Gene: RELN

5649
ETL7|LIS2|PRO1598|RL
reelin
protein-coding
7q22.1
Ensembl:ENSG00000189056 MIM:600514 Vega:OTTHUMG00000157247 UniprotKB:P78509
NG_011877.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.877e-1 (AD)  2.144e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2283029chr7:103757772 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NDNF0.794
VIP0.79
CHRNA60.79
SP80.766
SLC10A40.765
IGF10.76
SSTR40.757
DLX10.752
PDGFD0.751
CALB20.75

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRE-0.427
AQP1-0.415
HBA2-0.411
TGFB3-0.404
SH2D1B-0.391
CST7-0.385
KCNJ8-0.379
KIF19-0.378
AZGP1-0.377
GNG8-0.376

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]24876378
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of RELN mRNA27638505
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RELN mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of RELN mRNA17562736
D000082Acetaminophen[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of RELN mRNA25607892
D019342Acetic AcidAcetic Acid results in increased expression of RELN mRNA17065238
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RELN mRNA28943387
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of RELN mRNA19770486
C412373AG 1879AG 1879 inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]24876378
C412373AG 1879AG 1879 inhibits the reaction [RELN protein results in increased phosphorylation of ARC mRNA]24876378
C412373AG 1879AG 1879 inhibits the reaction [RELN protein results in increased phosphorylation of MAPK1 protein]24876378
C412373AG 1879AG 1879 inhibits the reaction [RELN protein results in increased phosphorylation of MAPK3 protein]24876378
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RELN mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of RELN mRNA"22863853
D000726Androgen Antagonists[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of RELN mRNA25607892
C015001arsenitearsenite results in decreased methylation of RELN promoter23974009
D001280AtrazineAtrazine results in decreased expression of RELN mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of RELN mRNA22323515
C487081belinostatbelinostat results in increased expression of RELN mRNA26272509
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of RELN mRNA21635667
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RELN mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RELN mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of RELN mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RELN mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RELN mRNA"26238291
D001629BezafibrateBezafibrate results in increased expression of RELN mRNA18787029
C006780bisphenol Abisphenol A results in decreased expression of RELN mRNA25594700
C006780bisphenol Abisphenol A affects the expression of RELN mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of RELN mRNA25607892
C006780bisphenol Abisphenol A results in decreased expression of RELN mRNA25963729
C006780bisphenol Abisphenol A results in increased methylation of RELN gene28505145
C006780bisphenol ACurcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA]25963729
C013418bromfenacoumbromfenacoum results in increased expression of RELN protein28903499
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of RELN mRNA25607892
D002220CarbamazepineCarbamazepine results in decreased expression of RELN25524013
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of RELN mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in decreased expression of RELN mRNA16675515
D003024ClozapineClozapine results in decreased expression of RELN mRNA17266109
D003024ClozapineClozapine results in decreased methylation of RELN promoter18757738
D003024ClozapineValproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]18757738
D003024ClozapineClozapine results in decreased expression of RELN protein19359144
C018021cobaltous chloridecobaltous chloride results in decreased expression of RELN mRNA22941251
D003042CocaineCocaine results in increased expression of RELN mRNA27899881
D019327Copper SulfateCopper Sulfate results in decreased expression of RELN mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [bisphenol A results in decreased expression of RELN mRNA]25963729
D003474CurcuminCurcumin results in increased expression of RELN mRNA25963729
D016572CyclosporineCyclosporine results in decreased expression of RELN mRNA25562108|2798913
D016572CyclosporineCyclosporine results in decreased expression of RELN mRNA19770486
D003561CytarabineCytarabine results in decreased expression of RELN mRNA21198554
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
D002945CisplatinCisplatin results in decreased expression of RELN mRNA22023808
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
D004008DiclofenacDiclofenac results in decreased expression of RELN mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of RELN mRNA18042831
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of RELN mRNA19371625
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of RELN mRNA17547211
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in increased expression of RELN mRNA17065238
D004317DoxorubicinDoxorubicin inhibits the reaction [DNMT1 binds to RELN promoter]17065238
D004317Doxorubicin[Doxorubicin inhibits the reaction [DNMT1 binds to RELN promoter]] which results in increased expression of RELN mRNA17065238|1706523
