Gene: PRSS8

5652
CAP1|PROSTASIN
serine protease 8
protein-coding
16p11.2
Ensembl:ENSG00000052344 MIM:600823 Vega:OTTHUMG00000176750 UniprotKB:Q16651
NC_000016.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.633e-1 (AD)  2.615e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR90.563
CELSR10.543
EPPIN0.528
NPC1L10.514
C9orf1520.511
RCC10.508
FSCN30.507
TDRG10.506
JMJD60.503
DERL30.502

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C5-0.359
CDNF-0.338
FAM227B-0.336
AGL-0.334
UNC5CL-0.332
PLK4-0.329
MYH15-0.327
CCT6B-0.321
CARF-0.317
ZNF43-0.317

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB069001-[4-(hydroxymethyl)phenyl]guanidineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PRSS8 mRNA"18281256
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PRSS8 mRNA"22698814|2741311
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS8 mRNA"25510870
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of PRSS8 mRNA"21724226
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of PRSS8 mRNA"21724226
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS8 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of PRSS8 mRNA"20959002
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS8 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PRSS8 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS8 mRNA"25510870
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PRSS8 mRNA25088246
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C496492abrineabrine results in increased expression of PRSS8 mRNA22595364
D020106AcrylamideAcrylamide results in decreased expression of PRSS8 mRNA28959563
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of PRSS8 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PRSS8 mRNA27153756
C040534alpha-hexachlorocyclohexanealpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA17785943
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PRSS8 mRNA16483693
D001151ArsenicArsenic affects the methylation of PRSS8 gene25304211
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PRSS8 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PRSS8 mRNA18164116
D004958EstradiolEstradiol results in decreased expression of PRSS8 mRNA23019147
C006780bisphenol Abisphenol A affects the expression of PRSS8 mRNA25181051
D002104CadmiumCadmium results in increased expression of PRSS8 mRNA24376830
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PRSS8 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS8 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of PRSS8 mRNA19549813
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of PRSS8 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of PRSS8 mRNA19167446
D016572CyclosporineCyclosporine affects the expression of PRSS8 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PRSS8 mRNA23914054
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PRSS8 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of PRSS8 mRNA19680557
D019422Dietary SucroseDietary Sucrose results in increased expression of PRSS8 mRNA26033743
C014476diethyl maleatediethyl maleate results in decreased expression of PRSS8 mRNA21161181
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PRSS8 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PRSS8 mRNA18164116
C024629dimethyl phthalatedimethyl phthalate affects the expression of PRSS8 mRNA26924002
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of PRSS8 mRNA24690739
D004237DiuronDiuron results in decreased expression of PRSS8 mRNA21551480
C118739entinostatentinostat results in increased expression of PRSS8 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of PRSS8 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of PRSS8 mRNA21233418
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of PRSS8 mRNA17347304
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of PRSS8 mRNA17347304
D005419FlavonoidsFlavonoids results in increased expression of PRSS8 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS8 mRNA20938992
D019833GenisteinESR2 promotes the reaction [Genistein results in decreased expression of PRSS8 protein]20884965
D019833GenisteinGenistein results in decreased expression of PRSS8 protein20884965
D017313FenretinideFenretinide results in increased expression of PRSS8 mRNA28973697
D048628KetolidesKetolides analog results in increased expression of PRSS8 mRNA24967691
C533894LG 100815LG 100815 results in increased expression of PRSS8 mRNA16951191
C042720mercuric bromidemercuric bromide results in increased expression of PRSS8 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PRSS8 mRNA20938992
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PRSS8 mRNA24810058
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PRSS8 mRNA26924002
C500085muraglitazarmuraglitazar results in decreased expression of PRSS8 mRNA21515302
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PRSS8 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PRSS8 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PRSS8 mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of PRSS8 mRNA24768652
C029938nickel sulfatenickel sulfate results in increased expression of PRSS8 mRNA18651567
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of PRSS8 mRNA"16951191
D000073878Palm OilPalm Oil affects the expression of PRSS8 mRNA19680557
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PRSS8 mRNA26272509
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRSS8 mRNA"25510870
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PRSS8 mRNA28511854
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PRSS8 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of PRSS8 mRNA19136022|2309116
D010634PhenobarbitalPhenobarbital results in increased expression of PRSS8 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRSS8 mRNA26272509
C006253pirinixic acidpirinixic acid affects the expression of PRSS8 mRNA19136022|2381119
C045950propiconazolepropiconazole results in increased expression of PRSS8 mRNA21278054
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of PRSS8 mRNA19167446
D015474IsotretinoinIsotretinoin results in decreased expression of PRSS8 mRNA20436886
C089730rosiglitazonerosiglitazone results in decreased expression of PRSS8 mRNA21515302
D012643SeleniumSelenium results in increased expression of PRSS8 mRNA19244175
D012906SmokeSmoke results in decreased expression of PRSS8 mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of PRSS8 mRNA12634122
D053260SootSoot results in decreased expression of PRSS8 mRNA26551751
C013698tallowtallow affects the expression of PRSS8 mRNA19680557
D013629TamoxifenTamoxifen results in decreased expression of PRSS8 mRNA25123088
C501413tesaglitazartesaglitazar results in decreased expression of PRSS8 mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of PRSS8 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRSS8 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRSS8 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRSS8 mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PRSS8 mRNA20959002
D013853ThioacetamideThioacetamide results in increased expression of PRSS8 mRNA23411599
D014212TretinoinTretinoin results in increased expression of PRSS8 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PRSS8 mRNA24935251|2627250
D014520UrethaneUrethane results in decreased expression of PRSS8 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRSS8 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PRSS8 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PRSS8 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PRSS8 mRNA17292431
C029297vinylidene chloridevinylidene chloride results in decreased expression of PRSS8 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-IEA-  
GO:0005515protein binding-IPI19911255  
GO:0008236serine-type peptidase activity-IBA21873635  
GO:0008236serine-type peptidase activity-TAS8034638  
GO:0017080sodium channel regulator activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0010765positive regulation of sodium ion transport-IBA21873635  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS10077646  
GO:0005615extracellular space-HDA16502470  
GO:0005886plasma membrane-IDA19911255  
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0019897extrinsic component of plasma membrane-IBA21873635  
GO:0046658anchored component of plasma membrane-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23724145Long-term exposure to cigarette smoke extract induces hypomethylation at the RUNX3 and IGF2-H19 loci in immortalized human urothelial cells. (2013)Chen LMPLoS One