Gene: PRSS2

5645
TRY2|TRY8|TRYP2
serine protease 2
protein-coding
7q34
Ensembl:ENSG00000275896 MIM:601564 Vega:OTTHUMG00000158904 UniprotKB:P07478
NG_008322.2
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01805MonoisopropylphosphorylserineSmall MoleculeExperimentalTarget
DB01973O-Benzylsulfonyl-SerineSmall MoleculeExperimentalTarget
DB02325Isopropyl AlcoholSmall Molecule67-63-0Approved|InvestigationalTarget
DB02464BenzylamineSmall Molecule100-46-9ExperimentalTarget
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
DB03976PhosphorylisopropaneSmall MoleculeExperimentalTarget
DB04325PhenethylamineSmall Molecule64-04-0ExperimentalTarget
DB044103-PhenylpropylamineSmall Molecule2038-57-5ExperimentalTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of PRSS2 mRNA"26377693
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PRSS2 mRNA"18343893
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PRSS2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of PRSS2 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS2 mRNA"27188386
C496492abrineabrine results in decreased expression of PRSS2 mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PRSS2 gene27153756
D001104ArbutinArbutin results in decreased expression of PRSS2 mRNA17103032
C006632arsenic trioxidearsenic trioxide affects the expression of PRSS2 mRNA28786057
D001280AtrazineAtrazine results in decreased expression of PRSS2 mRNA22378314
D001280Atrazine[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of PRSS2 mRNA16532367
D004958EstradiolEstradiol results in decreased expression of PRSS2 mRNA23019147
D000069286BortezomibBortezomib results in decreased expression of PRSS2 mRNA20977926
C018475butyraldehydebutyraldehyde results in increased expression of PRSS2 mRNA26079696
D002251Carbon TetrachloridePLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of PRSS2 mRNA]16006527
D002922CiguatoxinsCiguatoxins affects the expression of PRSS2 mRNA18353800
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of PRSS2 mRNA20008804
C018021cobaltous chloridecobaltous chloride results in increased expression of PRSS2 mRNA22941251
D003471CuprizoneCuprizone results in decreased expression of PRSS2 mRNA27523638
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PRSS2 mRNA28962523
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of PRSS2 mRNA26924002
C024629dimethyl phthalatedimethyl phthalate results in increased expression of PRSS2 mRNA26924002
D004237Diuron[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of PRSS2 mRNA16532367
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PRSS2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PRSS2 mRNA17942748
D005472FluorouracilFluorouracil affects the expression of PRSS2 mRNA16584549
D004397FonofosFonofos results in increased methylation of PRSS2 promoter22847954
C028904isoproturon[Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of PRSS2 mRNA16532367
C008261lead acetatelead acetate results in increased expression of PRSS2 mRNA20542052
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS2 mRNA"27188386
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of PRSS2 mRNA29162477
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of PRSS2 mRNA26924002
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of PRSS2 mRNA16052530
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRSS2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PRSS2 mRNA"25620056
D009532NickelNickel affects the expression of PRSS2 mRNA14575637
D009532NickelNickel results in increased expression of PRSS2 mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of PRSS2 mRNA]14575637
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PRSS2 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PRSS2 mRNA27935865
C018620oleoresinsoleoresins results in decreased expression of PRSS2 mRNA20008804
D000069463Olive OilOlive Oil analog affects the expression of PRSS2 mRNA17349074
D010278ParathionParathion results in increased methylation of PRSS2 promoter22847954
D010634PhenobarbitalPhenobarbital results in increased expression of PRSS2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRSS2 mRNA26272509
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PRSS2 mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of PRSS2 mRNA17426115|2081375
C006253pirinixic acidpirinixic acid results in increased expression of PRSS2 mRNA12832660
C079198S 1 (combination)PRSS2 protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PRSS2 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of PRSS2 mRNA22561333
C016104sodium bichromatesodium bichromate results in increased expression of PRSS2 mRNA22561333
D013629TamoxifenTamoxifen affects the expression of PRSS2 mRNA17555576
C012568terbufosterbufos results in increased methylation of PRSS2 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRSS2 mRNA18343893|2637764
C009495titanium dioxidetitanium dioxide results in increased expression of PRSS2 mRNA23409001
D014212TretinoinTretinoin results in decreased expression of PRSS2 mRNA23830798
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of PRSS2 mRNA]14575637
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PRSS2 mRNA17982090
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PRSS2 gene25560391
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PRSS2 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IDA12709065  12731883  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005509calcium ion binding-IDA12709065  
GO:0005515protein binding-IPI16192646  
GO:0008236serine-type peptidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IDA12731883  
GO:0019730antimicrobial humoral response-TAS-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030307positive regulation of cell growth-TAS12731883  
GO:0030574collagen catabolic process-IDA12731883  
GO:0030574collagen catabolic process-IMP16192646  
GO:0030574collagen catabolic process-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045785positive regulation of cell adhesion-TAS12731883  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA12731883  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IMP16192646  
GO:0031012extracellular matrix-TAS12731883  
GO:0035578azurophil granule lumen-TAS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1461973DefensinsTAS
R-HSA-1462054Alpha-defensinsTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25253127Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. (2015 Sep)Derikx MHGut
27846138Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men. (2017 Feb)Polonikov AVPancreas