Gene: PRSS1

5644
TRP1|TRY1|TRY4|TRYP1
serine protease 1
protein-coding
7q34
Ensembl:ENSG00000204983 MIM:276000 Vega:OTTHUMG00000158923 UniprotKB:P07477
NG_008307.3
PubMed
0   ANCO-SNPs
ND|AD
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.270e-1 (AD)  2.263e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPA10.981
CLPS0.969
CELA3A0.966
PNLIP0.954
CTRB10.948
CTRB20.932
GP20.912
PLA2G1B0.905
CPB10.9
CELA3B0.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSG11-0.23
TM4SF20-0.228
DNTT-0.209
CRLF2-0.203
XCR1-0.202
HMGA2-0.198
USP26-0.195
GOLGA8N-0.194
NPIPB9-0.192
AKAP4-0.191

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01665ZK-800270Small Molecule-ExperimentalTarget
DB01705Bis(5-Amidino-Benzimidazolyl)MethaneSmall MoleculeExperimentalTarget
DB017252-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideSmall MoleculeExperimentalTarget
DB01737Nalpha-(2-Naphthylsulfonylglycyl)-3-Amidino-D,L-Phenylalanine-IsopropylesterSmall Molecule133397-81-6ExperimentalTarget
DB01741CRA_17693Small MoleculeExperimentalTarget
DB01745N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)Isopipecolinic Acid Methyl EsterSmall MoleculeExperimentalTarget
DB01767Hemi-BabimSmall MoleculeExperimentalTarget
DB01771CRA_10991Small MoleculeExperimentalTarget
DB01805MonoisopropylphosphorylserineSmall MoleculeExperimentalTarget
DB01836[4-(6-Chloro-Naphthalene-2-Sulfonyl)-Piperazin-1-Yl]-(3,4,5,6-Tetrahydro-2h-[1,4']Bipyridinyl-4-Yl)-MethanoneSmall MoleculeExperimentalTarget
DB01876Bis(5-Amidino-2-Benzimidazolyl)MethanoneSmall MoleculeExperimentalTarget
DB019052-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB019395-Amidino-BenzimidazoleSmall MoleculeExperimentalTarget
DB02045AmylamineSmall Molecule110-58-7ExperimentalTarget
DB02063CRA_16847Small MoleculeExperimentalTarget
DB02081Bis-BenzamidineSmall MoleculeExperimentalTarget
DB02084CRA_17312Small MoleculeExperimentalTarget
DB02112Zk-806450Small MoleculeExperimentalTarget
DB02269[4-({[5-Benzyloxy-1-(3-Carbamimidoyl-Benzyl)-1h-Indole-2-Carbonyl]-Amino}-Methyl)-Phenyl]-Trimethyl-AmmoniumSmall MoleculeExperimentalTarget
DB022872-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB02288CRA_9334Small Molecule-ExperimentalTarget
DB023544-{[1-Methyl-5-(2-Methyl-Benzoimidazol-1-Ylmethyl)-1h-Benzoimidazol-2-Ylmethyl]-Amino}-BenzamidineSmall MoleculeExperimentalTarget
DB02366CRA_10762Small MoleculeExperimentalTarget
DB02435AminomethylcyclohexaneSmall Molecule3218-02-8ExperimentalTarget
DB024632-(2-Hydroxy-Phenyl)-1h-Indole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB02464BenzylamineSmall Molecule100-46-9ExperimentalTarget
DB02526CRA_10655Small MoleculeExperimentalTarget
DB02665(1R,2S)-2-PhenylcyclopropanaminiumSmall Molecule1986-47-6ExperimentalTarget
DB02744RPR131247Small MoleculeExperimentalTarget
DB02812(2s,4r)-1-Acetyl-N-[(1s)-4-[(Aminoiminomethyl)Amino]-1-(2-Benzothiazolylcarbonyl)Butyl]-4-Hydroxy-2-PyrrolidinecarboxamideSmall MoleculeExperimentalTarget
DB02875CRA_1802Small MoleculeExperimentalTarget
DB02989CRA_10972Small MoleculeExperimentalTarget
DB03016CRA_1801Small MoleculeExperimentalTarget
DB03081Crc200 (Chiron-Behring)Small MoleculeExperimentalTarget
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
DB031364-Iodobenzo[B]Thiophene-2-CarboxamidineSmall MoleculeExperimentalTarget
DB03159CRA_8696Small MoleculeExperimentalTarget
DB03173CRA_10433Small MoleculeExperimentalTarget
DB03213Bis(5-Amidino-2-Benzimidazolyl)Methane KetoneSmall MoleculeExperimentalTarget
DB032434-FluorobenzylamineSmall MoleculeExperimentalTarget
DB03251RWJ-51084Small MoleculeExperimentalTarget
