Gene info: ID 5654

Gene: HTRA1

GENE ID: 5654

Description: HtrA serine peptidase 1

Gene type: protein-coding

Location: 10q26.13

dbXrefs: Ensembl:ENSG00000166033 MIM:602194 Vega:OTTHUMG00000019186 UniprotKB:Q92743

RefSeq: NG_011554.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 45

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.393e-1 (AD) 6.496e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GLUD1	0.902
CSRP1	0.901
PON2	0.898
PRDX6	0.895
PTGDS	0.894
NDRG2	0.886
HADHB	0.885
ALDH2	0.885
TTYH1	0.88
APOE	0.878

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.675
OR4F29	-0.65
TRIM58	-0.319
KCNH5	-0.315
PROKR2	-0.314
KLHL38	-0.306
GDF7	-0.305
KCNH7	-0.302
KCNH1	-0.3
COL19A1	-0.295

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of HTRA1 mRNA"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HTRA1 mRNA]"	19414516
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of HTRA1 mRNA]"	19414516
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of HTRA1 mRNA"	21346803
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of HTRA1 mRNA"	20206263
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of HTRA1 mRNA	21420995
D000082	Acetaminophen	Acetaminophen results in decreased expression of HTRA1 mRNA	17585979
D000086	Acetazolamide	Acetazolamide results in increased expression of HTRA1 mRNA	19274763
D000242	Cyclic AMP	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of HTRA1 mRNA]"	19414516
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of HTRA1 mRNA	28522335
D000638	Amiodarone	Amiodarone affects the expression of HTRA1 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HTRA1 mRNA	16483693
D000968	Antimycin A	Antimycin A results in increased expression of HTRA1 mRNA	19304788
C547126	AZM551248	AZM551248 results in increased expression of HTRA1 mRNA	22323515
D001553	Benzbromarone	Benzbromarone affects the expression of HTRA1 mRNA	19483382
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HTRA1 mRNA	20713471
C006780	bisphenol A	bisphenol A results in increased expression of HTRA1 mRNA	28159858
C006780	bisphenol A	bisphenol A results in increased expression of HTRA1 mRNA	25181051\|2909715
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of HTRA1 mRNA]	19228888
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of HTRA1 mRNA	15336504
C584509	C646 compound	C646 compound results in increased expression of HTRA1 mRNA	26191083
D002104	Cadmium	Cadmium results in decreased expression of HTRA1 mRNA	23369406
D002122	Calcium Chloride	Calcium Chloride results in decreased expression of HTRA1 protein	25824407
C010063	carbonyl sulfide	carbonyl sulfide results in increased expression of HTRA1 mRNA	19395590
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) affects the expression of HTRA1 mRNA	17851650
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of HTRA1 mRNA	26272509
C100187	chloropicrin	chloropicrin affects the expression of HTRA1 mRNA	26352163
C100187	chloropicrin	chloropicrin results in decreased expression of HTRA1 mRNA	28476498
D002922	Ciguatoxins	Ciguatoxins affects the expression of HTRA1 mRNA	18353800
D002994	Clofibrate	Clofibrate affects the expression of HTRA1 mRNA	19483382
D002995	Clofibric Acid	Clofibric Acid affects the expression of HTRA1 mRNA	17602206
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HTRA1 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HTRA1 mRNA	24386269
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of HTRA1 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of HTRA1 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of HTRA1 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of HTRA1 mRNA	27989131
D003561	Cytarabine	Cytarabine results in decreased expression of HTRA1 mRNA	21198554
D000069439	Dasatinib	Dasatinib results in increased expression of HTRA1 mRNA	20579391
D003840	Deoxycholic Acid	HTRA1 protein affects the susceptibility to Deoxycholic Acid	12507930
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of HTRA1 mRNA	24893172
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of HTRA1 mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of HTRA1 mRNA	23041725
D004041	Dietary Fats	Dietary Fats results in decreased expression of HTRA1 mRNA	25016146
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of HTRA1 mRNA	19041683
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of HTRA1 mRNA	17005392
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of HTRA1 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HTRA1 mRNA"	22485181
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of HTRA1 mRNA	26924002
D004237	Diuron	Diuron results in decreased expression of HTRA1 mRNA	25152437
D004317	Doxorubicin	HTRA1 mRNA affects the susceptibility to Doxorubicin	16243817
D000431	Ethanol	Ethanol results in increased expression of HTRA1 mRNA	28069986
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTRA1 mRNA	17942748
D005001	Ethionine	Ethionine affects the expression of HTRA1 mRNA	19483382
D005472	Fluorouracil	Fluorouracil results in increased expression of HTRA1 protein	15352031
D005472	Fluorouracil	HTRA1 protein affects the susceptibility to Fluorouracil	15352031
D005485	Flutamide	Flutamide results in decreased expression of HTRA1 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of HTRA1 mRNA	24793618
D004397	Fonofos	Fonofos results in increased methylation of HTRA1 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of HTRA1 mRNA	28937961
C039281	furan	furan results in decreased expression of HTRA1 mRNA	25539665
D017313	Fenretinide	Fenretinide results in decreased expression of HTRA1 mRNA	28973697
