Gene: KLK7

5650
PRSS6|SCCE|hK7
kallikrein related peptidase 7
protein-coding
19q13.41
Ensembl:ENSG00000169035 MIM:604438 Vega:OTTHUMG00000182917 UniprotKB:P49862
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.095e-1 (AD)  8.650e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMYD20.832
KCNC20.832
MPPED10.825
TMEM1550.814
FHOD30.809
ADCY10.809
TMEM151B0.805
EHD30.804
NEUROD60.803
RIMKLA0.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
REST-0.55
WWTR1-0.528
AGTRAP-0.521
TGIF1-0.518
BAZ1A-0.517
YES1-0.515
HEY2-0.511
CNN2-0.51
CHST14-0.51
RBPMS-0.506

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08038L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of KLK7 mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of KLK7 mRNA28959563
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of KLK7 mRNA17254854
C000228aristolochic acid Iaristolochic acid I results in decreased expression of KLK7 mRNA17483316
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to KLK7 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of KLK7 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of KLK7 mRNA26191083
D002104CadmiumCadmium results in increased expression of KLK7 mRNA21120746
D002220CarbamazepineCarbamazepine affects the expression of KLK7 mRNA25979313
D002945CisplatinKLK7 protein affects the susceptibility to Cisplatin16217747
D002117CalcitriolCalcitriol results in increased expression of KLK7 mRNA26485663
C056516exemestaneexemestane results in increased expression of KLK7 mRNA17254854
C039281furanfuran results in increased methylation of KLK7 gene22079235
C492448ICG 001ICG 001 results in increased expression of KLK7 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of KLK7 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KLK7 mRNA26752646
C046012pentanalpentanal results in increased expression of KLK7 mRNA26079696
D011192Potassium DichromatePotassium Dichromate results in increased expression of KLK7 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of KLK7 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of KLK7 mRNA24780913
D012906SmokeSmoke results in decreased expression of KLK7 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of KLK7 mRNA12634122
D012969Sodium FluorideSodium Fluoride results in decreased expression of KLK7 mRNA27862939
C501413tesaglitazartesaglitazar results in increased expression of KLK7 mRNA21515302
D013853ThioacetamideThioacetamide results in decreased expression of KLK7 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of KLK7 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KLK7 mRNA27480279
D014212TretinoinTretinoin results in increased expression of KLK7 mRNA16249480
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of KLK7 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0008233peptidase activity-IMP17012259  
GO:0008236serine-type peptidase activity-TAS8034709  
GO ID GO Term Qualifier Evidence PubMed
GO:0002803positive regulation of antibacterial peptide production-IBA21873635  
GO:0002803positive regulation of antibacterial peptide production-IMP17012259  
GO:0006508proteolysis-IEA-  
GO:0008544epidermis development-TAS8034709  
GO:0022617extracellular matrix disassembly-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IMP17012259  
GO:0030141secretory granule-IBA21873635  
GO:0097209epidermal lamellar body-IDA15675955  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res