Gene: DIABLO

56616
DFNA64|SMAC
diablo IAP-binding mitochondrial protein
protein-coding
12q24.31
Ensembl:ENSG00000284934 MIM:605219 Vega:OTTHUMG00000157014 UniprotKB:Q9NR28
NG_029459.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg19529732chr12:122712101DIABLO7.200e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRP540.902
PSMD140.901
GTPBP40.9
KHDRBS10.898
TSN0.897
CHMP50.889
SAR1A0.888
STX120.888
GDI20.887
C11orf580.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.692
OR4F29-0.664
MTRNR2L6-0.355
MTRNR2L9-0.333
MTRNR2L10-0.332
MTRNR2L3-0.284
P2RY14-0.278
FMO3-0.274
RSPO1-0.272
C8orf74-0.271

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one affects the localization of DIABLO protein"20833157
C55429110-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one"10-methoxy-2,2-dimethyl-2,6-dihydropyrano(3,2-c)quinolin-5-one promotes the reaction [XIAP protein binds to DIABLO protein]"20833157
C4728291-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole"[Bortezomib co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in decreased localization of DIABLO protein"15070698
C5172321,2-dibromo-4-(1,2-dibromoethyl)cyclohexane"1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane results in increased expression of DIABLO mRNA"24375616
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of DIABLO mRNA"27589474
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane affects the localization of DIABLO protein"12788809
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DIABLO mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of DIABLO mRNA"20702594
C4408502,4,3',5'-tetramethoxystilbene"2,4,3',5'-tetramethoxystilbene results in increased localization of DIABLO protein"20490654
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DIABLO mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of DIABLO mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of DIABLO mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of DIABLO mRNA]28655636
C0801943-hydroxy-4-pentenoic acid3-hydroxy-4-pentenoic acid promotes the reaction [Oxygen deficiency results in increased secretion of DIABLO protein]17671207
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DIABLO mRNA"27188386
C1109625,6-dichlorobenzimidazole"5,6-dichlorobenzimidazole promotes the reaction [TNFSF10 protein affects the localization of DIABLO protein]"15688023
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DIABLO mRNA"27188386
C4833216-bromoindirubin-3'-oxime6-bromoindirubin-3'-oxime promotes the reaction [sorafenib affects the localization of DIABLO protein]17991738
C0548527-hydroxystaurosporine[7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of DIABLO protein15767555
C0548527-hydroxystaurosporineBoc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of DIABLO protein]15767555
D000082AcetaminophenAcetaminophen results in increased expression of DIABLO mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of DIABLO mRNA17562736
D000082AcetaminophenAcetaminophen affects the localization of DIABLO protein17906064|2700250
D000082AcetaminophenAcetaminophen results in increased transport of DIABLO protein28123000
D000082AcetaminophenMetformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]27562556
D000082AcetaminophenMitoTEMPO inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]27002509
D000082Acetaminophen[NQO1 gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of DIABLO protein25224400
D000241AdenosineAdenosine results in increased expression of DIABLO mRNA20063052
D000241AdenosineAdenosine results in increased expression of DIABLO protein20063052
D000241AdenosineDipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]20063052
D000241AdenosineDipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein]20063052
C038491allyl sulfideallyl sulfide results in decreased localization of DIABLO protein17647244
D024502alpha-Tocopherolalpha-Tocopherol affects the localization of DIABLO protein15582575
C077990alvocidibalvocidib affects the localization of DIABLO protein12517783
C077990alvocidib[alvocidib co-treated with Bortezomib] results in increased secretion of DIABLO protein15039284
C077990alvocidib[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of DIABLO protein15634644
C077990alvocidib[Imatinib Mesylate co-treated with alvocidib] results in increased secretion of DIABLO protein12231544
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of DIABLO protein16483693
C540917anthraceno(1,2-c)(1,2,5)selenadiazolo-6,11-dione"anthraceno(1,2-c)(1,2,5)selenadiazolo-6,11-dione affects the localization of DIABLO protein"19146838
C006632arsenic trioxide[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein27430728
D001241AspirinAspirin results in decreased expression of DIABLO protein15976387
D000069461Bendamustine HydrochlorideBendamustine Hydrochloride results in increased localization of DIABLO protein12948851
D000069461Bendamustine HydrochlorideCladribine promotes the reaction [Bendamustine Hydrochloride results in increased localization of DIABLO protein]12948851