C492448	ICG 001	ICG 001 results in increased expression of HTRA1 mRNA	26191083
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HTRA1 mRNA	25613284
C544151	jinfukang	jinfukang results in increased expression of HTRA1 mRNA	27392435
C561695	(+)-JQ1 compound	[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of HTRA1 protein	27169980
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HTRA1 mRNA	27432991
D007649	Ketamine	Ketamine results in increased expression of HTRA1 mRNA	20080153
D007657	Ketone Bodies	Ketone Bodies results in increased expression of HTRA1 mRNA	16807920
C533894	LG 100815	LG 100815 results in increased expression of HTRA1 mRNA	16951191
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of HTRA1 mRNA"	24972896
C042720	mercuric bromide	mercuric bromide results in decreased expression of HTRA1 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
D008727	Methotrexate	Methotrexate affects the expression of HTRA1 mRNA	18502557
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of HTRA1 mRNA	16507463
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of HTRA1 mRNA	26924002
C523799	MRK 003	HTRA1 results in increased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in decreased expression of HTRA1 mRNA	25102026
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of HTRA1 mRNA"	25554681
C051752	nefazodone	nefazodone results in decreased expression of HTRA1 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of HTRA1 mRNA	24768652
C012655	nimesulide	nimesulide results in decreased expression of HTRA1 mRNA	24136188
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of HTRA1 mRNA	20971185
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in increased expression of HTRA1 mRNA"	16951191
D009853	Omeprazole	Omeprazole affects the expression of HTRA1 mRNA	19483382
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of HTRA1 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of HTRA1 mRNA	25729387
D010278	Parathion	Parathion results in increased methylation of HTRA1 promoter	22847954
D010634	Phenobarbital	Phenobarbital affects the expression of HTRA1 mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTRA1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of HTRA1 mRNA	26272509
C006253	pirinixic acid	pirinixic acid affects the expression of HTRA1 mRNA	19483382
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of HTRA1 mRNA	22714537
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of HTRA1 mRNA	23608068
C045950	propiconazole	propiconazole results in decreased expression of HTRA1 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil affects the expression of HTRA1 mRNA	19483382
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HTRA1 mRNA	24780913
D054328	Proton Pump Inhibitors	Proton Pump Inhibitors results in decreased expression of HTRA1 mRNA	25626140
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of HTRA1 mRNA	27029645
D015474	Isotretinoin	Isotretinoin results in increased expression of HTRA1 mRNA	20436886
D012402	Rotenone	Rotenone results in increased expression of HTRA1 mRNA	19304788
C078903	seocalcitol	seocalcitol results in increased expression of HTRA1 mRNA	12040012
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of HTRA1 mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in decreased expression of HTRA1 mRNA	16507463
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of HTRA1 mRNA]	19228888
D014284	Triiodothyronine	Triiodothyronine results in increased expression of HTRA1 mRNA	19228888
D013629	Tamoxifen	Tamoxifen results in increased expression of HTRA1 mRNA	25123088
C012568	terbufos	terbufos results in increased methylation of HTRA1 promoter	22847954
D013739	Testosterone	Testosterone results in increased expression of HTRA1 mRNA	15788153
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HTRA1 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HTRA1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HTRA1 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HTRA1 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HTRA1 mRNA	25613284
D013853	Thioacetamide	Thioacetamide affects the expression of HTRA1 mRNA	19483382
D013974	Thyroxine	Thyroxine results in increased expression of HTRA1 mRNA	23935926
C009495	titanium dioxide	titanium dioxide results in decreased expression of HTRA1 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of HTRA1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of HTRA1 mRNA	25729387
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of HTRA1 mRNA	17905399
C012589	trichostatin A	trichostatin A results in decreased expression of HTRA1 mRNA	24935251
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HTRA1 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of HTRA1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of HTRA1 mRNA	23179753
D014635	Valproic Acid	Valproic Acid results in increased expression of HTRA1 mRNA	27188386\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of HTRA1 mRNA	19136453
D014638	Vanadates	Vanadates results in increased expression of HTRA1 mRNA	22714537
C551177	vemurafenib	[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of HTRA1 protein	27169980
D014810	Vitamin E	Vitamin E results in increased expression of HTRA1 mRNA	19244175
C088658	zoledronic acid	zoledronic acid results in decreased expression of HTRA1 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004252	serine-type endopeptidase activity	-	EXP	9852107
GO:0005515	protein binding	-	IPI	26436840
GO:0005520	insulin-like growth factor binding	-	IEA	-
GO:0008236	serine-type peptidase activity	-	ISS	-
GO:0042802	identical protein binding	-	IPI	21297635 22578544

