-TAS18377911  
GO:0071277cellular response to calcium ion-IDA21237226  
GO:0090026positive regulation of monocyte chemotaxis-IDA18377911  
GO:0097061dendritic spine organization-ISS25326800  
GO:0097202activation of cysteine-type endopeptidase activity-IDA9821970  18374643  
GO:0097264self proteolysis-IDA9821970  18374643  
GO:1900273positive regulation of long-term synaptic potentiation-ISS25326800  
GO:1901185negative regulation of ERBB signaling pathway-ISS-  
GO:1904646cellular response to amyloid-beta-IDA25326800  
GO:2001028positive regulation of endothelial cell chemotaxis-IDA18377911  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA18377911  
GO:0005737cytoplasm-IDA18377911  
GO:0005764lysosome-ISS-  
GO:0005764lysosome-TAS18377911  
GO:0005770late endosome-TAS18377911  
GO:0036021endolysosome lumen-TAS-  
GO:0043202lysosomal lumen-TAS-  
GO:0045177apical part of cell-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA21237226  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04142Lysosome
hsa04612Antigen processing and presentation
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1679131Trafficking and processing of endosomal TLRTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-196791Vitamin D (calciferol) metabolismTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27490795Six-SOMAmer Index Relating to Immune, Protease and Angiogenic Functions Predicts Progression in IPF. (2016)Ashley SLPLoS One