Gene: CYP26B1

56603
CYP26A2|P450RAI-2|P450RAI2|RHFCA
cytochrome P450 family 26 subfamily B member 1
protein-coding
2p13.2
Ensembl:ENSG00000003137 MIM:605207 Vega:OTTHUMG00000129756 UniprotKB:Q9NR63
NG_007957.1
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.789e-1 (AD)  4.831e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg17498867chr2:72371552CYP26B18.500e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCLK10.907
HECW10.904
PTPN30.901
PTPRT0.899
GPR1580.898
GREM20.891
PCLO0.888
NELL10.887
RASGRP10.887
STXBP5L0.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.583
YES1-0.565
MBNL3-0.559
COPZ2-0.555
RNF135-0.554
HEY2-0.55
ROM1-0.547
CHST14-0.543
MYL3-0.538
AGTRAP-0.535

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00755TretinoinSmall Molecule302-79-4Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of CYP26B1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CYP26B1 mRNA"22698814|2890350
C0555064-(diethylamino)benzaldehyde4-(diethylamino)benzaldehyde inhibits the reaction [R 115866 results in decreased activity of CYP26B1 protein]17164423
C0194294-hydroxyretinoic acid4-hydroxyretinoic acid affects the expression of CYP26B1 mRNA16054125
C0022024-oxoretinoic acid4-oxoretinoic acid affects the expression of CYP26B1 mRNA16054125
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of CYP26B1 mRNA20932894
D000082AcetaminophenAcetaminophen affects the expression of CYP26B1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of CYP26B1 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of CYP26B1 mRNA19920212
C103303alitretinoinalitretinoin results in increased expression of CYP26B1 mRNA28689802
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CYP26B1 mRNA16483693
D001115ArecolineArecoline results in decreased expression of CYP26B1 mRNA17682004
D001151ArsenicArsenic affects the methylation of CYP26B1 gene25304211
D001151ArsenicArsenic results in increased expression of CYP26B1 mRNA19654921
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CYP26B1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CYP26B1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP26B1 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP26B1 mRNA27195522
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP26B1 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CYP26B1 mRNA19619570
C095105bexarotenebexarotene results in increased expression of CYP26B1 mRNA17849452
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of CYP26B1 mRNA27685785
C006780bisphenol Abisphenol A affects the expression of CYP26B1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of CYP26B1 mRNA25181051
D002104CadmiumCadmium results in decreased expression of CYP26B1 mRNA19556237
D002166CamptothecinCYP26B1 mRNA results in decreased susceptibility to Camptothecin25269479
D002737ChloropreneChloroprene results in decreased expression of CYP26B1 mRNA23125180
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of CYP26B1 mRNA21356183
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CYP26B1 gene20938992
D003033Coal TarCoal Tar results in decreased expression of CYP26B1 mRNA27858113
D003042CocaineCYP26B1 protein results in decreased susceptibility to Cocaine27899881
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of CYP26B1 mRNA21356183
D003300CopperCopper results in decreased expression of CYP26B1 mRNA21356183
D019327Copper SulfateCopper Sulfate results in increased expression of CYP26B1 mRNA19549813
C093628cyproconazolecyproconazole results in increased expression of CYP26B1 mRNA22045034
C014347decitabinedecitabine affects the expression of CYP26B1 mRNA23300844
D003671DEET[fipronil co-treated with DEET] results in increased expression of CYP26B1 mRNA27091632
D002945CisplatinCisplatin affects the expression of CYP26B1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CYP26B1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CYP26B1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CYP26B1 mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of CYP26B1 mRNA25016146
C014476diethyl maleatediethyl maleate results in decreased expression of CYP26B1 mRNA21161181
D002117CalcitriolCalcitriol results in increased expression of CYP26B1 mRNA16002434|2648566
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CYP26B1 mRNA"22485181
D004237DiuronDiuron metabolite results in increased expression of CYP26B1 mRNA24172598
C012301domoic aciddomoic acid results in decreased expression of CYP26B1 mRNA18936300
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP26B1 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of CYP26B1 mRNA17557909
C024565ethylene dichlorideethylene dichloride results in increased expression of CYP26B1 mRNA28189721
C082360fipronil[fipronil co-treated with DEET] results in increased expression of CYP26B1 mRNA27091632
C082360fipronilfipronil results in increased expression of CYP26B1 mRNA27091632
D015725FluconazoleFluconazole results in increased expression of CYP26B1 mRNA19429397
D005473FluoxetineFluoxetine results in decreased expression of CYP26B1 mRNA17033635
C061365flusilazoleflusilazole results in increased expression of CYP26B1 mRNA28263823
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CYP26B1 gene20938992
C069837fullerene C60fullerene C60 results in decreased expression of CYP26B1 mRNA19167457
C039281furanfuran results in decreased methylation of CYP26B1 gene27387713