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DIABLO mRNA26001963
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Estradiol co-treated with Copper Sulfate] results in increased expression of DIABLO mRNA19945177
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DIABLO mRNA19945177
C110772benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketonebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate affects the localization of DIABLO protein]16054126
D004958Estradiol[Benzo(a)pyrene co-treated with Estradiol co-treated with Copper Sulfate] results in increased expression of DIABLO mRNA19945177
D004958EstradiolEstradiol results in increased expression of DIABLO mRNA19945177
C044887beta-methylcholinebeta-methylcholine affects the expression of DIABLO mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of DIABLO mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of DIABLO mRNA25047013
C006780bisphenol Abisphenol A affects the expression of DIABLO mRNA25181051
C476029Boc-D-FMKBoc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of DIABLO protein]15767555
D000069286Bortezomib[alvocidib co-treated with Bortezomib] results in increased secretion of DIABLO protein15039284
D000069286BortezomibBortezomib affects the localization of DIABLO protein16024631
D000069286Bortezomib"[Bortezomib co-treated with 1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole] results in decreased localization of DIABLO protein"15070698
D000069286Bortezomib[Bortezomib co-treated with Butyrates] affects the localization of DIABLO protein12893773
D000069286Bortezomib[Bortezomib co-treated with TNFSF10 protein] results in increased expression of DIABLO protein12902978
D000069286Bortezomib[Bortezomib co-treated with vorinostat] affects the localization of DIABLO protein12893773
D000069286BortezomibBortezomib inhibits the reaction [BAX mutant form inhibits the reaction [TNFSF10 protein results in increased localization of DIABLO protein]]12902978
D000069286BortezomibBortezomib promotes the reaction [TNFSF10 protein results in increased localization of DIABLO protein]12902978
D000069286BortezomibBortezomib results in increased expression of DIABLO mRNA25913414
D000069286BortezomibBortezomib results in increased expression of DIABLO protein17327374
D000069286BortezomibBortezomib results in increased localization of DIABLO protein14555532
D002084Butylated Hydroxytoluene"Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of DIABLO protein]"14987999
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of DIABLO protein]14987999
D002087Butyrates[Bortezomib co-treated with Butyrates] affects the localization of DIABLO protein12893773
D019256Cadmium ChlorideCadmium Chloride affects the localization of DIABLO protein19887573
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DIABLO mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DIABLO mRNA21297351
C524865carfilzomib[carfilzomib co-treated with vorinostat] affects the localization of DIABLO protein20233973
C086276cerivastatincerivastatin results in increased localization of DIABLO protein15705602
D017338CladribineCladribine promotes the reaction [Bendamustine Hydrochloride results in increased localization of DIABLO protein]12948851
C074702chromium hexavalent ionchromium hexavalent ion affects the localization of DIABLO protein16166740
C074702chromium hexavalent ionTP53 protein affects the reaction [chromium hexavalent ion affects the localization of DIABLO protein]16166740
C012843cinnamic aldehydecinnamic aldehyde affects the localization of DIABLO protein15566391
C012843cinnamic aldehydeVitamin E inhibits the reaction [cinnamic aldehyde affects the localization of DIABLO protein]15566391
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DIABLO mRNA17602206
C463759codonoposidecodonoposide affects the localization of DIABLO protein15863893
D019327Copper Sulfate[Benzo(a)pyrene co-treated with Estradiol co-treated with Copper Sulfate] results in increased expression of DIABLO mRNA19945177
D019327Copper SulfateCopper Sulfate results in increased expression of DIABLO mRNA19945177
C113861corosolic acidcorosolic acid results in decreased expression of DIABLO mRNA28506699
C113861corosolic acidcorosolic acid results in decreased expression of DIABLO protein28506699
D003474Curcumin[arsenic trioxide co-treated with Curcumin] results in increased expression of DIABLO protein27430728
D003474CurcuminCurcumin results in increased expression of DIABLO mRNA23555722
D003474CurcuminCurcumin affects the localization of DIABLO protein17277231
D003474CurcuminDIABLO protein results in increased susceptibility to Curcumin17277231
D016572CyclosporineCyclosporine inhibits the reaction [Paraquat affects the localization of DIABLO protein]25947082
C089595cylindrospermopsincylindrospermopsin results in increased expression of DIABLO mRNA23726867
C093628cyproconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of DIABLO mRNA29038839
C093628cyproconazolecyproconazole results in increased expression of DIABLO mRNA29038839
C004315danthrondanthron results in increased expression of DIABLO protein21126053
D000069439DasatinibDasatinib affects the localization of DIABLO protein20664932
D000069439Dasatinib[NVP-AEW541 co-treated with Dasatinib] affects the localization of DIABLO protein20664932
D003907DexamethasoneDexamethasone affects the localization of DIABLO protein12855565
D003907Dexamethasone[GCS-100 co-treated with Dexamethasone] affects the localization of DIABLO protein16166312
C028009diallyl disulfidediallyl disulfide results in decreased localization of DIABLO protein17647244
D003976DiazinonDiazinon affects the expression of DIABLO mRNA22546817
D003992DibucaineDibucaine inhibits the reaction [Paraquat affects the localization of DIABLO protein]25947082
D002945CisplatinDIABLO protein results in increased susceptibility to Cisplatin18031615|2120476
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA18313992
D004026DieldrinDieldrin affects the expression of DIABLO mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of DIABLO mRNA17602206
D004052Diethylnitrosamine[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of DIABLO mRNA27048571
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of DIABLO mRNA27638505
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Paraquat affects the localization of DIABLO protein]25947082
D004176DipyridamoleDipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]20063052
D004176DipyridamoleDipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein]20063052
C521792DMU-212[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of DIABLO mRNA27048571
D004317DoxorubicinDoxorubicin results in increased expression of DIABLO mRNA17521628
C022999echinocystic acidechinocystic acid analog affects the localization of DIABLO protein15863893
C118739entinostat[fludarabine co-treated with entinostat] results in increased secretion of DIABLO protein15059916
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of DIABLO mRNA24534155
C045651epigallocatechin gallateepigallocatechin gallate analog affects the localization of DIABLO protein16115949
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of DIABLO protein]17936647
C109476epoxiconazole[cyproconazole co-treated with epoxiconazole] results in increased expression of DIABLO mRNA29038839
C456800ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate[alvocidib co-treated with ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate] affects the localization of DIABLO protein15634644
C411675F 12509AF 12509A affects the localization of DIABLO protein16281067
C024352fludarabine[fludarabine co-treated with entinostat] results in increased secretion of DIABLO protein15059916
C024352fludarabine[LAQ824 co-treated with fludarabine] affects the localization of DIABLO protein18852132
D005472FluorouracilDIABLO protein results in increased susceptibility to Fluorouracil18031615
D005472FluorouracilFluorouracil results in increased expression of DIABLO mRNA16557594
D005485FlutamideCBL protein affects the reaction [Flutamide results in increased expression of DIABLO protein]16301331
D005485FlutamideFlutamide inhibits the reaction [CBL protein affects the expression of DIABLO protein]16301331
D005485FlutamideFlutamide results in increased expression of DIABLO protein16301331
D005485FlutamideFlutamide results in decreased expression of DIABLO mRNA24793618
D005485FlutamideFlutamide results in increased expression of DIABLO mRNA24136188
D005492Folic AcidFolic Acid results in increased expression of DIABLO mRNA12969128
D005492Folic AcidFolic Acid results in increased expression of DIABLO protein12969128
C056933fumonisin B1fumonisin B1 results in decreased expression of DIABLO protein25800559
C026226ganglioside, GD3"Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of DIABLO protein]"14987999
C026226ganglioside, GD3"ganglioside, GD3 results in increased secretion of DIABLO protein"14987999
C505531GCS-100[GCS-100 co-treated with Dexamethasone] affects the localization of DIABLO protein16166312
C503536HS-1199HS-1199 affects the localization of DIABLO protein20396553
C479128HS 1200HS 1200 affects the localization of DIABLO protein20396553
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of DIABLO protein21179406
D006861Hydrogen PeroxideButylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of DIABLO protein]14987999
D006861Hydrogen PeroxideHydrogen Peroxide results in increased secretion of DIABLO protein14987999
C492448ICG 001ICG 001 results in increased expression of DIABLO mRNA26191083
D000068877Imatinib Mesylate[Imatinib Mesylate co-treated with alvocidib] results in increased secretion of DIABLO protein12231544
C016517indole-3-carbinolindole-3-carbinol affects the expression of DIABLO mRNA21396975
D007608Kainic AcidKainic Acid results in increased expression of DIABLO mRNA19700661
C477361LAQ824[LAQ824 co-treated with fludarabine] affects the localization of DIABLO protein18852132
C477361LAQ824[LAQ824 co-treated with roscovitine] affects the localization of DIABLO protein16275999
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of DIABLO mRNA21645290
D008687MetforminMetformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]27562556
D008748MethylcholanthreneMethylcholanthrene results in increased expression of DIABLO mRNA18804290
D008777MethyltestosteroneMethyltestosterone results in increased expression of DIABLO mRNA29191790
D008911MinocyclineMinocycline results in decreased secretion of DIABLO protein12930891
D008911MinocyclineMinocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]12930891
D008911MinocyclineMinocycline results in decreased secretion of and results in decreased expression of DIABLO protein14998631
C555916MitoTEMPOMitoTEMPO inhibits the reaction [Acetaminophen affects the localization of DIABLO protein]27002509
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of DIABLO protein24706461
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of DIABLO mRNA18755736
C008548morinmorin results in increased expression of DIABLO mRNA28689916
C051752nefazodonenefazodone results in increased expression of DIABLO mRNA24136188
D009569Nitric OxideNitric Oxide affects the localization of DIABLO protein15126337
C404397NSC 680410NSC 680410 affects the localization of DIABLO protein16481037
C501177NVP-AEW541NVP-AEW541 affects the localization of DIABLO protein20664932
C501177NVP-AEW541[NVP-AEW541 co-treated with Dasatinib] affects the localization of DIABLO protein20664932
C025589ochratoxin Aochratoxin A results in decreased expression of DIABLO mRNA17316727
D010100Oxygen3-hydroxy-4-pentenoic acid promotes the reaction [Oxygen deficiency results in increased secretion of DIABLO protein]17671207
D017239PaclitaxelPaclitaxel affects the localization of DIABLO protein18098270
D017239PaclitaxelPaclitaxel results in increased expression of DIABLO protein17701358
D017239Paclitaxel[resveratrol co-treated with Paclitaxel] affects the localization of DIABLO protein14749477
D017239Paclitaxel[Tretinoin co-treated with Paclitaxel] affects the localization of DIABLO protein18098270
D017239Paclitaxel[Tretinoin co-treated with Paclitaxel] results in increased expression of DIABLO protein17701358
D010269ParaquatCyclosporine inhibits the reaction [Paraquat affects the localization of DIABLO protein]25947082
D010269ParaquatDibucaine inhibits the reaction [Paraquat affects the localization of DIABLO protein]25947082
D010269Paraquatdiphenyleneiodonium inhibits the reaction [Paraquat affects the localization of DIABLO protein]25947082
D010269Paraquatepigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of DIABLO protein]17936647
D010269ParaquatParaquat affects the localization of DIABLO protein22245251|2594708
D010269ParaquatParaquat results in increased expression of DIABLO protein17936647
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of DIABLO mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of DIABLO mRNA28655636
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DIABLO protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of DIABLO mRNA19162173
C058305phenethyl isothiocyanatebenzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [phenethyl isothiocyanate affects the localization of DIABLO protein]16054126
C058305phenethyl isothiocyanateDIABLO protein binds to phenethyl isothiocyanate21838287
C058305phenethyl isothiocyanatephenethyl isothiocyanate affects the localization of DIABLO protein16054126
C058305phenethyl isothiocyanateVitamin E inhibits the reaction [phenethyl isothiocyanate affects the localization of DIABLO protein]16054126
D010634Phenobarbital[DMU-212 co-treated with Diethylnitrosamine co-treated with Phenobarbital] affects the expression of DIABLO mRNA27048571
D045542PQQ CofactorPQQ Cofactor inhibits the reaction [Rotenone results in increased expression of DIABLO protein]26276080
C107773pterostilbenepterostilbene affects the localization of DIABLO protein22572619
C107773pterostilbenepterostilbene results in increased expression of DIABLO protein22450950|2257261
D011794QuercetinQuercetin affects the localization of DIABLO protein23918355
D011794QuercetinQuercetin results in increased expression of DIABLO mRNA20596804
D011794QuercetinQuercetin results in increased localization of DIABLO protein21138867
C059514resveratrolresveratrol affects the localization of DIABLO protein17636462
C059514resveratrol[resveratrol co-treated with Paclitaxel] affects the localization of DIABLO protein14749477
C059514resveratrolresveratrol results in decreased expression of DIABLO protein17872969
C059514resveratrolresveratrol results in increased expression of DIABLO protein15837718
C104586roscovitine[LAQ824 co-treated with roscovitine] affects the localization of DIABLO protein16275999
D012402RotenonePQQ Cofactor inhibits the reaction [Rotenone results in increased expression of DIABLO protein]26276080
D012402RotenoneRotenone results in increased expression of DIABLO protein26276080
D019821SimvastatinDIABLO protein promotes the reaction [Simvastatin results in increased activity of CASP9 protein]20045437
D019821SimvastatinSimvastatin affects the localization of DIABLO protein20045437
D020123Sirolimus[7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of DIABLO protein15767555
D020123SirolimusBoc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of DIABLO protein]15767555
C016104sodium bichromatesodium bichromate results in increased transport of DIABLO protein20298709
C471405sorafenib6-bromoindirubin-3'-oxime promotes the reaction [sorafenib affects the localization of DIABLO protein]17991738
C471405sorafenibGSK3B inhibits the reaction [sorafenib affects the localization of DIABLO protein]17991738
C471405sorafenibsorafenib affects the localization of DIABLO protein16452220|1799173
C471405sorafenib[sorafenib co-treated with TNFSF10 protein] affects the localization of DIABLO protein17909059
D013096SpermineSpermine affects the localization of DIABLO protein16151648
D013311Streptozocin[Streptozocin co-treated with NQO1 protein mutant form] results in increased secretion of DIABLO protein23458895
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DIABLO mRNA20702594
D019284ThapsigarginDIABLO protein affects the susceptibility to Thapsigargin16382148
D019284ThapsigarginThapsigargin affects the localization of DIABLO protein15339911
D019284ThapsigarginThapsigargin results in increased expression of DIABLO mRNA22378314
D013853ThioacetamideThioacetamide results in increased expression of DIABLO mRNA23411599
D014212Tretinoin[Tretinoin co-treated with Paclitaxel] affects the localization of DIABLO protein18098270
D014212Tretinoin[Tretinoin co-treated with Paclitaxel] results in increased expression of DIABLO protein17701358
D014212Tretinoin[Tretinoin co-treated with zoledronic acid] results in decreased expression of DIABLO protein20349282
D014212TretinoinTretinoin results in increased expression of DIABLO protein17701358
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of DIABLO mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of DIABLO mRNA24935251|2627250
D014415TunicamycinTunicamycin results in increased expression of DIABLO mRNA22378314
C000592878UMI-77UMI-77 affects the localization of DIABLO protein24019208
D014635Valproic AcidValproic Acid affects the expression of DIABLO mRNA25979313
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of DIABLO mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of DIABLO mRNA28655636
C025643vinclozolinvinclozolin results in decreased expression of DIABLO mRNA23555832
D014750VincristineVincristine results in decreased expression of DIABLO mRNA23649840
D014810Vitamin EVitamin E inhibits the reaction [cinnamic aldehyde affects the localization of DIABLO protein]15566391
D014810Vitamin EVitamin E inhibits the reaction [phenethyl isothiocyanate affects the localization of DIABLO protein]16054126
C111237vorinostat[Bortezomib co-treated with vorinostat] affects the localization of DIABLO protein12893773
C111237vorinostat[carfilzomib co-treated with vorinostat] affects the localization of DIABLO protein20233973
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of DIABLO mRNA18313992
C088658zoledronic acid[Tretinoin co-treated with zoledronic acid] results in decreased expression of DIABLO protein20349282

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10929712  11604410  11801603  12559088  15200957  15628841  
16282325  16729033  19153467  21185211  21536684  22465666  
23251006  25416956  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-TAS10929712  
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process-TAS18309324  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-TAS10950947  
GO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress-IBA21873635  
GO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c-IBA21873635  
GO:0008635activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c-TAS10929711  
GO:0043065positive regulation of apoptotic process-TAS18309324  
GO:0051402neuron apoptotic process-IBA21873635  
GO:0097193intrinsic apoptotic signaling pathway-TAS18309324  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005758mitochondrial intermembrane space-TAS18309324  
GO:0005829cytosol-TAS-  
GO:0009898cytoplasmic side of plasma membrane-ISS-  
GO:0035631CD40 receptor complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-109581ApoptosisIEA
R-HSA-109606Intrinsic Pathway for ApoptosisTAS
R-HSA-109606Intrinsic Pathway for ApoptosisIEA
R-HSA-111457Release of apoptotic factors from the mitochondriaTAS
R-HSA-111463SMAC binds to IAPs IEA
R-HSA-111463SMAC binds to IAPs TAS
R-HSA-111464SMAC-mediated dissociation of IAP:caspase complexes IEA
R-HSA-111464SMAC-mediated dissociation of IAP:caspase complexes TAS
R-HSA-111469SMAC-mediated apoptotic responseIEA
R-HSA-111469SMAC-mediated apoptotic responseTAS
R-HSA-111471Apoptotic factor-mediated responseIEA
R-HSA-111471Apoptotic factor-mediated responseTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-5357801Programmed Cell DeathIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25421516Markers of apoptosis induction and proliferation in the orbitofrontal cortex in alcohol dependence. (2014 Nov)Whittom AAlcohol Clin Exp Res
21944139Effect of smoking status on seminal parameters and apoptotic markers in infertile men. (2011 Nov)Tawadrous GAJ Urol