Gene: LTB4R2

56413
BLT2|BLTR2|JULF2|KPG_004|LTB4-R 2|LTB4-R2|NOP9
leukotriene B4 receptor 2
protein-coding
14q12
Ensembl:ENSG00000213906 MIM:605773 Vega:OTTHUMG00000186500 UniprotKB:Q9NPC1
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.126e-2 (AD)  2.534e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LTB4R0.673
FCHSD10.617
C11orf210.612
CLEC2D0.595
AIRE0.588
ZNF4310.572
BRWD30.57
CD163L10.567
MALT10.563
ZNF7000.56

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.336
RXRG-0.303
PYGM-0.3
ARSF-0.298
ROPN1B-0.291
RAB41-0.275
WFDC1-0.273
NWD1-0.273
ARSE-0.271
ASPDH-0.269

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06248AmelubantSmall Molecule346735-24-8InvestigationalTarget
DB12961Leukotriene B4Small Molecule71160-24-2InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LTB4R2 mRNA"23146750
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LTB4R2 mRNA"27291303
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of LTB4R2 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of LTB4R2 mRNA"23146750
C0315715,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid"5,12,20-trihydroxy-6,8,10,14-eicosatetraenoic acid binds to LTB4R2 protein"11006272
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LTB4R2 mRNA16483693
D001095Arachidonic AcidsArachidonic Acids binds to LTB4R2 protein11006272
C006780bisphenol Abisphenol A results in decreased expression of LTB4R2 mRNA23146750|2768578
D002211CapsaicinCapsaicin results in decreased expression of LTB4R2 mRNA16278290
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LTB4R2 gene20938992
D003300CopperCopper deficiency results in increased expression of LTB4R2 mRNA26033743
D016572CyclosporineCyclosporine results in decreased expression of LTB4R2 mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of LTB4R2 mRNA23640034|2391405
D019422Dietary SucroseDietary Sucrose results in increased expression of LTB4R2 mRNA26033743
D005419FlavonoidsFlavonoids results in increased expression of LTB4R2 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LTB4R2 gene20938992
D007975Leukotriene B4Leukotriene B4 binds to LTB4R2 protein11006272
D006893Hydroxyeicosatetraenoic AcidsHydroxyeicosatetraenoic Acids binds to LTB4R2 protein11006272
C040212leukotriene B5leukotriene B5 binds to LTB4R2 protein11006272
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of LTB4R2 gene20938992
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of LTB4R2 mRNA23146750
D010936Plant ExtractsPlant Extracts results in decreased expression of LTB4R2 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of LTB4R2 mRNA16293270
C428725pyridabenpyridaben results in decreased expression of LTB4R2 mRNA22563483
D014635Valproic AcidValproic Acid affects the expression of LTB4R2 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001631cysteinyl leukotriene receptor activity-IBA21873635  
GO:0001632leukotriene B4 receptor activity-IBA21873635  
GO:0001632leukotriene B4 receptor activity-IEA-  
GO:0004966galanin receptor activity-IBA21873635  
GO:0004974leukotriene receptor activity-TAS10889186  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-TAS10889186  
GO:0006954inflammatory response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007194negative regulation of adenylate cyclase activity-TAS10889186  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0051546keratinocyte migration-IEA-  
GO:0061737leukotriene signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10913346  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-391903Eicosanoid ligand-binding receptorsTAS
R-HSA-391906Leukotriene receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22206291The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. (2011 Dec 29)Tulah ASBMC Med Genet