C039281furanfuran results in increased expression of CYP26B1 mRNA25539665|2738771
C409722hexaconazolehexaconazole results in increased expression of CYP26B1 mRNA22045034
C000625836HFPO4 compoundHFPO4 compound results in increased expression of CYP26B1 mRNA27553808
D017313FenretinideFenretinide results in increased expression of CYP26B1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of CYP26B1 mRNA14592467
D007545IsoproterenolIsoproterenol results in decreased expression of CYP26B1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CYP26B1 mRNA27392435
D007654KetoconazoleKetoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]21906690
D007654KetoconazoleKetoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]14532297
D007654KetoconazoleKetoconazole results in decreased activity of CYP26B114532297
C011890kojic acidkojic acid results in increased expression of CYP26B1 mRNA16595896
C045463leflunomideleflunomide results in decreased expression of CYP26B1 mRNA19751817
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]17185629
D008345ManganeseManganese results in decreased expression of CYP26B1 mRNA26745496
C025340manganese chloridemanganese chloride results in decreased expression of CYP26B1 mRNA26745496
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CYP26B1 gene20938992
D008731MethoxychlorMethoxychlor results in increased expression of CYP26B1 mRNA23303685
D008731MethoxychlorMethoxychlor results in increased methylation of CYP26B1 gene23303685
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CYP26B1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CYP26B1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CYP26B1 mRNA"25620056
C007350nitrofennitrofen results in decreased expression of CYP26B1 mRNA17203325
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CYP26B1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of CYP26B1 mRNA25729387
D010269ParaquatParaquat results in increased expression of CYP26B1 mRNA21371552
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CYP26B1 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP26B1 mRNA28511854
D010634PhenobarbitalPhenobarbital results in increased expression of CYP26B1 mRNA22258563
D010634PhenobarbitalPhenobarbital affects the expression of CYP26B1 mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of CYP26B1 mRNA18158353
D010936Plant ExtractsPlant Extracts inhibits the reaction [quinalphos results in decreased expression of CYP26B1 mRNA]24581381
D011441PropylthiouracilPropylthiouracil results in decreased expression of CYP26B1 mRNA24780913
C012526quercitrinquercitrin results in increased expression of CYP26B1 mRNA25193878
C009145quinalphosPlant Extracts inhibits the reaction [quinalphos results in decreased expression of CYP26B1 mRNA]24581381
C009145quinalphosquinalphos results in decreased expression of CYP26B1 mRNA24581381
C406527R 1158664-(diethylamino)benzaldehyde inhibits the reaction [R 115866 results in decreased activity of CYP26B1 protein]17164423
C406527R 115866R 115866 results in decreased activity of CYP26B1 protein17164423
C406527R 115866[R 115866 results in decreased activity of CYP26B1 protein] which results in increased activity of Tretinoin20606468
C406527R 115866[R 115866 co-treated with Vitamin A] results in increased expression of CYP26B1 mRNA17510468
C406527R 115866[R 115866 results in decreased activity of CYP26B1 protein] which results in increased abundance of Tretinoin17510468
C406527R 115866R 115866 results in increased expression of CYP26B1 mRNA17510468
C450682R116010R116010 promotes the reaction [Isotretinoin results in increased expression of CYP26B1 mRNA]17486130
C450682R116010R116010 promotes the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]17486130
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA19059307
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of CYP26B1 mRNA25905778
D015474IsotretinoinIsotretinoin results in increased expression of CYP26B1 mRNA17486130|1876912
D015474IsotretinoinR116010 promotes the reaction [Isotretinoin results in increased expression of CYP26B1 mRNA]17486130
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CYP26B1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CYP26B1 mRNA23806026
D012999SomanSoman results in increased expression of CYP26B1 mRNA19281266
D053260SootSoot affects the expression of CYP26B1 mRNA26551751
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of CYP26B1 mRNA25905778
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA19059307
D013629TamoxifenTamoxifen results in decreased expression of CYP26B1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP26B1 mRNA16443690
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CYP26B1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP26B1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP26B1 mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP26B1 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP26B1 mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP26B1 mRNA19490992
C009495titanium dioxidetitanium dioxide results in decreased expression of CYP26B1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CYP26B1 mRNA20133372
D014050TolueneToluene affects the expression of CYP26B1 mRNA18653662
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CYP26B1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CYP26B1 mRNA25729387
