Gene: KLK6

5653
Bssp|Klk7|PRSS18|PRSS9|SP59|hK6
kallikrein related peptidase 6
protein-coding
19q13.41
Ensembl:ENSG00000167755 MIM:602652 Vega:OTTHUMG00000183098 UniprotKB:Q92876
NG_011825.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.977e-1 (AD)  8.638e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJB10.965
FA2H0.952
MAG0.944
CAPN30.937
MYRF0.932
SLC45A30.932
TF0.93
ENPP20.924
GPR620.921
MOG0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.351
NR2F2-0.342
LTK-0.341
PAX2-0.341
CERKL-0.327
NEUROD1-0.327
THSD7A-0.327
GPR153-0.326
NHS-0.32
WTIP-0.316

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
ID Drug Name Action PubMed
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KLK6 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KLK6 mRNA23626723
D020106AcrylamideAcrylamide results in decreased expression of KLK6 mRNA28959563
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KLK6 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KLK6 mRNA21839799
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLK6 mRNA19619570
D004958EstradiolEstradiol results in increased expression of KLK6 mRNA19619570|2118537
C006780bisphenol Abisphenol A results in decreased expression of KLK6 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of KLK6 mRNA26191083
D002211CapsaicinCapsaicin results in increased expression of KLK6 mRNA20349343
C026690cerous chloridecerous chloride results in decreased expression of KLK6 mRNA23573234
D002922CiguatoxinsCiguatoxins affects the expression of KLK6 mRNA18353800
D019327Copper SulfateCopper Sulfate results in increased expression of KLK6 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of KLK6 mRNA26577399|2752363
D003561CytarabineCytarabine results in decreased expression of KLK6 mRNA21198554
C014347decitabinedecitabine affects the expression of KLK6 mRNA23300844
D013759DronabinolDronabinol results in decreased expression of KLK6 mRNA17578508
D002945CisplatinCisplatin affects the expression of KLK6 mRNA23300844
D002945CisplatinKLK6 protein affects the susceptibility to Cisplatin16217747
D004077DigoxinABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]25419811
D002117CalcitriolCalcitriol results in increased expression of KLK6 mRNA12040012|1600243
D002117CalcitriolKetoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA]26485663
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of KLK6 mRNA21592394
C084101doramectinABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA]25419811
C118739entinostatentinostat results in increased expression of KLK6 mRNA27188386
D005419FlavonoidsFlavonoids results in increased expression of KLK6 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of KLK6 protein15352031
D005472FluorouracilKLK6 protein affects the susceptibility to Fluorouracil15352031
C492448ICG 001ICG 001 results in increased expression of KLK6 mRNA26191083
D007559IvermectinABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]25419811
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KLK6 mRNA26752646
D007654KetoconazoleKetoconazole promotes the reaction [Calcitriol results in increased expression of KLK6 mRNA]26485663
C008261lead acetatelead acetate results in increased expression of KLK6 mRNA22641619
D008095Lithocholic Acid[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA21311750
D008727MethotrexateKLK6 protein affects the susceptibility to Methotrexate16217747
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KLK6 mRNA"20188158
C027837milbemycinABCB1 gene mutant form affects the reaction [milbemycin affects the expression of KLK6 mRNA]25419811
D009151Mustard GasMustard Gas results in increased expression of KLK6 mRNA15674844
D009532NickelNickel results in increased expression of KLK6 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of KLK6 mRNA19167457
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of KLK6 mRNA17616710
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of KLK6 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KLK6 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of KLK6 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of KLK6 mRNA23557933
D011374Progesterone[Progesterone results in increased activity of PGR protein] which results in increased expression of KLK6 mRNA15845616
D011441PropylthiouracilPropylthiouracil results in decreased expression of KLK6 mRNA24780913
C078903seocalcitolseocalcitol results in increased expression of KLK6 mRNA12040012
D012822Silicon DioxideSilicon Dioxide results in increased expression of KLK6 mRNA22431001
D012906SmokeSmoke results in decreased expression of KLK6 mRNA21095227
C017947sodium arsenitesodium arsenite affects the methylation of KLK6 gene28589171
D012999SomanSoman results in increased expression of KLK6 mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of KLK6 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of KLK6 mRNA21592394
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLK6 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KLK6 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK6 mRNA19619570|2315218
D014050TolueneToluene results in decreased expression of KLK6 mRNA22166486
D014050TolueneToluene results in increased expression of KLK6 mRNA22166486
D014212TretinoinTretinoin results in increased expression of KLK6 mRNA21934132
D014635Valproic AcidValproic Acid results in increased expression of KLK6 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions affects the expression of KLK6 mRNA23940539
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KLK6 mRNA27935865
C088658zoledronic acidzoledronic acid results in decreased expression of KLK6 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA16885167  
GO:0004252serine-type endopeptidase activity-NAS12878203  
GO:0005515protein binding-IPI12709365  12878203  
GO ID GO Term Qualifier Evidence PubMed
GO:0007417central nervous system development-NAS12589961  
GO:0009611response to wounding-NAS12016211  
GO:0010975regulation of neuron projection development-IEA-  
GO:0016540protein autoprocessing-NAS12878203  
GO:0030574collagen catabolic process-NAS12878203  
GO:0042246tissue regeneration-NAS12878203  
GO:0042445hormone metabolic process-NAS11668196  
GO:0042552myelination-NAS11668196  
GO:0042982amyloid precursor protein metabolic process-NAS12709365  
GO:0045595regulation of cell differentiation-NAS11668196  
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway-IDA16885167  
GO:0070997neuron death-IMP22166940  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA11668196  
GO:0005615extracellular space-HDA16502470  
GO:0005730nucleolus-IEA-  
GO:0005737cytoplasm-IDA11668196  
GO:0005739mitochondrion-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0030141secretory granule-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res