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001558	regulation of cell growth	-	IEA	-
GO:0001890	placenta development	-	IEA	-
GO:0006508	proteolysis	-	ISS	-
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	-	IEA	-
GO:0030514	negative regulation of BMP signaling pathway	-	IEA	-
GO:0050679	positive regulation of epithelial cell proliferation	-	IEA	-
GO:0050687	negative regulation of defense response to virus	-	IEA	-
GO:0060718	chorionic trophoblast cell differentiation	-	IEA	-
GO:0097187	dentinogenesis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	TAS	9852107
GO:0005829	cytosol	-	IEA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0062023	collagen-containing extracellular matrix	-	HDA	23979707 27068509
GO:0062023	collagen-containing extracellular matrix	colocalizes_with	HDA	20551380
GO:0070062	extracellular exosome	-	HDA	19199708

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21197116	Genome-wide association analyses of genetic, phenotypic, and environmental risks in the age-related eye disease study. (2010 Dec 17)	Ryu E	Mol Vis
22247473	Prospective assessment of genetic effects on progression to different stages of age-related macular degeneration using multistate Markov models. (2012 Mar)	Yu Y	Invest Ophthalmol Vis Sci
21541267	Complement factor B polymorphism 32W protects against age-related macular degeneration. (2011 Apr 20)	Hughes AE	Mol Vis
29801032	Association of Single-Nucleotide Polymorphisms in Age-Related Macular Degeneration With Pseudodrusen: Secondary Analysis of Data From the Comparison of AMD Treatments Trials. (2018 May 3)	Lin LY	JAMA Ophthalmol
21402993	Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors. (2011 Mar)	Chen Y	Arch Ophthalmol
27668132	Novel Mechanistic Interplay between Products of Oxidative Stress and Components of the Complement System in AMD Pathogenesis. (2016 Feb)	Du H	Open J Ophthalmol
19187590	Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population. (2008 Dec 20)	Chu J	Chin Med J (Engl)
18164066	Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration. (2008 Jul)	Deangelis MM	Ophthalmology
19796758	Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration. (2009 Dec)	Andreoli MT	Am J Ophthalmol
18162041	Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. (2007 Dec)	Hughes AE	PLoS Med
22273503	Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population. (2012 Mar)	Kim SJ	Exp Eye Res
26218915	Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B. (2015 Jul)	Keenan TD	Invest Ophthalmol Vis Sci
20538655	Polymorphisms in CFH, HTRA1 and CX3CR1 confer risk to exudative age-related macular degeneration in Han Chinese. (2010 Sep)	Yang X	Br J Ophthalmol
28846052	Association of HTRA1 rs11200638 with age-related macular degeneration (AMD) in Brazilian patients. (2018 Jan-Feb)	Lana TP	Ophthalmic Genet
21959373	Risk models for progression to advanced age-related macular degeneration using demographic, environmental, genetic, and ocular factors. (2011 Nov)	Seddon JM	Ophthalmology
22155603	Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration. (2011 Oct)	Morrison MA	Hum Genomics
27239555	Oxidative stress, innate immunity, and age-related macular degeneration. (2016)	Shaw PX	AIMS Mol Sci
22551349	Leucocyte telomere length in age-related macular degeneration. (2013 Aug)	Immonen I	Acta Ophthalmol
18806297	Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration. (2009 Feb)	McKay GJ	Invest Ophthalmol Vis Sci
25277308	FPR1 interacts with CFH, HTRA1 and smoking in exudative age-related macular degeneration and polypoidal choroidal vasculopathy. (2014 Dec)	Liang XY	Eye (Lond)
21558292	CFH, VEGF and HTRA1 promoter genotype may influence the response to intravitreal ranibizumab therapy for neovascular age-related macular degeneration. (2012 Feb)	McKibbin M	Br J Ophthalmol
20456446	LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population. (2010 Oct)	Lee SJ	Clin Exp Ophthalmol
21682878	Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. (2011 Jun 17)	Feehan M	BMC Med Genet
20346514	C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. (2010 Aug)	Seddon JM	Ophthalmology
18718667	The HtrA1 promoter polymorphism, smoking, and age-related macular degeneration in multiple case-control samples. (2008 Nov)	Tuo J	Ophthalmology
25205867	Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice. (2014 Sep 9)	Nakayama M	Invest Ophthalmol Vis Sci
20090206	The molecular genetic basis of age-related macular degeneration: an overview. (2009 Dec)	Katta S	J Genet
21447678	Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)	Yu Y	Invest Ophthalmol Vis Sci
20688737	Joint effect of cigarette smoking and CFH and LOC387715/HTRA1 polymorphisms on polypoidal choroidal vasculopathy. (2010 Dec)	Nakanishi H	Invest Ophthalmol Vis Sci
22487577	Genotype-phenotype associations in neovascular age-related macular degeneration. (2012 Oct)	Hogg RE	Retina
24332379	Predictors of anti-VEGF treatment response in neovascular age-related macular degeneration. (2014 Jan-Feb)	Finger RP	Surv Ophthalmol
20576771	Determination of a gene and environment risk model for age-related macular degeneration. (2010 Oct)	Gibson J	Br J Ophthalmol
26681391	Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study. (2016 Mar)	Finger RP	Ophthalmology
18316707	HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. (2008 Jun)	Tam PO	Invest Ophthalmol Vis Sci
19048105	Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. (2008)	Seitsonen SP	PLoS One
18097986	Review of genetics in age related macular degeneration. (2007 Oct-Dec)	Montezuma SR	Semin Ophthalmol
25655794	Risk Prediction for Progression of Macular Degeneration: 10 Common and Rare Genetic Variants, Demographic, Environmental, and Macular Covariates. (2015 Apr)	Seddon JM	Invest Ophthalmol Vis Sci
20339564	Risk factors for age-related maculopathy. (2009)	Connell PP	J Ophthalmol
23481534	Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. (2013 May)	Reynolds R	Ophthalmology
18541031	The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (2008 Jun 9)	Zhang H	BMC Med Genet
26171855	Analysis of Genetic and Environmental Risk Factors and Their Interactions in Korean Patients with Age-Related Macular Degeneration. (2015)	Woo SJ	PLoS One
19255159	Localization of age-related macular degeneration-associated ARMS2 in cytosol, not mitochondria. (2009 Jul)	Wang G	Invest Ophthalmol Vis Sci
21203342	Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration. (2010 Dec 31)	Yasuma TR	Mol Vis
19169232	Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study. (2009 Dec)	Farwick A	Eye (Lond)
19027484	Age-related macular degeneration. (2008 Nov 22)	Coleman HR	Lancet