D004317DoxorubicinDoxorubicin results in increased expression of RELN mRNA17065238
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of RELN mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RELN mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RELN mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of RELN gene16495775
D005473FluoxetineFluoxetine results in increased expression of RELN mRNA19359144
D005485FlutamideFlutamide results in decreased expression of RELN mRNA24136188
D005978GlutathioneGlutathione deficiency results in decreased expression of RELN mRNA20621112
D006220HaloperidolHaloperidol results in decreased expression of RELN mRNA19359144
D006220HaloperidolHaloperidol results in decreased expression of RELN protein19359144
D017313FenretinideFenretinide results in increased expression of RELN mRNA28973697
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of RELN mRNA"21635667
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of RELN mRNA25119042
C008261lead acetatelead acetate affects the expression of RELN mRNA21147602
C008261lead acetatelead acetate results in increased expression of RELN protein21147602
C008261lead acetatelead acetate results in increased expression of RELN mRNA24260418
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
D008094LithiumLithium results in decreased expression of RELN mRNA19359144
D008094LithiumLithium results in decreased expression of RELN protein19359144
C025340manganese chloridemanganese chloride results in increased expression of RELN mRNA22407947
C042720mercuric bromidemercuric bromide results in increased expression of RELN mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
D008628MercuryMercury results in decreased expression of RELN mRNA17547211
D008713MethimazoleMethimazole results in increased expression of RELN protein20347957
D008715MethionineMethionine promotes the reaction [MECP2 binds to RELN promoter]16113080
D008715MethionineMethionine results in decreased expression of RELN20442623
D008715MethionineMethionine results in decreased expression of RELN mRNA15671176|1573766
D008715MethionineMethionine results in decreased expression of RELN protein16113080
D008715MethionineMethionine results in increased methylation of RELN promoter15671176|1573766
D008715MethionineValproic Acid inhibits the reaction [Methionine results in decreased expression of RELN protein]20442623
D008715MethionineValproic Acid inhibits the reaction [Methionine results in increased methylation of RELN promoter]15737665
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of RELN mRNA15120970
D009020MorphineMorphine results in decreased expression of RELN mRNA21178816
D009151Mustard GasMustard Gas results in decreased expression of RELN mRNA15674843
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of RELN mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RELN mRNA19812364
C051752nefazodonenefazodone results in decreased expression of RELN mRNA24136188
D009532NickelNickel results in decreased expression of RELN mRNA25583101
C012655nimesulidenimesulide results in decreased expression of RELN mRNA24136188
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of RELN mRNA25607892
C076029olanzapineolanzapine results in increased expression of RELN mRNA19359144
C076029olanzapineolanzapine results in increased expression of RELN protein19359144
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"RELN gene affects the susceptibility to O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"16783542
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of RELN mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of RELN mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of RELN mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of RELN mRNA26272509
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of RELN mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of RELN mRNA25119042
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of RELN mRNA17097637
D010622PhencyclidinePhencyclidine results in decreased expression of RELN mRNA17266109
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of RELN mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of RELN mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of RELN mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RELN mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of RELN mRNA23557933
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
D011372ProgestinsProgestins results in decreased expression of RELN mRNA19609016
C045950propiconazolepropiconazole results in decreased expression of RELN mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of RELN mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of RELN protein20347957
C502851quinocetonequinocetone results in increased expression of RELN mRNA27046791
C059514resveratrolresveratrol results in increased expression of RELN mRNA19371625
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of RELN mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of RELN gene28589171
D013469SulpirideSulpiride results in decreased methylation of RELN promoter18757738|1911032
D013469SulpirideValproic Acid promotes the reaction [Sulpiride results in decreased methylation of RELN promoter]18757738|1911032
D013605T-2 ToxinT-2 Toxin results in increased expression of RELN mRNA26314264
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RELN mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RELN mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RELN mRNA15328365|1977048
