Gene: SLC2A9

56606
GLUT9|GLUTX|UAQTL2|URATv1
solute carrier family 2 member 9
protein-coding
4p16.1
Ensembl:ENSG00000109667 MIM:606142 Vega:OTTHUMG00000044263 UniprotKB:Q9NRM0
NG_011540.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.295e-1 (AD)  5.190e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCTD110.671
ITPRIPL20.65
SNAP230.642
HPD0.64
PPP1R180.627
GJA80.625
RGS30.619
HTR3D0.619
TUBB60.614
NFKB10.613

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASIC2-0.312
SMIM18-0.312
AMER3-0.305
SLC6A5-0.304
NRG1-0.304
SLITRK4-0.302
PPEF1-0.298
HENMT1-0.298
BFSP1-0.298
CDH8-0.297

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00678LosartanSmall Molecule114798-26-4ApprovedTransporter
DB01032ProbenecidSmall Molecule57-66-9Approved|InvestigationalTransporter
DB01914D-glucoseSmall Molecule50-99-7ApprovedTransporter
DB08844Uric AcidSmall Molecule69-93-2Experimental|InvestigationalTransporter
DB09341GlucoseSmall Molecule50-99-7ApprovedTransporter
DB09502Fludeoxyglucose F-18Small Molecule63503-12-8Approved|InvestigationalTransporter
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SLC2A9 mRNA"26377693
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of SLC2A9 mRNA"23829299
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC2A9 mRNA]"19467301
D000082AcetaminophenAcetaminophen affects the expression of SLC2A9 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC2A9 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of SLC2A9 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC2A9 mRNA19770486
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]19605544
D000493AllopurinolAllopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]19605544
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of SLC2A9 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of SLC2A9 mRNA21298039
C011659angelicinangelicin results in increased expression of SLC2A9 mRNA22173200
D001151ArsenicArsenic affects the methylation of SLC2A9 gene25304211
C015001arsenitearsenite results in increased methylation of SLC2A9 promoter23974009
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SLC2A9 mRNA27858113
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]18842065
D001553BenzbromaroneBenzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]19587147
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SLC2A9 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of SLC2A9 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SLC2A9 mRNA20064835|2010694
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SLC2A9 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC2A9 mRNA19770486|2261060
D004958EstradiolEstradiol results in decreased expression of SLC2A9 protein21360409
C006780bisphenol Abisphenol A results in increased methylation of SLC2A9 gene28505145
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SLC2A9 mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of SLC2A9 mRNA27858113
D019327Copper SulfateCopper Sulfate results in decreased expression of SLC2A9 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of SLC2A9 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of SLC2A9 mRNA25562108
D002945CisplatinCisplatin results in increased expression of SLC2A9 mRNA18656965
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of SLC2A9 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of SLC2A9 mRNA19467301
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of SLC2A9 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of SLC2A9 mRNA]19850644
D002117CalcitriolCalcitriol results in increased expression of SLC2A9 mRNA27107558
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]"22967667
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]"22967667
D005363FicusinFicusin results in increased expression of SLC2A9 mRNA22173200
D005632FructoseFructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]18842065
D005632FructoseSLC2A9 protein results in increased transport of Fructose17710649
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]19605544
D005632FructoseAllopurinol inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]19605544
D005632FructoseFructose results in increased expression of SLC2A9 mRNA SNP19605544
D005632FructoseFructose results in increased expression of SLC2A9 protein SNP19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]19605544
D005632FructoseQuercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]19605544
D005632FructoseRutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]19605544
D005839GentamicinsGentamicins results in increased expression of SLC2A9 mRNA18656965
D005947GlucoseGlucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]18842065
D005947GlucoseSLC2A9 protein results in increased transport of Glucose17710649
D017313FenretinideFenretinide results in increased expression of SLC2A9 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of SLC2A9 mRNA17183730
C031534imperatorinimperatorin results in decreased expression of SLC2A9 protein22173200
C031534imperatorinimperatorin results in increased expression of SLC2A9 mRNA22173200
C055542isoimperatorinisoimperatorin results in decreased expression of SLC2A9 protein22173200
C055542isoimperatorinisoimperatorin results in increased expression of SLC2A9 mRNA22173200
C410337K 7174K 7174 results in decreased expression of SLC2A9 mRNA24086573
D019808LosartanLosartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]19587147
D008730MethoxsalenMethoxsalen results in decreased expression of SLC2A9 protein22173200
D008730MethoxsalenMethoxsalen results in increased expression of SLC2A9 mRNA22173200
C420606mulberroside Amulberroside A inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22865646
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SLC2A9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SLC2A9 mRNA"25620056
D010578PetroleumPetroleum affects the expression of SLC2A9 mRNA25208076
D010693PhloretinPhloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]19587147
D010936Plant ExtractsPlant Extracts results in increased expression of SLC2A9 mRNA23557933
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]22967667
D010936Plant ExtractsPlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22967667
C058229polydatinpolydatin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22865646
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]"22967667
C489337potassium oxonate"Drugs, Chinese Herbal inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]"22967667
C489337potassium oxonatemulberroside A inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22865646
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]22967667
C489337potassium oxonatePlant Extracts inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22967667
C489337potassium oxonatepolydatin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22865646
C489337potassium oxonatepotassium oxonate results in increased expression of SLC2A9 mRNA21909718|2296766
C489337potassium oxonatepotassium oxonate results in increased expression of SLC2A9 protein21909718|2286564
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]22967667
C489337potassium oxonateProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22967667
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]21909718
C489337potassium oxonateQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]21909718
C489337potassium oxonateresveratrol inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22865646
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]22967667
D011339ProbenecidProbenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22967667
D011441PropylthiouracilPropylthiouracil results in increased expression of SLC2A9 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of SLC2A9 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of SLC2A9 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]21909718
D011794QuercetinQuercetin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]21909718
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]19605544
D011794QuercetinQuercetin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]19605544
C059514resveratrolresveratrol inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]22865646
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]19605544
D012431RutinRutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]19605544
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC2A9 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC2A9 mRNA23221170
C017947sodium arsenitesodium arsenite affects the methylation of SLC2A9 gene28589171
D013739TestosteroneTestosterone results in decreased expression of SLC2A9 mRNA20589576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC2A9 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC2A9 mRNA21215274
C009495titanium dioxidetitanium dioxide results in increased expression of SLC2A9 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC2A9 mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of SLC2A9 mRNA28973697
D014520UrethaneUrethane results in decreased expression of SLC2A9 mRNA28818685
D014527Uric AcidSLC2A9 protein results in increased transport of Uric Acid18989453
D014527Uric AcidBenzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]18842065
D014527Uric AcidFructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]18842065
D014527Uric AcidGlucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]18842065
D014527Uric AcidSLC2A9 gene polymorphism affects the abundance of Uric Acid18327257
D014527Uric AcidSLC2A9 intron SNP affects the abundance of Uric Acid18327256
D014527Uric AcidSLC2A9 protein affects the transport of Uric Acid18327257
D014527Uric AcidSLC2A9 protein alternative form results in increased transport of Uric Acid18842065
D014527Uric AcidSLC2A9 protein results in decreased secretion of Uric Acid22132990
D014527Uric AcidBenzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]19587147
D014527Uric AcidLosartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]19587147
D014527Uric AcidPhloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]19587147
D014527Uric AcidSLC2A9 protein alternative form affects the transport of Uric Acid19587147
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of SLC2A9 mRNA17183730
D014635Valproic AcidValproic Acid results in decreased methylation of SLC2A9 gene29154799
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of SLC2A9 mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005351carbohydrate:proton symporter activity-NAS10860667  
GO:0005355glucose transmembrane transporter activity-IEA-  
GO:0015143urate transmembrane transporter activity-IDA18327257  
GO:0022857transmembrane transporter activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008645hexose transmembrane transport-TAS-  
GO:0015747urate transport-IEA-  
GO:0046415urate metabolic process-IMP18834626  19503597  20053405  
GO:1902600proton transmembrane transport-IEA-  
GO:1904659glucose transmembrane transport-NAS10860667  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0016021integral component of membrane-NAS10860667  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-189200Cellular hexose transportTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-5619047Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23422251Short communication: genetic variations of SLC2A9 in relation to Parkinson's disease. (2013 Feb 19)Gao JTransl Neurodegener
22212408Effects of SLC2A9 variants on uric acid levels in a Korean population. (2013 Jan)Sull JWRheumatol Int