Gene: PRSS3

5646
MTG|PRSS4|T9|TRY3|TRY4
serine protease 3
protein-coding
9p13.3
Ensembl:ENSG00000010438 MIM:613578 Vega:OTTHUMG00000019798 UniprotKB:P35030
NG_029635.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  1.175e-1 (ND)   (Frontal_Cortex)
3.137e-1 (AD)  3.235e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNGR30.913
GDAP1L10.904
FABP30.904
SYP0.904
TAGLN30.903
SULT4A10.901
APBA20.9
GNG30.899
BASP10.898
VSTM2L0.897

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.574
RAI14-0.531
OR4F5-0.518
MBNL3-0.514
YES1-0.507
HEY2-0.489
BAZ1A-0.481
PARD3B-0.481
OR4F29-0.479
LATS2-0.477

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB023084-(1,3,2-Dioxaborolan-2-Yloxy)Butan-1-AminiumSmall MoleculeExperimentalTarget
DB025414-Hydroxybutan-1-AminiumSmall MoleculeExperimentalTarget
DB025854-(Hydroxymethyl)BenzamidineSmall MoleculeExperimentalTarget
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
DB03129[3-(1,3,2-Dioxaborolan-2-Yloxy)Propyl]GuanidineSmall MoleculeExperimentalTarget
DB03637Guanidine-3-PropanolSmall MoleculeExperimentalTarget
DB04109[4-(1,3,2-Dioxaborolan-2-Yloxy)Methyl]BenzamidineSmall MoleculeExperimentalTarget
DB043691,3,2-Dioxaborolan-2-OlSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
D001151ArsenicArsenic results in increased methylation of PRSS3 promoter15987713
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PRSS3 mRNA22300585
C044887beta-methylcholinebeta-methylcholine affects the expression of PRSS3 mRNA21179406
C018475butyraldehydebutyraldehyde results in increased expression of PRSS3 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of PRSS3 mRNA26191083
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRSS3 mRNA20360939
C073316carvacrolcarvacrol results in increased expression of PRSS3 mRNA20008804
D003520CyclophosphamidePRSS3 protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of PRSS3 mRNA27989131
D016572CyclosporineCyclosporine results in decreased methylation of PRSS3 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRSS3 mRNA23914054
D004008DiclofenacDiclofenac results in decreased expression of PRSS3 mRNA26934552
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PRSS3 mRNA21527772
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRSS3 mRNA20360939
D004397FonofosFonofos results in increased methylation of PRSS3 promoter22847954
D005557FormaldehydeFormaldehyde results in increased expression of PRSS3 mRNA27664576
C492448ICG 001ICG 001 results in increased expression of PRSS3 mRNA26191083
C544151jinfukangjinfukang results in increased expression of PRSS3 mRNA27392435
D007854LeadLead results in increased expression of PRSS3 mRNA19921347
C008261lead acetatelead acetate results in increased expression of PRSS3 mRNA20542052
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PRSS3 protein26558463
D009532NickelNickel results in increased expression of PRSS3 mRNA25583101
D010278ParathionParathion results in increased methylation of PRSS3 promoter22847954
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRSS3 mRNA19710929
C079198S 1 (combination)PRSS3 protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PRSS3 mRNA25895662
C016104sodium bichromatesodium bichromate results in decreased expression of PRSS3 mRNA22561333
C012568terbufosterbufos results in increased methylation of PRSS3 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRSS3 mRNA26377647
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PRSS3 mRNA17982090
C088658zoledronic acidzoledronic acid results in increased expression of PRSS3 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IDA6698368  14507909  
GO:0005509calcium ion binding-IDA6698368  
GO:0005515protein binding-IPI6698368  14507909  
GO:0008236serine-type peptidase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IDA6698368  
GO:0006508proteolysis-NAS8294000  
GO:0007586digestion-TAS6698368  14507909  
GO:0009235cobalamin metabolic process-TAS-  
GO:0019730antimicrobial humoral response-TAS-  
GO:0031638zymogen activation-IDA6698368  
GO:0043312neutrophil degranulation-TAS-  
GO:0043542endothelial cell migration-IMP15313892  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA6698368  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04972Pancreatic secretion
hsa04974Protein digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1461973DefensinsTAS
R-HSA-1462054Alpha-defensinsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15987713Carcinogen exposure and gene promoter hypermethylation in bladder cancer. (2006 Jan)Marsit CJCarcinogenesis
17119258Carcinogen exposure and epigenetic silencing in bladder cancer. (2006 Sep)Marsit CJAnn N Y Acad Sci