D014212TretinoinTretinoin affects the expression of CYP26B1 mRNA16054125
D014212TretinoinTretinoin affects the expression of CYP26B1 mRNA17164423
D014212TretinoinTretinoin results in increased expression of CYP26B1 mRNA18230668|2053023
D014212TretinoinCYP26B1 gene SNP results in decreased abundance of Tretinoin29379198
D014212TretinoinCYP26B1 protein affects the degradation of Tretinoin16574820
D014212TretinoinCYP26B1 protein binds to and results in increased metabolism of Tretinoin21906690
D014212TretinoinCYP26B1 protein results in decreased activity of Tretinoin20606468
D014212TretinoinCYP26B1 protein results in increased metabolism of and results in decreased abundance of Tretinoin29379198
D014212TretinoinCYP26B1 protein results in increased metabolism of Tretinoin17486130
D014212TretinoinCYP26B1 results in increased metabolism of Tretinoin14532297
D014212TretinoinKetoconazole inhibits the reaction [CYP26B1 protein results in increased metabolism of Tretinoin]21906690
D014212TretinoinKetoconazole inhibits the reaction [CYP26B1 results in increased metabolism of Tretinoin]14532297
D014212Tretinoin[R 115866 results in decreased activity of CYP26B1 protein] which results in increased activity of Tretinoin20606468
D014212TretinoinR116010 promotes the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]17486130
D014212TretinoinTretinoin results in increased expression of CYP26B1 mRNA17431108|1748613
D014212TretinoinTretinoin results in increased expression of CYP26B1 mRNA16688765
D014212TretinoinCYP26B1 protein results in increased degradation of Tretinoin21138835|2789988
D014212TretinoinLipopolysaccharides inhibits the reaction [Tretinoin results in increased expression of CYP26B1 mRNA]17185629
D014212Tretinoin[R 115866 results in decreased activity of CYP26B1 protein] which results in increased abundance of Tretinoin17510468
D014212TretinoinTretinoin results in increased expression of CYP26B1 mRNA14592467|1718562
D014212TretinoinTretinoin results in increased expression of CYP26B1 mRNA28689802
D014212TretinoinCYP26B1 protein results in increased degradation of Tretinoin17510468
D014212TretinoinCYP26B1 protein results in increased metabolism of and results in decreased activity of Tretinoin16933217
D014212TretinoinCYP26B1 protein results in increased metabolism of Tretinoin21674038
C032910triadimefontriadimefon results in increased expression of CYP26B1 mRNA24962053
D014241TrichloroethyleneTrichloroethylene results in decreased expression of CYP26B1 mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of CYP26B1 mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of CYP26B1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of CYP26B1 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased expression of CYP26B1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of CYP26B1 mRNA24383497|2800136
D014635Valproic AcidValproic Acid affects the expression of CYP26B1 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of CYP26B1 mRNA22045034
C025643vinclozolinvinclozolin results in increased expression of CYP26B1 mRNA20566332
C017963vinyl carbamatevinyl carbamate results in decreased expression of CYP26B1 mRNA17849452
D014801Vitamin A[R 115866 co-treated with Vitamin A] results in increased expression of CYP26B1 mRNA17510468
C574123walrycin Awalrycin A results in increased expression of CYP26B1 mRNA22314385

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001972retinoic acid binding-IDA10823918  
GO:0005506iron ion binding-IEA-  
GO:0008401retinoic acid 4-hydroxylase activity-IDA10823918  
GO:0008401retinoic acid 4-hydroxylase activity-TAS-  
GO:0016491oxidoreductase activity-IBA21873635  
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen-IDA26937021  
GO:0020037heme binding-NAS10823918  
GO ID GO Term Qualifier Evidence PubMed
GO:0001709cell fate determination-ISS-  
GO:0001768establishment of T cell polarity-IEA-  
GO:0006766vitamin metabolic process-TAS-  
GO:0006805xenobiotic metabolic process-IDA26937021  
GO:0006954inflammatory response-IEA-  
GO:0007140male meiotic nuclear division-ISS-  
GO:0007283spermatogenesis-ISS-  
GO:0009954proximal/distal pattern formation-ISS-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0016125sterol metabolic process-IBA21873635  
GO:0030326embryonic limb morphogenesis-ISS-  
GO:0033189response to vitamin A-IEA-  
GO:0034653retinoic acid catabolic process-IDA10823918  
GO:0043587tongue morphogenesis-IEA-  
GO:0045580regulation of T cell differentiation-IEA-  
GO:0048384retinoic acid receptor signaling pathway-IEA-  
GO:0048387negative regulation of retinoic acid receptor signaling pathway-TAS14532297  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IDA10823918  
GO:0060349bone morphogenesis-IMP22019272  
GO:0061436establishment of skin barrier-IEA-  
GO:0070268cornification-IEA-  
GO:0071300cellular response to retinoic acid-IEA-  
GO:2001037positive regulation of tongue muscle cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA22899867  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
KEGG ID KEGG Term
hsa00830Retinol metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211916VitaminsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-5365859RA biosynthesis pathwayTAS
R-HSA-5579015Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27899881Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction. (2016)Zhang YFront Mol Neurosci