DB033371-(2-Amidinophenyl)-3-(Phenoxyphenyl)UreaSmall MoleculeExperimentalTarget
DB03373ZK-806711Small MoleculeExperimentalTarget
DB033743,5-DiiodotyrosineSmall Molecule300-39-0ExperimentalTarget
DB034171-(4-Tert-Butylcarbamoyl-Piperazine-1-Carbonyl)-3-(3-Guanidino-Propyl)-4-Oxo-Azetidine-2-Carboxylic AcidSmall MoleculeExperimentalTarget
DB03443Bis(5-Amidino-Benzimidazolyl)Methanone ZincSmall MoleculeExperimentalTarget
DB03555CRA_11092Small MoleculeExperimentalTarget
DB03595CRA_9785Small MoleculeExperimentalTarget
DB03608DiminazeneSmall Molecule536-71-0ExperimentalTarget
DB03643CRA_1144Small MoleculeExperimentalTarget
DB038656-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB03876Thieno[2,3-B]Pyridine-2-CarboxamidineSmall Molecule-ExperimentalTarget
DB03976PhosphorylisopropaneSmall MoleculeExperimentalTarget
DB04008Bis(5-Amidino-Benzimidazolyl)Methane ZincSmall MoleculeExperimentalTarget
DB04107[(1-{2[(4-Carbamimidoyl-Phenylamino)-Methyl]-1-Methyl-1h-Benzoimidazol-5-Yl}-Cyclopropyl)-Pyridin-2-Yl-Methyleneaminooxy]-Acetic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB04125N-Alpha-(2-Naphthylsulfonyl)-N(3-Amidino-L-Phenylalaninyl)-4-Acetyl-PiperazineSmall MoleculeExperimentalTarget
DB04215CRA_9076Small MoleculeExperimentalTarget
DB04238N-Alpha-(2-Naphthylsulfonyl)-N-(3-Amidino-L-Phenylalaninyl)-D-Pipecolinic AcidSmall MoleculeExperimentalTarget
DB04246CRA_23653Small MoleculeExperimentalTarget
DB04269Cyclotheonamide ASmall Molecule129033-04-1ExperimentalTarget
DB04301Bis(5-Amidino-2-Benzimidazolyl)Methane Ketone HydrateSmall MoleculeExperimentalTarget
DB043114-PhenylbutylamineSmall MoleculeExperimentalTarget
DB04325PhenethylamineSmall Molecule64-04-0ExperimentalTarget
DB043361-(4-Amidinophenyl)-3-(4-Chlorophenyl)UreaSmall MoleculeExperimentalTarget
DB04391Aeruginosin 98-BSmall MoleculeExperimentalTarget
DB044103-PhenylpropylamineSmall Molecule2038-57-5ExperimentalTarget
DB04424RPR128515Small MoleculeExperimentalTarget
DB04432ZK-805623Small MoleculeExperimentalTarget
DB044422-(2-Oxo-1,2-Dihydro-Pyridin-3-Yl)-1h-Benzoimidazole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB04446Benzo[B]Thiophene-2-CarboxamidineSmall MoleculeExperimentalTarget
DB04470CRA_10656Small MoleculeExperimentalTarget
DB04563CRA_9678Small MoleculeExperimentalTarget
DB046544-PIPERIDIN-4-YLBUTANALSmall MoleculeExperimentalTarget
DB047902,5-bis-o-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-d-glucitolSmall Molecule-ExperimentalTarget
DB047912-O-(4'-AMIDINOPHENYL)-5-O-(3''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOLSmall MoleculeExperimentalTarget
DB047922,5-O,O-BIS-{4',4''-AMIDINOPHENYL}-1,4:3,6-DIANHYDRO-D-SORBITOLSmall MoleculeExperimentalTarget
DB047931,4:3,6-Dianhydro-2-O-(3-carbamimidoylphenyl)-5-O-(4-carbamimidoylphenyl)-D-glucitolSmall MoleculeExperimentalTarget
DB06692AprotininBiotechDrug9087-70-1Approved|Investigational|WithdrawnTarget
DB06840diethyl [(1R)-1,5-diaminopentyl]boronateSmall MoleculeExperimentalTarget
DB06845(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeExperimentalTarget
DB06850(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeExperimentalTarget
DB06853N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideSmall MoleculeExperimentalTarget
DB068556-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineSmall MoleculeExperimentalTarget
DB06858N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamideSmall MoleculeExperimentalTarget
DB069182-(2-METHYLPHENYL)-1H-INDOLE-6-CARBOXIMIDAMIDESmall MoleculeExperimentalTarget
DB069232-(3-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDESmall MoleculeExperimentalTarget