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of RELN mRNA25729387
D019772TopotecanTopotecan results in decreased expression of RELN mRNA25729387
D014212TretinoinTretinoin results in increased expression of RELN mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of RELN mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride affects the expression of RELN mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of RELN mRNA21346803
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of RELN mRNA29024780
D014403TubocurarineTubocurarine results in increased expression of RELN mRNA19728367
C113580U 0126U 0126 inhibits the reaction [RELN protein results in increased phosphorylation of ARC mRNA]24876378
C113580U 0126U 0126 inhibits the reaction [RELN protein results in increased phosphorylation of MAPK1 protein]24876378
C113580U 0126U 0126 inhibits the reaction [RELN protein results in increased phosphorylation of MAPK3 protein]24876378
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of RELN mRNA24849673|2597931
D014635Valproic AcidValproic Acid results in decreased expression of RELN25524013
D014635Valproic AcidValproic Acid results in increased expression of RELN mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of RELN gene29154799
D014635Valproic AcidValproic Acid inhibits the reaction [MECP2 binds to RELN promoter]16113080
D014635Valproic AcidValproic Acid inhibits the reaction [Methionine results in decreased expression of RELN protein]20442623
D014635Valproic AcidValproic Acid inhibits the reaction [Methionine results in increased methylation of RELN promoter]15737665
D014635Valproic AcidValproic Acid promotes the reaction [Clozapine results in decreased methylation of RELN promoter]18757738
D014635Valproic AcidValproic Acid promotes the reaction [Sulpiride results in decreased methylation of RELN promoter]18757738|1911032
D014635Valproic AcidValproic Acid results in decreased methylation of RELN promoter20716949
D014635Valproic AcidValproic Acid results in increased expression of RELN20716949
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RELN gene25560391
D020888VigabatrinVigabatrin results in increased expression of RELN protein21490592
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of RELN mRNA25607892
C025643vinclozolinvinclozolin affects the expression of RELN mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of RELN mRNA"27188386
C111237vorinostatvorinostat results in increased expression of RELN mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008236serine-type peptidase activity-IEA-  
GO:0046872metal ion binding-IEA-  
GO:0070325lipoprotein particle receptor binding-ISS10571240  
GO:0070326very-low-density lipoprotein particle receptor binding-ISS10571240  
GO ID GO Term Qualifier Evidence PubMed
GO:0000904cell morphogenesis involved in differentiation-ISS-  
GO:0001764neuron migration-ISS-  
GO:0006508proteolysis-IEA-  
GO:0007155cell adhesion-IEA-  
GO:0007411axon guidance-ISS-  
GO:0007411axon guidance-TAS-  
GO:0007417central nervous system development-ISS-  
GO:0007420brain development-ISS-  
GO:0007616long-term memory-IEA-  
GO:0008306associative learning-IEA-  
GO:0010001glial cell differentiation-ISS-  
GO:0010976positive regulation of neuron projection development-ISS-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0016358dendrite development-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-ISS-  
GO:0021511spinal cord patterning-ISS-  
GO:0021517ventral spinal cord development-IEA-  
GO:0021766hippocampus development-ISS-  
GO:0021800cerebral cortex tangential migration-ISS-  
GO:0021819layer formation in cerebral cortex-IEA-  
GO:0032008positive regulation of TOR signaling-IEA-  
GO:0032793positive regulation of CREB transcription factor activity-ISS-  
GO:0035418protein localization to synapse-IEA-  
GO:0038026reelin-mediated signaling pathway-ISS10571240  
GO:0045860positive regulation of protein kinase activity-ISS-  
GO:0048265response to pain-ISS-  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-ISS10571240  
GO:0050795regulation of behavior-ISS-  
GO:0050804modulation of chemical synaptic transmission-ISS-  
GO:0051057positive regulation of small GTPase mediated signal transduction-ISS-  
GO:0051968positive regulation of synaptic transmission, glutamatergic-ISS-  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0061003positive regulation of dendritic spine morphogenesis-ISS-  
GO:0061098positive regulation of protein tyrosine kinase activity-ISS-  
GO:0090129positive regulation of synapse maturation-ISS-  
GO:0097114NMDA glutamate receptor clustering-IEA-  
GO:0097119postsynaptic density protein 95 clustering-IEA-  
GO:0097120receptor localization to synapse-IEA-  
GO:0097477lateral motor column neuron migration-IEA-  
GO:1900273positive regulation of long-term synaptic potentiation-ISS-  
GO:1902078positive regulation of lateral motor column neuron migration-IEA-  
GO:2000310regulation of NMDA receptor activity-ISS-  
GO:2000463positive regulation of excitatory postsynaptic potential-ISS-  
GO:2000969positive regulation of AMPA receptor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IEA-  
GO:0030425dendrite-ISS-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8866376Reelin signalling pathwayTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal