Gene: PSAP

5660
GLBA|SAP1
prosaposin
protein-coding
10q22.1
Ensembl:ENSG00000197746 MIM:176801 Vega:OTTHUMG00000018429 UniprotKB:P07602
NG_009301.1
PubMed|SNP Mapped
2   ANCO-SNPs
CD|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.654e-1 (AD)  1.657e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4747204chr10:71839132 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2854992chr10:71826828 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APLP20.96
RAB1B0.958
EIF4H0.957
ADD10.957
DLST0.95
AMFR0.95
GRINA0.949
TSPAN30.948
AAMP0.948
STARD70.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.882
OR4F29-0.847
MTRNR2L6-0.234
OR6C74-0.225
KLRB1-0.212
MTRNR2L9-0.209
FCRL1-0.205
GZMK-0.197
CLEC6A-0.196
MTRNR2L10-0.195

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01966Di-Stearoyl-3-Sn-PhosphatidylethanolamineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PSAP mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of PSAP mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PSAP mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of PSAP mRNA25704631
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of PSAP mRNA17093179
D000082AcetaminophenAcetaminophen affects the expression of PSAP mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PSAP mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PSAP mRNA]17585979
D019386AlendronateAlendronate affects the expression of PSAP mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PSAP mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PSAP mRNA24449571
C015001arsenitearsenite results in increased methylation of PSAP promoter23974009
D001280AtrazineAtrazine results in increased expression of PSAP mRNA26518232
C547126AZM551248AZM551248 results in increased expression of PSAP mRNA22323515
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of PSAP mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PSAP mRNA15034205
D004958EstradiolEstradiol results in decreased expression of PSAP mRNA16202921
C095105bexarotenebexarotene results in increased expression of PSAP mRNA16648578
C006780bisphenol Abisphenol A affects the expression of PSAP mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PSAP mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of PSAP mRNA17553608
D000069286BortezomibBortezomib results in increased expression of PSAP mRNA20977926
C584509C646 compoundC646 compound results in increased expression of PSAP mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PSAP mRNA27339419
D002518CeramidesPSAP gene mutant form results in increased abundance of Ceramides10399097
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PSAP mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of PSAP mRNA26352163
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PSAP mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PSAP mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of PSAP mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of PSAP mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PSAP mRNA20106945
C093628cyproconazolecyproconazole results in increased expression of PSAP mRNA22334560
D003907DexamethasoneDexamethasone results in decreased expression of PSAP mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PSAP mRNA]20032058
D002945CisplatinCisplatin affects the reaction [Piroxicam results in decreased expression of PSAP mRNA]21858171
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of PSAP mRNA17093179
D002117CalcitriolCalcitriol results in increased expression of PSAP mRNA12875902
D004317DoxorubicinDoxorubicin results in decreased expression of PSAP protein18440303
C070609EMD 53998EMD 53998 analog results in decreased expression of PSAP mRNA24977338
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PSAP protein23301498
C109476epoxiconazoleepoxiconazole results in increased expression of PSAP mRNA22334560
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PSAP mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PSAP mRNA15212814|1607927
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PSAP mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of PSAP mRNA23649840
D002112CalcifediolCalcifediol deficiency results in decreased expression of PSAP mRNA17293106
C492448ICG 001ICG 001 results in increased expression of PSAP mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PSAP mRNA25613284
C544151jinfukangjinfukang results in increased expression of PSAP mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of PSAP protein17337753
C410337K 7174K 7174 results in increased expression of PSAP mRNA24086573
D007649KetamineKetamine results in increased expression of PSAP mRNA20080153
C533894LG 100815LG 100815 results in increased expression of PSAP mRNA16951191
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of PSAP mRNA25613284
D008344Maneb[Paraquat co-treated with Maneb] results in decreased expression of PSAP mRNA18386188
D008727MethotrexatePSAP protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PSAP mRNA23458150
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PSAP mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PSAP mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PSAP mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PSAP mRNA"25448806
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PSAP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PSAP mRNA"25554681|2562005
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of PSAP mRNA"16951191
C030110oxaliplatinoxaliplatin results in increased expression of PSAP mRNA17762391
D017239PaclitaxelPaclitaxel results in decreased expression of PSAP mRNA15000894
C016030pantogabpantogab results in increased expression of PSAP mRNA17379144
D010269Paraquat[Paraquat co-treated with Maneb] results in decreased expression of PSAP mRNA18386188
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PSAP mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PSAP mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PSAP protein26879310
D010665PhenylpropanolaminePhenylpropanolamine results in decreased expression of PSAP mRNA16465460
C006253pirinixic acidpirinixic acid results in increased expression of PSAP mRNA18301758|2081375
D010894PiroxicamCisplatin affects the reaction [Piroxicam results in decreased expression of PSAP mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of PSAP mRNA21858171
C045950propiconazolepropiconazole results in increased expression of PSAP mRNA22334560
C010313pseudocumenepseudocumene results in decreased expression of PSAP protein17337753
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PSAP mRNA16079270
D012406RoxarsoneRoxarsone results in increased expression of PSAP protein21652273
D012643SeleniumSelenium results in increased expression of PSAP mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of PSAP protein25895662
D012969Sodium FluorideSodium Fluoride results in decreased expression of PSAP protein28918527
D053260SootSoot results in increased expression of PSAP mRNA26551751
D013629TamoxifenTamoxifen affects the expression of PSAP mRNA17555576
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PSAP mRNA]20032058
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PSAP mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PSAP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PSAP mRNA15034205|1946511
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PSAP mRNA19770486
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PSAP mRNA25613284
D013893ThiramThiram results in increased expression of PSAP mRNA20530235
C009495titanium dioxide[Vitallium analog binds to titanium dioxide] which results in increased expression of PSAP mRNA23825117
C009495titanium dioxidetitanium dioxide affects the expression of PSAP mRNA23557971
D014212TretinoinTretinoin results in increased expression of PSAP mRNA12875902
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PSAP gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PSAP mRNA"26179874
C022884undecaneundecane results in decreased expression of PSAP protein17337753
D014520UrethaneUrethane results in increased expression of PSAP mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PSAP mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PSAP mRNA23179753|2718838
C025643vinclozolinvinclozolin results in increased expression of PSAP mRNA22570695
D014800Vitallium[Vitallium analog binds to titanium dioxide] which results in increased expression of PSAP mRNA23825117
D014800VitalliumVitallium analog results in increased expression of PSAP mRNA23825117
D014810Vitamin EVitamin E results in increased expression of PSAP mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004565beta-galactosidase activity-IDA1454804  
GO:0005515protein binding-IPI16713569  20709014  22431521  24872419  
GO:0005543phospholipid binding-IDA14674747  
GO:0008047enzyme activator activity-TAS2717620  
GO:0008289lipid binding-TAS1454804  
GO:0042803protein homodimerization activity-IDA18462685  
GO:1905573ganglioside GM1 binding-IDA1454804  
GO:1905574ganglioside GM2 binding-IDA1454804  
GO:1905575ganglioside GM3 binding-IDA1454804  
GO:1905576ganglioside GT1b binding-IDA1454804  
GO:1905577ganglioside GP1c binding-IDA1454804  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006687glycosphingolipid metabolic process-TAS1454804  
GO:0006869lipid transport-TAS1454804  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IBA21873635  
GO:0010506regulation of autophagy-TAS22949512  
GO:0019216regulation of lipid metabolic process-IBA21873635  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO:0060736prostate gland growth-IBA21873635  
GO:0060742epithelial cell differentiation involved in prostate gland development-IBA21873635  
GO:0071310cellular response to organic substance-IEA-  
GO:1903206negative regulation of hydrogen peroxide-induced cell death-IEA-  
GO:1905572ganglioside GM1 transport to membrane-IDA1454804  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  20551380  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA1454804  
GO:0005615extracellular space-ISS22261194  
GO:0005764lysosome-IDA22431521  
GO:0005765lysosomal membrane-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0035577azurophil granule membrane-TAS-  
GO:0043202lysosomal lumen-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25664566Neural correlates of impulsive aggressive behavior in subjects with a history of alcohol dependence. (2015 Apr)Kose SBehav Neurosci