DB07088(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeExperimentalTarget
DB07091(S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamideSmall MoleculeExperimentalTarget
DB07095(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamideSmall MoleculeExperimentalTarget
DB07131(S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamideSmall MoleculeExperimentalTarget
DB072293-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-5-METHOXY-1,1'-BIPHENYL-2-OLATESmall MoleculeExperimentalTarget
DB073684-(METHYLSULFONYL)BENZENECARBOXIMIDAMIDESmall MoleculeExperimentalTarget
DB074915-amino-2,4,6-tribromobenzene-1,3-dicarboxylic acidSmall MoleculeExperimentalTarget
DB07985+/-METHYL 4-(AMINOIMINOMETHYL)-BETA-[3- INH (AMINOIMINO)PHENYL]BENZENE PENTANOATESmall MoleculeExperimentalTarget
DB081842-(2-METHYLPHENYL)-1H-INDOLE-5-CARBOXIMIDAMIDESmall MoleculeExperimentalTarget
DB082542-NAPHTHALENESULFONIC ACIDSmall MoleculeExperimentalTarget
DB084201-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACIDSmall MoleculeExperimentalTarget
DB08763[N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATESmall MoleculeExperimentalTarget
DB12598NafamostatSmall Molecule81525-10-2Approved|InvestigationalTarget
DB12831GabexateSmall Molecule39492-01-8InvestigationalEnzyme
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of PRSS1 mRNA"26377693
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PRSS1 protein"23457121
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PRSS1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRSS1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of PRSS1 mRNA15761015
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PRSS1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRSS1 mRNA23178640
C006780bisphenol Abisphenol A results in decreased expression of PRSS1 mRNA26364221
D0200011-Butanol1-Butanol affects the folding of and affects the activity of PRSS1 protein25906839
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PRSS1 mRNA23178640
D003300CopperCopper results in increased activity of PRSS1 protein24052363
D003300CopperCopper deficiency results in increased expression of PRSS1 mRNA26033743
C029892cupric chloridecupric chloride results in decreased expression of PRSS1 mRNA19174923
D004041Dietary FatsDietary Fats results in decreased expression of PRSS1 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of PRSS1 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PRSS1 mRNA28412506
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PRSS1 mRNA21527772
D004052Diethylnitrosamine"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PRSS1 protein"23457121
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of PRSS1 mRNA27638505
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PRSS1 mRNA25187966
D019833GenisteinGenistein results in decreased expression of PRSS1 mRNA23019147
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PRSS1 mRNA27544571
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PRSS1 protein24625837
C523799MRK 003PRSS1 results in decreased susceptibility to MRK 00319903844
D009538NicotineNicotine results in decreased expression of PRSS1 mRNA16949557
C029341oxophenylarsineoxophenylarsine inhibits the reaction [PRSS1 protein results in decreased phosphorylation of and results in increased activity of SRC protein]11035913
D010416PentachlorophenolPentachlorophenol results in decreased expression of PRSS1 mRNA23178640
D011192Potassium DichromatePotassium Dichromate results in increased expression of PRSS1 protein23718831
D012110ReserpineReserpine results in decreased expression of PRSS1 protein8625754
D012110ReserpineReserpine results in increased expression of PRSS1 protein8625754
C459379SCH 351591SCH 351591 results in increased expression of PRSS1 mRNA20585143
D012906SmokeSmoke promotes the reaction [SCT protein results in increased secretion of PRSS1 protein]6156949
C009277sodium arsenatesodium arsenate results in decreased expression of PRSS1 mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of PRSS1 mRNA22561333
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRSS1 mRNA15703262
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PRSS1 protein27319396
D014212TretinoinTretinoin affects the expression of PRSS1 mRNA18230668
D014241TrichloroethylenePRSS1 affects the susceptibility to Trichloroethylene23994554
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PRSS1 mRNA17982090
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of PRSS1 mRNA"22326570
D015032ZincZinc results in increased activity of PRSS1 protein17093223
D015034Zinc OxideZinc Oxide results in increased activity of PRSS1 protein17093223

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-TAS8841182  
GO:0008236serine-type peptidase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0009235cobalamin metabolic process-TAS-  
GO:0022617extracellular matrix disassembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22109105PRSS1 intron mutations in patients with pancreatic cancer and chronic pancreatitis. (2012 Feb)Gao FMol Med Rep
18986377Association analyses of genetic polymorphisms of GSTM1, GSTT1, NQO1, NAT2, LPL, PRSS1, PSTI, and CFTR with chronic alcoholic pancreatitis in Japan. (2010 Feb)Maruyama KAlcohol Clin Exp Res
27846138Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men. (2017 Feb)Polonikov AVPancreas
28454201[Identical Variants Different Disease Course - Genetics of Chronic Pancreatitis]. (2017 May)Beer SDtsch Med Wochenschr
15528021Genetic counseling for hereditary pancreatitis--the role of molecular genetics testing for the cationic trypsinogen gene, cystic fibrosis and serine protease inhibitor Kazal type 1. (2004 Dec)Ellis IGastroenterol Clin North Am
16958673Gene-environment factors that contribute to alcoholic pancreatitis in humans. (2006 Oct)Whitcomb DCJ Gastroenterol Hepatol
11950817Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis. (2002 May)Drenth JPGut
16162302Treatment of familial pancreatic cancer and its precursors. (2005 Oct)Hruban RHCurr Treat Options Gastroenterol
18755888The natural history of hereditary pancreatitis: a national series. (2009 Jan)Rebours VGut
27000817[Hereditary pancreatitis]. (2016 Feb)Dyrla PPol Merkur Lekarski
23751316Clinical and morphological characteristics of sporadic genetically determined pancreatitis as compared to idiopathic pancreatitis: higher risk of pancreatic cancer in CFTR variants. (2013)Hamoir CDigestion
22379635PRSS1-Related Hereditary Pancreatitis (1993)Solomon S-
24624459Pancreatitis Overview (1993)LaRusch J-
16111090Genetics of pancreatitis. (2005)Keim VScand J Surg
22608493[Chronic pancreatitis: beyond alcohol]. (2012 Oct)Vaquero Raya ECGastroenterol Hepatol
16888680[Familial pancreatic cancer]. (2006)Zalatnai AMagy Onkol
18953248Clinical and radiological outcome of patients suffering from chronic pancreatitis associated with gene mutations. (2008 Nov)Frulloni LPancreas
18184119Risk of pancreatic adenocarcinoma in patients with hereditary pancreatitis: a national exhaustive series. (2008 Jan)Rebours VAm J Gastroenterol
18336667Individual susceptibility to alcoholic pancreatitis. (2008 Mar)Apte MVJ Gastroenterol Hepatol
25253127Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (2015 Sep)Derikx MHGut