Gene: MASP1

5648
3MC1|CRARF|CRARF1|MAP1|MASP|MASP3|MAp44|PRSS5|RaRF
mannan binding lectin serine peptidase 1
protein-coding
3q27.3
Ensembl:ENSG00000127241 MIM:600521 Vega:OTTHUMG00000156461 UniprotKB:P48740
NG_029440.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.202e-1 (AD)  9.274e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3105782chr3:187253508 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
F30.818
IL330.802
FAM198A0.797
RFX40.782
CD380.769
FGF20.765
RHPN20.764
TP530.763
FIBIN0.759
PLD20.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CACNA1F-0.458
CCDC177-0.453
CCDC68-0.446
KCNS2-0.445
CALHM1-0.438
FAM160A1-0.437
KCNB2-0.436
OSBPL10-0.435
LHFPL5-0.434
PLXNA4-0.434

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MASP1 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MASP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MASP1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MASP1 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MASP1 mRNA"23146750
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MASP1 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MASP1 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of MASP1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of MASP1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MASP1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MASP1 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of MASP1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MASP1 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MASP1 mRNA19770486|2261060
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of MASP1 mRNA25566086
C006780bisphenol Abisphenol A affects the expression of MASP1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MASP1 mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MASP1 mRNA17484886
D002330CarmustineMASP1 mRNA affects the susceptibility to Carmustine16365179
D000068579CelecoxibCelecoxib results in increased expression of MASP1 mRNA28201806
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of MASP1 mRNA18178546
D002737ChloropreneChloroprene results in decreased expression of MASP1 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MASP1 mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of MASP1 protein28596144
C018021cobaltous chloridecobaltous chloride results in decreased expression of MASP1 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of MASP1 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MASP1 mRNA20106945
C014347decitabinedecitabine results in decreased expression of MASP1 mRNA19194470
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MASP1 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of MASP1 mRNA22733784
D002945CisplatinCisplatin results in decreased expression of MASP1 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of MASP1 mRNA26924002
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MASP1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of MASP1 mRNA19467301|2501614
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of MASP1 mRNA28943392
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of MASP1 mRNA26924002
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of MASP1 mRNA21040762
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MASP1 mRNA12655037|1583489
C082360fipronilfipronil results in increased expression of MASP1 mRNA23962444
D005485FlutamideFlutamide results in decreased expression of MASP1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MASP1 mRNA20938992
D004397FonofosFonofos results in increased methylation of MASP1 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of MASP1 mRNA19167457
C039281furanfuran results in decreased expression of MASP1 mRNA25539665|2619464
D017313FenretinideFenretinide results in decreased expression of MASP1 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of MASP1 mRNA28201806
D007854LeadLead results in increased expression of MASP1 mRNA19921347
C008261lead acetatelead acetate results in decreased expression of MASP1 mRNA22609695
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MASP1 mRNA24056979
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in decreased expression of MASP1 mRNA]24056979
C025340manganese chloridemanganese chloride results in decreased methylation of MASP1 gene27913844
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MASP1 mRNA20938992
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in decreased expression of MASP1 mRNA]24056979
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of MASP1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MASP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MASP1 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of MASP1 mRNA24136188
C028007nickel monoxidenickel monoxide results in decreased expression of MASP1 mRNA19167457
C012655nimesulidenimesulide results in decreased expression of MASP1 mRNA24136188
D010098OxycodoneOxycodone results in decreased expression of MASP1 mRNA23439660
D010278ParathionParathion results in increased methylation of MASP1 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of MASP1 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MASP1 mRNA20936131
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of MASP1 mRNA19429403
D010476PerfumePerfume results in increased expression of MASP1 mRNA24768652
D010634PhenobarbitalPhenobarbital affects the expression of MASP1 mRNA19136022|2309116
D010656PhenylephrinePhenylephrine results in decreased expression of MASP1 mRNA18158353
C006253pirinixic acidpirinixic acid affects the expression of MASP1 mRNA19136022
C006253pirinixic acidpirinixic acid results in decreased expression of MASP1 mRNA17950772|2081375
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of MASP1 mRNA]17950772
D010936Plant ExtractsPlant Extracts results in decreased expression of MASP1 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of MASP1 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of MASP1 mRNA24780913
D012999SomanSoman results in increased expression of MASP1 mRNA19281266
D053260SootSoot results in increased expression of MASP1 mRNA26551751
C047246temozolomideMASP1 mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of MASP1 promoter22847954
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of MASP1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MASP1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MASP1 mRNA19465110|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MASP1 mRNA21215274|2172422
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of MASP1 mRNA28943392
C066340tolcaponetolcapone results in increased expression of MASP1 mRNA24136188
C057693troglitazonetroglitazone results in decreased expression of MASP1 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MASP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MASP1 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of MASP1 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MASP1 gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of MASP1 mRNA26682919
D015032ZincZinc deficiency results in increased expression of MASP1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IDA11527969  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005509calcium ion binding-IDA18596036  
GO:0005515protein binding-IPI10946292  11907111  
GO:0008233peptidase activity-IDA10946292  12538697  
GO:0042803protein homodimerization activity-IPI18596036  
GO:0048306calcium-dependent protein binding-IPI12421953  18596036  
GO ID GO Term Qualifier Evidence PubMed
GO:0001867complement activation, lectin pathway-IBA21873635  
GO:0001867complement activation, lectin pathway-IMP17182967  
GO:0001867complement activation, lectin pathway-TAS-  
GO:0006508proteolysis-IEA-  
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0006956complement activation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA11485744  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-166662Lectin pathway of complement activationTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-166786Creation of C4 and C2 activatorsTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-2855086Ficolins bind to repetitive carbohydrate structures on the target cell surfaceTAS
R-HSA-3000480Scavenging by Class A ReceptorsTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27344311MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. (2016 Sep)von Toerne CDiabetologia